ANTI-INFLAMMATORY AND ANTIOXIDANT POTENTIAL OF ZANTHOXYLUM ALATUM ROXB STEM BARK.

Main Article Content

Nishant Kumar
Pooja Puri
Dr. Prince Ahad Mir

Keywords

Zanthoxylum alatum, anti-inflammatory, antioxidant, Carrageenan

Abstract

In humans, reactive oxygen species induce inflammation through oxidative stress. Persistent inflammation generates a large number of free radicals, which eventually create additional inflammation. This never-ending vicious loop can harm multiple components in the human body. In this study, we explored the anti-inflammatory and antioxidant potency of a locally available plant Zanthoxylum alatum utilizing both in vivo and in vitro models. Carrageenan induced paw edema and cotton pellet granuloma model were used to assess the anti-inflammatory potency of the extracts while as DPPH quenching and reducing power estimation were used to assess the antioxidant potency of the drug. Both aqueous and methanolic extracts of Zanthoxylum alatum stem bark showed dose dependent anti-inflammatory and antioxidant potency. Aqueous extract was further fractioned using different organic solvents which also revealed good anti-inflammatory and antioxidant potency. The current data revealed the antioxidant and anti-inflammatory potency of Zanthoxylum alatum. However, more research is needed in order to isolated and identify the active principle in order to support the existing findings.

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References

Petrovska, B.B., Historical review of medicinal plants’ usage. Pharmacognosy reviews, 2012. 6(11): p. 1.
2. Suroowan, S., et al., Ethnoveterinary health management practices using medicinal plants in South Asia–a review. Veterinary research communications, 2017. 41: p. 147-168.
3. Newman, D.J., Modern traditional Chinese medicine: identifying, defining and usage of TCM components. Advances in pharmacology, 2020. 87: p. 113-158.
4. Sani, I., A. Abdulhamid, and F. Bello, Eucalyptus camaldulensis: Phytochemical composition of ethanolic and aqueous extracts of the leaves, stem-bark, root, fruits and seeds. Journal of scientific and innovative Research, 2014. 3(5): p. 523-526.
5. Roy, R.N., et al., Plant nutrition for food security. A guide for integrated nutrient management. FAO Fertilizer and Plant Nutrition Bulletin, 2006. 16(368).
6. Ekor, M., The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. Frontiers in pharmacology, 2014. 4: p. 177.
7. Anand, U., et al., A comprehensive review on medicinal plants as antimicrobial therapeutics: potential avenues of biocompatible drug discovery. Metabolites, 2019. 9(11): p. 258.
8. Akhtar, N., M. Ali, and M. Sarwar Alam, Chemical constituents from the seeds of Zanthoxylum alatum. Journal of Asian natural products research, 2009. 11(1): p. 91-95.
9. Patiño, L.O.J., R.J.A. Prieto, and S.L.E. Cuca, Zanthoxylum genus as potential source of bioactive compounds. Bioactive compounds in phytomedicine, 2012. 10: p. 184-218.
10. Sati, V., Role of Off-Season Vegetables in the Sustainable Livelihood of Hill People: A Case in the Pindar Basin, Uttarakhand Himalaya. HIMALAYAN ECOLOGY, 2007. 15(1&2): p. 35.
11. Kumar, N., et al., Pharmacognostical Standardization, Phytochemical Characteristics of Stem-bark of Zanthoxylum alatum Roxb. Pharmacognosy Research, 2022. 14(3).
12. Botham, P.A., Acute systemic toxicity—prospects for tiered testing strategies. Toxicology in vitro, 2004. 18(2): p. 227-230.
13. Morris, C.J., Carrageenan-induced paw edema in the rat and mouse. Inflammation protocols, 2003: p. 115-121.
14. Sadeghi, H., et al., Further studies on anti-inflammatory activity of maprotiline in carrageenan-induced paw edema in rat. International immunopharmacology, 2013. 15(3): p. 505-510.
15. Winter, C.A. and C.C. Porter, Effect of alterations in side chain upon anti-inflammatory and liver glycogen activities of hydrocortisone esters. Journal of the American Pharmaceutical Association (Scientific ed.), 1957. 46(9): p. 515-519.
16. Lalitha, K. and M. Sethuraman, Anti-inflammatory activity of roots of Ecbolium viride (Forsk) Merrill. Journal of ethnopharmacology, 2010. 128(1): p. 248-250.
17. Kumar, S.S., et al., Evaluation of Anti–Inflammatory Activity of Eclipta alba in rats. Ancient Science of Life, 2005. 24(3): p. 112.
18. Braca, A., et al., Antioxidant principles from bauhinia t arapotensis. Journal of natural products, 2001. 64(7): p. 892-895.
19. Mir, P.A., et al., In-vitro Antioxidant and Anti-inflammatory Potential of Ficus infectoria Fruits. Pharmacognosy Research, 2022. 14(2).
20. Mir, P., et al., Evaluation of antioxidant and anti-inflammatory activity of methanolic and aqueous extract of Arisaema propinquum Schott rhizomes. Journal of Biomedical and Pharmaceuticals Sciences, 2019. 2: p. 120.
21. Oyaizu, M., Studies on products of browning reaction antioxidative activities of products of browning reaction prepared from glucosamine. The Japanese journal of nutrition and dietetics, 1986. 44(6): p. 307-315.
22. Tepe, B., et al., Antimicrobial and antioxidant activities of the essential oil and various extracts of Salvia tomentosa Miller (Lamiaceae). Food chemistry, 2005. 90(3): p. 333-340.