COMPARATIVE STUDY OF HYDROCORTISONE IN-SITU GEL AND BUCCAL MUCOADHESIVE FILM FOR EFFECTIVE MANAGEMENT OF APHTHOUS ULCERS
Main Article Content
Keywords
In situ, Film, Methylcellulose, Gellation temperature & gellation time.
Abstract
The in-situ gels and film were developed by using methylcellulose, based on the concept of temperature dependant gelling system. The sol-to-gel transformation occurred during the reduction of temperature. The in-situ gels were evaluated for gelling capacity, drug content, viscosity & in-vitro release were as in the film it evaluated for tensile strength, folding endurance, thickness etc. The experimental part shows that viscosity of the sol was increased by increasing the concentration of polymer. All the results were found to be satisfactory, when compared between the in-situ gels and films. The has shown the best formulation because of their therapeutic efficacy and provided sustained release of the drug over a period of time. These results demonstrate that the developed system is an alternative to conventional drug delivery system, patient compliance, industrially oriented and economical.
References
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12. Gupta H, Sharma A. Ion- activated bioadhesive in-situ gel of clindamycin for vaginal application. Int j Drug Delivery 2009;(1):32-40.
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32. Barrons R W. Treatment strategies for recurrent oral aphthous ulcers. Am J Health Syst pharm 2001;58(1):41-50 .
33. Boras v v, N W Savage. Recurrent aphthous ulcerative disease: Presentation and management. AVS Dental J 2007;52(1):10-15.
34. Gibson N, Ferguson J W. Steroid cover for dental patients on long-term steroid indication: proposed clinical guidelines based upon a critical review of the literature. Brit Dent J 197(11):681-685.
35. Grover N K, Babu R, Bedi S P S. Steroid therapy- current indications in practice. Ind J Anesth 2007;51(5):389-393.
36. Gupta P, Bhatia v. Corticosteroid physiology and principal of therapy. Ind J pediat 2008;(75):1039-1044.
37. Gulzar M A, Acharya A, Chaudhari R et al., Formulation and evaluation of in- situ gel containing Rosvastatin the treatment of periodontal diseases. J Pharm Res 2015;14(2):45-50.
38. Patel A, Shah D, Modasiya M et al., Development and evaluation of Cefpodoxime proxetil gellan gum based in-situ gel. IJPRBS 2012;1(2):179- 190.
39. Gulzar M A, Acharya A, Chaudhari R et al., Formulation and evaluation of in- situ gel containing Atrovastatin for the treatment of periodontal diseases. RGUHS J Pharm Sci 2015;5(2):57-60.
40. M K Patidar, F A Karjikar, F A Patel et al., Formulation and evaluation of mouth dissolving films of zolpidem tartrate by exploration on polymers combination. Int J Pharm 2013;3(4):716-721.
41. Aviral K, Prajapati S k et al., Formulation and evaluation of dental film for periodontaitis. IRJP 2012; 3(10):143-148.
2. Ratilal D.A, Priti G.D, Vidyadhar H.B. et al., A Review on: sustained released technology. Int J Res Apl Pha 2011;2(6):1701-08.
3. Patnaik N.A, Nagarjuna T.et al., Sustained release drug delivery system: A modern formulation approach. Int J Res Phar Nano 2013;2(5):586-601.
4. Mamidala R, Ramana v, Lingam M.et al., Review article factors influencing the design and performance of oral sustained/controlled release dosage form. Int J Phar Sci Nano 2009;(2): 583.
5. Lee V H L. Controlled drug delivery fundamental and application: Inf of drug prop desi 2008;(2):16-25.
6. Wani MS et al., Controlled release system: A review. European Industrial Pharmacy 2008;(6).
7. Kant A, Reddy S, Shankraiah M M. et al., In- situ gelling system-An overview pharmacology online 2011;(2): 28-44.
8. Miyazaki S, Endok, Kawasaki N.et al., Oral sustained delivery of paracetamol from in-situ gelling xyloglucan formulation. Drug Dev Ind Pharm 2003;29(2): 113-9.
