Prolidase Specificity as a diagnostic marker for breast cancer

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Sara Tariq Husseen Al-Bayate
Rafah Razooq Hameed Al-Samarrai
Ahmed Zuhair Abdullhameed Alsammarraie
Ali Abbas Ali


Prolidase, Glutathione, Catalase, ceruloplasmin, Malondialdehyde


The study was carried out to evaluate the activity of prolidase-PD (as a diagnostic marker) and some antioxidant parameters in sera of patients with breast cancer. Ninety serum samples were collected from women(60 samples from women with breast cancer-BC and 30 samples from healthy women as a control group) with ages ranging between 30-71 years. The samples were divided into three groups:
Control group C, First group G1 for the newly diagnosed cases with BC, and Second group-G2 for breast cancer after undergoing chemotherapy. The study includes the determination activity of serum enzymes ( PD and catalase-CAT) and the concentration of glutathione-GSH, ceruloplasmin-Crp, and Malondialdehyde-MDA. The results of the present study indicate that the activity of PD, CAT, Crp, and also GSH and MDA significantly elevated (P≤0.05) in the sera of the patients' group(G1 and G2) as compared with the control group. Otherwise, the sensitivity rate for PD,MDA and Crp were 88.89%, 100% and 89.86% respectively in the group newly diagnosed with BC. While in the group after treatment the higher sensitivity rate were shown to MDA with 100% as an indicator for the treatment response and outstanding value for MDA (AUC=1.0) in the patients' groups Vs control. From all the results we can conclude that the high level of prolidase activity was associated with an increased risk of breast cancer, especially with high oxidative stress.

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