ASSOCIATION OF SYMPATHOVAGAL IMBALANCE WITH MYOCARDIAL WORK STRESS AND ATHEROGENIC INDEX IN PREHYPERTENSION
Main Article Content
Keywords
Prehypertension, Heart rate variability, sympathovagal imbalance, cardiac autonomic modulation, rate-pressure product, myocardial work stress, atherogenic index.
Abstract
Background: Prehypertension is an early high blood pressure phenotype associated with cardiovascular risk; however, the relationship between cardiac autonomic derangements, atherogenic index, and myocardial work stress remains unclear in younger adults. Therefore, in this study, we evaluated the association between HRV-derived cardiac autonomic modulation and the atherogenic index of plasma and rate pressure product in individuals with prehypertension.
Methods: This cross-sectional study was conducted on apparently healthy adults aged between 18-30 years, comprising 44 prehypertensive individuals and 44 normotensive individuals as controls. Anthropometric variables, resting cardiac parameters, heart rate variability, rate pressure product, fasting lipid profile, and atherogenic index of plasma were assessed. Between-group comparisons and correlation analyses were performed using appropriate statistical tests.
Results: Higher body weight, body mass index, heart rate, blood pressure, and rate pressure product were observed in prehypertensive individuals. In comparison to normotensive controls, prehypertensive individuals had higher LFnu and LF/HF ratio, and lower total power, SDNN, RMSSD, HF power, and HFnu. The lipid profile showed lower HDL cholesterol and higher total cholesterol, triglycerides, LDL cholesterol, VLDL cholesterol, and atherogenic index of plasma. Furthermore, the LF/HF ratio was positively correlated with the rate pressure product and atherogenic index of plasma and negatively correlated with HDL cholesterol.
Conclusion: Young adults with prehypertension demonstrate altered cardiac autonomic modulation associated with increased myocardial work stress and atherogenic lipid risk, supporting the need for early cardiovascular risk assessment.
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Supriya K
MBBS student, Sri Venkateswara Medical College, Tirupati, Chittor (Dist.), Andhra Pradesh, India.
Bandi Hari Krishna
Assistant Professor of Physiology, Sri Venkateswara Medical College, Tirupati, Chittoor (Dist.), Andhra Pradesh, India.
Madhusudhana Pulaganti
Research Scientist, Multidisciplinary Research Unit, Sri Venkateswara Medical College, Tirupati, Chittoor (Dist.), Andhra Pradesh, India.
Ananatha Soma Kireeti
Nodal Officer, Multidisciplinary Research Unit , and Professor of Pediatrics, Sri Venkateswara Medical College, Tirupati, Chittoor (Dist.), Andhra Pradesh, India.