9. Srividya B, Cardoza R M, Amin P D. Sustained ophthalmic delivery of ofloxicin from PH triggered in-situ gelling system. J Cont Releas 2001;73: 205-211.
10. Qiu Y, Park K. Environment- sensitive hydrogels for drug delivery. Adv Drug Del Rev 2001;53: 321-39.
11. Bhaskaran S, Lakshmi P.K, Harish C G. Topical ocular drug delivery- A review. Ind J Pharm Sci 2005;67(4):404-08.
12. Gupta H, Sharma A. Ion- activated bioadhesive in-situ gel of clindamycin for vaginal application. Int j Drug Delivery 2009;(1):32-40.
13. Jones M.A, Phili P B, Massermith. In-situ forming biomaterial, oral maxillofacial. Surg clin Amer 2002;(14):29-38.
14. Keshow, Miyazakis, Attwood D. Oral sustained delivery of Paracetamol form in-situ gelling gellan and sodium alginate formulation. Int J Pharm 2003;(258): 55-64.
15. Bertram U, Bodmeier R. In-situ gelling bioadhesive nasal inserts for extended drug delivery, in-vitro characterization of a new nasal dosage form. Eur J Pharm.Sci 2006;(27):62-71.
16. Varun R, Senthil V, Lavanya K et al., A Brief review on oral film technology IJRAP 2011;2(4):1138-1147.
17. Smriti T. Mouth dissolving film: A Review Int J Pharm Bio Sci 2013;4(1):899-908.
18. Liang A C, Chen, Li-Lan H. Fast dissolving intra-oral drug delivery system Expert openion 2001;11(6):981-986.
19. Corneille C. Quick dissolving strip:From concept of commercialization. Drug Delivery Tech 2006;6(2):68-71.
20. Kulakarni A S, Deokuli HA, Mane MS et al., Exploration of different polymers for use in the formulation of oral fast dissolving strip JCPR 2010;2(1):33-35.
21. Mahajan A, Chhabra N, Aggarwal G. Formulation and characterization of fast dissolving buccal film; A Review. Suhalari Res Libr Der Pharm letter 2011;3(1):158-160.
22. Kaur et al., A novel approach in oral fast dissolving drug delivery system-A Review A J Pharm Tec Res 2012;2(1):94-96.
23. Bhyan B, Jangra S,Kaur M et al., Orally fast dissolving films: Innovations in formulation and technology. Int JPhar Sci Res Rei 2011;9(2):50-57.
24. Patel D, Patel M, Opa dhyay P et al., A review on mouth dissolving film. IJSBR 2015;5(3):266-273.
25. Shashank N N, Bharani S Sogali, R S Thakur. Formulation and Evaluation Of pH-Triggered In Situ Ophthalmic Gel of Moxifloxacin Hydrochloride. International Journal of Pharmacy and Pharmaceutical Sciences 2012;4(2).
26. Paderni C, Compilato D et al., oral local drug delivery and new prospective in oral drug formulation. Oral Surg Oral Med Oral Patho Oral Radial 2012;114(3):25-34.
27. Tangri P, Satheesh Madhav NV. Oral mucoahesive drug delivery systems: A review. Int J Biopharmaceut, , 2011; 2(1):36-46..
28. Dr. Sukumar M. Lande, et all Luliconazole Loaded Electrospun Mucoadhesive Nanofiber: A Novel Nanoconstruct for The Treatment of Vulvovaginal Candidiasis, International Journal of Environmental Sciences, Vol. 11 No. 14s,2025.
29. Latheeshjla LL, Murala S, Mehul VJ, Swetha G, Phanitejaswini. Muccoadhesive drug delivery system: An overview. Int J Pharmtech Res. 2011; 3(1):42-49.
