ROLE OF SERUM VITAMIN D DEFICIENCY IN ESSENTIAL HYPERTENSION AND ITS CORRELATION WITH SEVERITY OF BLOOD PRESSURE
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Keywords
Vitamin D, Essential Hypertension, Blood Pressure, RAAS, Cardiovascular Risk
Abstract
Background: Essential hypertension is a major global health concern and a leading contributor to cardiovascular morbidity and mortality. Recent evidence suggests that Vitamin D deficiency may play a role in the pathogenesis and progression of hypertension through modulation of the renin–angiotensin–aldosterone system (RAAS), endothelial dysfunction, and vascular inflammation.
Aim: To evaluate serum Vitamin D levels in patients with essential hypertension and to assess its correlation with the severity of blood pressure.
Materials and Methods: A cross-sectional observational study was conducted on 115 patients diagnosed with essential hypertension at a tertiary care center. Serum Vitamin D levels were measured and categorized into deficient, insufficient, and sufficient groups. Blood pressure was recorded and classified into Stage 1 and Stage 2 hypertension. Statistical analysis included correlation and association tests.
Results: Vitamin D deficiency was observed in 66.1% of patients. A significant inverse correlation was found between Vitamin D levels and systolic as well as diastolic blood pressure (p < 0.001). Patients with deficiency had significantly higher blood pressure and were more likely to have Stage 2 hypertension.
Conclusion: Vitamin D deficiency is highly prevalent among hypertensive patients and is significantly associated with increased severity of hypertension, suggesting a potential role in disease progression.
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Dr. Sagar Kumar
Assistant Professor Department of Pharmacology, Netaji Subhas Medical College and Hospital, Adityapur, Jharkhand, India.
Dr. Saurabh Singh
Associate Professor ( General Surgery ), MBBS DNB FIAGES Mch( Burns and Plastic Surgery), Rama Medical College Hospital and Research Centre ,Mandhana
