INTEGRATING AYURGENOMICS WITH POLYCYSTIC OVARY SYNDROME: A SCOPING REVIEW OF METABOLIC PHENOTYPES (PRAKRITI) AND PERSONALIZED MANAGEMENT IN STREE ROGA
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Keywords
PCOS, Ayurgenomics, Prakriti, Artava Kshaya, Stree Roga, Personalized Medicine, Metabolic Phenotypes, Tridosha, Shodhana, Genomics.
Abstract
Polycystic Ovary Syndrome (PCOS) is a complex, multi-systemic endocrine and metabolic disorder affecting women of reproductive age, characterized by clinical or biochemical hyperandrogenism, ovulatory dysfunction, and polycystic ovarian morphology. Despite significant advancements in modern endocrinology, the management of PCOS remains largely symptomatic, often failing to address the profound inter-individual variability in metabolic profiles and therapeutic responses. This research paper explores the integration of "Ayurgenomics"—an innovative trans-disciplinary field merging the ancient Ayurvedic science of Prakriti (individual constitution) with modern genomic and "omics" technologies—to provide a personalized framework for the management of PCOS within the domain of Stree Roga (Ayurvedic Gynecology).
Through a comprehensive scoping review adhering to PRISMA-ScR guidelines, this study identifies the molecular basis of the three primary Prakriti types (Vata, Pitta, and Kapha) and correlates them with the four modern PCOS phenotypes (Phenotypes A, B, C, and D). Evidence indicates that Kapha-dominant individuals exhibit a genetic predisposition toward obesity and metabolic syndrome, often involving polymorphisms in the FTO and CYP2C19 genes, whereas Pitta-dominant types demonstrate heightened inflammatory responses and specific metabolic efficiencies. The paper elucidates the Ayurvedic pathophysiology of PCOS, primarily through the lens of Artava Kshaya, Pushpagni Jataharini, and Sroto-avarodha, emphasizing the disruption of the HPO axis as a manifestation of Vata-Kapha imbalance.[i]
The review synthesizes personalized management strategies, contrasting conventional pharmacological interventions like Metformin with Ayurvedic Shodhana (purificatory) protocols such as Virechana and Basti, and Shamana (palliative) herbal formulations. By mapping the "genotype-phenotype" nexus, this study provides a scientific rationale for tailored interventions in Stree Roga, suggesting that Ayurgenomics can transform PCOS management from a reactive symptom-based model to a predictive and personalized preventive paradigm.
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Dr. Hemant Kuma
Assistant Professor, PG Department of Stri Roga evam Prasuti Tantra, Post Graduate Institute of Ayurved, Dr S R Rajasthan Ayurved University Jodhpur
Dr. Ankita Chouhan
PG Scholar PG Department of Stri Roga evam Prasuti Tantra, Post Graduate Institute of Ayurved, Dr S R Rajasthan Ayurved University Jodhpur.
Dr.Varsha
Assistant Professor, Department of Stri Roga evam Prasuti Tantra, Shri Bhanwar Lal Dugar Ayurved Vishva Bharti, Sardarsharhar, Churu, Rajasthan.
