COMPARATIVE EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF SUBSTITUTED FLAVONES
Main Article Content
Keywords
Flavones, anti-inflammatory activity
Abstract
Objective: The flavonoids are a heterogeneous group of ubiquitous plant polyphenols that abound in the human diet and are endowed with several biological activities including anti-oxidant, anti-inflammmatory, immunomodulatory, antiviral, antimutagenic and anticarcinogenic properties. Flavones are believed to interfere with the different free radical-producing systems and enhance the functions of endogenous antioxidants. The aim of this study was to compare the antioxidant activity of synthesized substituted flavones by various free radical scavenging assays.
Method: The flavones used in the study, 6,3,4’ – trihydroxy flavones (THF) and 3-hydroxy-6,3’-dimethoxy flavones (DMF) were synthesized using standard procedures and their anti-inflammatory activity was compared by inhibition of protein denaturation and proteinase inhibitory activity. The anti-inflammatory activity of THF was found to be higher than that of the DMF, as THF produced higher percentage inhibition of proteinase activity and protein denaturation.
Results: The anti-arthritic activity of THF was found higher than that of the DMF, as the THF produced higher percentage inhibition of protein denaturation in lower concentrations also. The anti-inflammatory activity of THF was found higher than that of the DMF, as the THF produced higher percentage inhibition of proteinase activity.
Conclusion: From the study it can be seen that the flavones showed significant anti-inflammatory activity that can be used for treatment of various diseases.
References
2. Middleton E, Jr., Kandaswami C. The impact of plant flavonoids on mammalian biology:Implications for immunity, inflammation and cancer. In: Harborne JB, editor. The f lavonoid advances in research since1986. 1st edn. London: Chapman and Hall; 1994.p.619–652.
3. Harborne JB, Williams CA. Advances in flavonoid research since 1992. Phytochemistry 2000; 55:481–504.
4. Harleen Kaur Sandhar, Bimlesh Kumar, Sunil Prashant Tiwari, Manoj Salhan, Pradeep Sharma.A review of phytochemistry and pharmacology of flavonoids. Int Pharm J, 2011; vol 1(1): 25-41.
5. D. Procházková, I. Boušová, N. Wilhelmová.Antioxidant and prooxidant properties of flavanoids. Fitoterapia 82 (2011); 513–523.
6. Al-Khayri JM, Sahana GR, Nagella P, Joseph BV, Alessa FM, Al-Mssallem MQ. Flavonoids as potential anti-inflammatory molecules: A review. Molecules. 2022 May 2;27(9):2901.
7. NF Shamsudin, QU Ahmed, S Mahmood, SAA Shah, MN Sarian, MMAK Khattak, A Khatib. Flavonoids as antidiabetic and anti-inflammatory agents: A review on structural activity relationship-based studies and meta-analysis. International journal of molecular sciences, October 2022; 23:12605
8. Sakat S, Juvekar AR, Gambhire MN. In vitro antioxidant and anti-inflammatory activity of methanol extract of Oxalis corniculata Linn. International Journal of Pharma and Pharmacology Science. 2010; 2(1):146-155.
9. Oyedepo OO, Femurewa AJ. Anti‐protease and membrane stabilizing activities of extracts of Fagra zanthoxiloides, Olax subscorpioides and Tetrapleura tetraptera. International Journal of Pharmacongosy. 1995; 33:65‐69.
10. Rahman, H., C.M. Eswaraiah, K. Vakati and Inflammation Research, 44(1): 1-10. P. Madhavi, 2012. In-Vitro Studies Suggest Probable Mechanism Of Eucalyptus Oil For Anti-Inflammatory And Anti-Arthritic Activity. International Journal of Phytopharmacy, 2(3): 81-85
Article Sidebar
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Helen William
College of Pharmaceutical Sciences, Govt Medical College, Kottayam
Ajisha J L
College of Pharmaceutical Sciences, Govt Medical College, Trivandrum
