An Evaluation of Drug Prescription Pattern among Outpatients in a Tertiary Care Teaching Hospital in Gujarat

Main Article Content

Kinjal Modiya
Dharna Patel
Kiran Panchal
Pavan Panchal
Apexa Shukla

Keywords

Prescription audit, Prescription pattern, Rational drug use, WHO prescribing indicators, Essential Medicines List, tandard Treatment Guidelines

Abstract

Background: Assessing prescription practices is a crucial tactic for encouraging sensible medication usage and raising the standard of medical care. The World Health Organization's (WHO) core prescribing indicators form the basis for prescription audits, which offer an impartial method of evaluating drug use and pinpointing areas in need of improvement. Using WHO prescribing indicators, this study assessed outpatient prescribing patterns in a Gujarati tertiary care teaching hospital.
Materials and Methods: Over a period over a year, a cross-sectional observational study was carried out at GMERS Medical College in Himmatnagar. Written informed consent was obtained before newly registered outpatients from different clinical departments were enrolled. The completeness, readability, conformity with Standard Treatment Guidelines (STGs), adherence to WHO core prescription indicators, and prescribing from the National List of Essential Medicines (NLEM) were all evaluated. Descriptive statistics were used to analyze the data.
Results: A total of 1,639 medicines from 476 outpatient prescriptions were assessed. 94.2% of prescriptions had multiple medications, and the average number of medications prescribed per prescription was 3.3. Antimicrobials were prescribed in 36.3% of encounters, while vitamins and iron supplements were included in 36.0%. Fixed-dose combinations were present in 19.3% of prescriptions. Major deficiencies were identified in prescription documentation, with omission of patient instructions (97.8%), follow-up advice (92.4%), diagnosis (65.0%), and drug dose (58.8%) being the most frequent.
Conclusion: Although prescribing practices demonstrated satisfactory adherence to STGs and appropriate documentation of dosage form, frequency, and route of administration, important deficiencies in prescription completeness and a high prevalence of polypharmacy were observed. Regular prescription audits, continuous prescriber education, and implementation of standardized or electronic prescribing systems may improve prescription quality, promote rational medicine use, and enhance patient safety.

