A STUDY OF UROPATHOGENS, DRUG RESISTANCE PROFILES, AND RISK FACTORS CONTRIBUTING TO URINARY TRACT INFECTIONS AMONG DIABETIC PATIENTS IN A TERTIARY CARE CENTRE, KANPUR
Main Article Content
Keywords
.
Abstract
Background:Urinary tract infections (UTIs) are common among diabetic patients due to impaired immunity, poor glycemic control, and associated complications. These infections often lead to serious outcomes if not diagnosed and treated early.
Aim:To study the bacteriological spectrum, antimicrobial resistance patterns, and associated risk factors of UTIs in diabetic patients attending a tertiary care hospital in Kanpur.
Materials and Methods:This prospective observational study was conducted from January to December 2020. A total of 50 urine samples from diabetic patients were collected and processed using standard microbiological techniques. Identification of isolates and antibiotic susceptibility testing were performed according to CLSI guidelines.
Results:Out of 50 samples, 8 (16%) were culture-positive for UTI. The majority of patients were in the 46–60 years age group (56%). Gram-negative bacilli were predominant (75%), with Escherichia coli (50%) as the most common isolate, followed by Klebsiella species. Gram-positive cocci accounted for 25% of isolates, including Staphylococcus aureus and Staphylococcus lugdunensis. Most Gram-negative isolates showed high sensitivity to Amikacin, Gentamycin, Carbapenems, and Tigecycline, while Gram-positive isolates were highly sensitive to Linezolid, Vancomycin, and Teicoplanin.
Conclusion:UTIs are fairly prevalent among diabetic patients, with E. coli being the predominant pathogen. The presence of antimicrobial resistance highlights the need for regular surveillance and appropriate antibiotic therapy. Early diagnosis and proper management are essential to reduce complications in diabetic individuals.
References
2. Sridhar C, Anjana S, Mathew J. Acute infections. Text Book of Diabetes Mellitus, Chap-34, Ahuja MMS., Tripathy BB., Sam Moses GP., Chandalia HB., Das AK., Rao PV. (ed), RSSDI. Hyderabad, India, 2002; 471–8.
3. Hansen RO. Bacteriuria in diabetic and non-diabetic out-patients. Acta Med Scand. w1964; 176:721–30. doi:10.1111/j.0954-6820. 1964.tb00680. x.
4. Ronald A, Ludwig E. Urinary tract infections in adults with diabetes. Int J Antimicrob Agents. 2001 Apr;17(4):287–92. doi:10.1016/S0924-8579(00)00356-3.
5. World Health Organization. Diabetes country profiles 2016: Malaysia. Geneva: World Health Organization; 2016.
6. Foxman, B.et al. “Epidemiology of urinary tract infections: Transmission and risk factors, incidence, and costs” Infectious Disease Clinical jounal of North America.,2003; 17(2):227-241
7. Nicolle,L. E. et al., “Clinic of Infectious Disease” International journal of North America, 2005;40:64.
8. Smith J, Brown R. Pathophysiology of urinary tract infections. In: Johnson L, editor. Infectious Diseases Illustrated. 2nd ed. New York: Medical Press; 2018. p. 45–7.
9. Gupta K, Hooton TM, Naber KG, et al. International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: A 2010 Microbiology and Infectious Diseases. Clin Infect Dis. 2011 Mar;52(5):e103–20.
10. The Swedish Reference Group for Antibiotics. Imipenem.clinical infection deseas; 2012;89:76-78.
11. W.w.cTopley, sir grahm Wilson, F. E. G. Cox , Derek Wakelin , Stephen Gillespie, Dickson D. Despommier. Topley and Wilson′s Microbiology and Microbial Infections. 10thedition.UK : Hodder frnald 2005.
12. Swedish Reference Group for Antibiotics. Meropenem.clinical infection deseas.2012;89:78-79.
Article Sidebar
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Ms. Archana Yadav
Assistant Professor, Ph.D. Scholar,) Department of MLT, SCPM College of Allied and Healthcare, Gonda.
Ms. Sapna
Assistant Professor Department of MLT, SCPM College of Allied and Healthcare, Gonda
Mr. Amit Kumar
Head DMLT, Department of MLT, Meenu Institute of Nursing and Allied Health Sciences, Hardoi.