30. Paderni C, Compilato D, Giannola LI, Campisi G. Oral local drug delivery and new perspectives in oral drug formulation. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;114: e25-e34.
31. Mathew A K. Oral local drug delivery: An overview. Pharmacy and Pharmacology Res 2015;3(1):1-6
32. Barrons R W. Treatment strategies for recurrent oral aphthous ulcers. Am J Health Syst pharm 2001;58(1):41-50 .
33. Boras v v, N W Savage. Recurrent aphthous ulcerative disease: Presentation and management. AVS Dental J 2007;52(1):10-15.
34. Gibson N, Ferguson J W. Steroid cover for dental patients on long-term steroid indication: proposed clinical guidelines based upon a critical review of the literature. Brit Dent J 197(11):681-685.
35. Grover N K, Babu R, Bedi S P S. Steroid therapy- current indications in practice. Ind J Anesth 2007;51(5):389-393.
36. Gupta P, Bhatia v. Corticosteroid physiology and principal of therapy. Ind J pediat 2008;(75):1039-1044.
37. Gulzar M A, Acharya A, Chaudhari R et al., Formulation and evaluation of in- situ gel containing Rosvastatin the treatment of periodontal diseases. J Pharm Res 2015;14(2):45-50.
38. Patel A, Shah D, Modasiya M et al., Development and evaluation of Cefpodoxime proxetil gellan gum based in-situ gel. IJPRBS 2012;1(2):179- 190.
39. Gulzar M A, Acharya A, Chaudhari R et al., Formulation and evaluation of in- situ gel containing Atrovastatin for the treatment of periodontal diseases. RGUHS J Pharm Sci 2015;5(2):57-60.
40. M K Patidar, F A Karjikar, F A Patel et al., Formulation and evaluation of mouth dissolving films of zolpidem tartrate by exploration on polymers combination. Int J Pharm 2013;3(4):716-721.
41. Aviral K, Prajapati S k et al., Formulation and evaluation of dental film for periodontaitis. IRJP 2012; 3(10):143-148.
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Published
Feb 18, 2021
Article Details
How to Cite
Mr. Kiran M. Adchitre, Mr. Nadim S. Khan, Mr. Sukumar M. Lande, Mr. Hemant B. Bansode, & Mr. Sachin S. Pingale. (2021). COMPARATIVE STUDY OF HYDROCORTISONE IN-SITU GEL AND BUCCAL MUCOADHESIVE FILM FOR EFFECTIVE MANAGEMENT OF APHTHOUS ULCERS. Journal of Population Therapeutics and Clinical Pharmacology, 28(2), 1249-1260. https://doi.org/10.69980/1e2q3h66
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Author Biographies
Mr. Kiran M. Adchitre
Lecturer, Adarsh Shikshan Prasarak Mandal's, D. Pharmacy institute, Osmanabad.
Mr. Nadim S. Khan
Assistant Professor, Dattakala College of Pharmacy, Swami-Chincholi, Bhigwan (MH)
Mr. Sukumar M. Lande
Assistant Professor, Dattakala College of Pharmacy, Swami-Chincholi, Bhigwan (MH)
Mr. Hemant B. Bansode
Assistant Professor, Dattakala College of Pharmacy, Swami-Chincholi, Bhigwan (MH)
Mr. Sachin S. Pingale
Student, SET's College of Pharmacy, Dharwad.
How to Cite
Mr. Kiran M. Adchitre, Mr. Nadim S. Khan, Mr. Sukumar M. Lande, Mr. Hemant B. Bansode, & Mr. Sachin S. Pingale. (2021). COMPARATIVE STUDY OF HYDROCORTISONE IN-SITU GEL AND BUCCAL MUCOADHESIVE FILM FOR EFFECTIVE MANAGEMENT OF APHTHOUS ULCERS. Journal of Population Therapeutics and Clinical Pharmacology, 28(2), 1249-1260. https://doi.org/10.69980/1e2q3h66