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References

1. World Health Organization. Promoting rational use of medicines: core components. WHO Policy Perspectives on Medicines. Geneva: World Health Organization; 2002.
2. Ansari M, Neupane D. Study on the determination of errors in prescription writing: a semi-electronic perspective. Kathmandu Univ Med J (KUMJ). 2009;7(27):238-41.
3. Garg M, Vishwakarma P, Sharma M, Nehra R, Saxena KK. The impact of irrational prescribing practices: a wake-up call. J Pharmacol Pharmacother. 2014;5:245-7.
4. Joshi R, Medhi B, Prakash A, Chandy S, Ranjalkar J, Bright HR, et al. Assessment of prescribing pattern of drugs and completeness of prescriptions as per the World Health Organization prescribing indicators in various Indian tertiary care centers: A multicentric study by Rational Use of Medicines Centers-Indian Council of Medical Research network under National Virtual Centre Clinical Pharmacology activity. Indian J Pharmacol. 2022;54(5):321-8.
5. World Health Organization. How to investigate drug use in health facilities: selected drug use indicators. Geneva: World Health Organization; 1993. (accessed on 30 Jun 2025)
6. World Health Organization. Introduction to drug utilization research. Geneva: World Health Organization; 2003. (accessed on 30 Jun 2025)
7. Meenakshi R, Selvaraj N, Anandabaskar N, Dhamodharan A, Badrinath AK, Rajamohammad MA. Prescription audit of a teaching hospital in South India using World Health Organization core prescribing indicators: A cross-sectional study. Perspect Clin Res. 2022;13(3):132-136.
8. Idris SA, Hussien TMA, Al-Shammari FF, Nagi HA, Bashir AI, Elhussein GEMO, et al. An evaluation of drug prescribing patterns and prescription completeness. Healthcare. 2024;12:2221.
9. Dubey L, Sankdia R, Marko S, Gupta P. A cross-sectional study to evaluate the drug prescription pattern of outpatient department patients in a tertiary care teaching hospital. National Journal of Physiology, Pharmacy and Pharmacology. 2022;12(3):381–385.
10. Narayanasamy K, Reddy J, et al. Assessment of prescribing pattern and completeness of prescriptions as per WHO indicators in Indian tertiary care centers. Indian Journal of Pharmacology. 2022;54(6):406–412.
11. Batta A, Ahmed M, et al. Prescription audit of a teaching hospital in South India using WHO core prescribing indicators. Perspectives in Clinical Research. 2021;12(4):180–185.
12. Navadia KP, Patel CR, Patel JM, Pandya SK. Evaluation of medication errors by prescription audit at a tertiary care teaching hospital. Journal of Pharmacology and Pharmacotherapeutics. 2024;14(4):275–284.
13. Verma N, Vinayagam S, Mittal N, Mittal R, Bansal N. Prescription audit in outpatient pharmacy of a tertiary care referral hospital in Haryana using WHO/INRUD core prescribing indicators. Pharmacy. 2025;13:48.
14. World Health Organization. Guide to Good Prescribing. Geneva: World Health Organization; 2020.
15. Shrestha R, Prajapati S. Assessment of prescription pattern and prescription error in outpatient department at a tertiary care district hospital, Central Nepal. Journal of Pharmaceutical Policy and Practice. 2019;12:16.
16. World Health Organization. Global Antibiotic Resistance Surveillance Report. Geneva: World Health Organization; 2025.
17. Jarupala R, et al. Trends in prescribing patterns of vitamins and minerals in clinical practice: A multicenter observational analysis. Journal of Applied Pharmaceutical Science. 2025;15(7):220–234.
18. Anila AB, Ancy PS, Sreelekshmi BS, Mahesh NM, Vishwanath BA. A study on prescription pattern of multivitamins in type 2 diabetes mellitus in a tertiary care hospital. Journal of Drug Delivery and Therapeutics. 2020;10:91–97.
19. Sultana A, Rai R, Shukla M, Rastogi P, Choudhary S, Sharma S. Cost effectiveness of micronutrient supplementation in India: A scoping review. Journal of Food and Nutrition Sciences. 2025;13(5):246–256.
20. Sharma M, Payal N, Devi LS, et al. Study on prescription audit from a rural tertiary care hospital in North India. Journal of Pure and Applied Microbiology. 2021;15(4):1931–1939.
21. Jhanwar A. Prescription auditing using WHO drug prescribing indicators in a tertiary care hospital. National Journal of Physiology, Pharmacy and Pharmacology. 2022;12(9):1480–1484.
22. Patel P, Bhora M, Vishwe A, et al. Prescription audit to evaluate the pattern and errors in a tertiary care hospital. International Journal of Basic and Clinical Pharmacology. 2019;8(12):2650–2654.
23. Gupta N, Agrawal P, Datta S, Verma SK, Suman A. Prescription audit using WHO core prescribing indicators in a tertiary care hospital in North India. Muzaffarnagar Medical College Journal. 2024;12(2):45–50.
24. Singh S, et al. A prescription audit utilizing the World Health Organization recommended key medication use indicators at a tertiary care hospital, India. GAIMS Journal of Medical Sciences. 2025;5(2):116–122.
25. Murthy R, et al. Assessing the compliance of prescription writing practices in a tertiary care private hospital in Kolkata, India. International Journal of Life-Based Pharmaceutical Research. 2023;12(4):446–452.
26. Ralte L, Saxena DC, Kumar P. Study to conduct prescription audit as per objective elements of NABH in medical and surgical wards of a tertiary care teaching hospital. Journal of Drug Delivery and Therapeutics. 2025;15(4):35–41.
27. Mulkalwar S, et al. Prescription audit for WHO prescribing indicators and errors: A study in India. Medical Journal of DY Patil Vidyapeeth. 2024;17.
28. Pal P, Banerjee P, Panja B, et al. Prescription audit of a teaching hospital in Eastern India using a step-by-step methodology. International Journal of Pharmaceutical and Clinical Research. 2024;16(8):1310–1316.
29. Sunny D, Roy K, Benny SS, Chamakalayil DM, Naik JG, Gauthaman K. Prescription audit in an outpatient pharmacy of a tertiary care teaching hospital. Journal of Young Pharmacists. 2019;11(4):417–420.
30. Halder S, Gangopadhyay T, Mondal S, Das AK. Prescription audit from the outpatient department of a rural hospital in West Bengal: A cross-sectional study. Asian Journal of Pharmaceutical and Clinical Research. 2022;15(12):126–129.