A Evaluation Result of Treatment Plans Used In the Treat of Right Breast Tumors After Mastectomy

Main Article Content

Saif Ameer Rashid Al-Hakkak
Mustafa Al-Musawi
Ammar Rasoul Mohammad

Keywords

breast cancer, dosimetry characteristics, IMRT organs at risk, VMAT

Abstract

Breast cancer is the most frequent cancer among women. Surgery, chemotherapy and radiotherapy are the main aspects of breast cancer management. External beam radiotherapy has an effective role in local recurrence control. The goal of this research is to determine if the volumetric arc therapy (VMAT) technique achieved a greater advantage in terms of homogeneous dose distribution for the tumor in comparison with intensity modulated radiotherapy (IMRT) technique and also in terms of reducing the dose on organ at risk in treatment patients with right breast cancer. Patients with right-sided breast cancer who underwent modified radical mastectomy were eligible for the study. Dose volume histograms were used to examine the dose distribution for both the planning target volume and the organs at risk. VMAT plans increase dose for PTV where 95% of prescribed dose cover 95% (V95) of Chest wall (PTV C. W) when compared with IMRT plans (P-Value 0.00387). Mean dose of heart was significantly decreased in IMRT plans when compared with VMAT plans (P – Value 0.00988) . The dose distribution of VMAT plans was the same as or better than IMRT plans, and it was linked to a significant benefit in ipsilateral lung sparing (P – Value 0.00318). Based on our data, patients with right-sided breast cancer who are candidates for modified radical mastectomy may benefit more from VMAT. Our results revealed that VMAT should be the first choice for patients with right-sided breast cancer who are undergoing modified radical mastectomy.

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References

Basco, V.E. et al. (1985) ‘Radiation dose and second breast cancer’, British journal of cancer, 52(3), pp. 319–325 .
Baskar, R. et al. (2012) ‘Cancer and radiation therapy: current advances and future directions’, International journal of medical sciences, 9(3), p. 193 .
Boice Jr, J.D. et al. (1992) ‘Cancer in the contralateral breast after radiotherapy for breast cancer’, New England Journal of Medicine, 326(12), pp. 781–785 .
Darby, S.C. et al. (2013) ‘Risk of ischemic heart disease in women after radiotherapy for breast cancer’, New England Journal of Medicine, 368(11), pp. 987–998 .
De Benedetto, D. et al. (2016) ‘Radiological anatomy of the breast’, Italian Journal of Anatomy and Embryology, pp. 20–36 .
Delaney, T.F. et al. (1992) ‘Cancer in the contralateral breast after radiotherapy for breast cancer’, New England Journal of Medicine, 327(6), pp. 430–432 .
Dumane, V.A. et al. (2014) ‘Dosimetric comparison of volumetric modulated arc therapy, static field intensity modulated radiation therapy, and 3D conformal planning for the treatment of a right-sided reconstructed chest wall and regional nodal case’, Journal of Radiotherapy, 2014 .
Goldhirsch, A. et al. (2013) ‘Personalizing the treatment of women with early breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013’, Annals of oncology, 24(9), pp. 2206–2223 .
Jagsi, R. et al. (2010) ‘Evaluation of four techniques using intensity-modulated radiation therapy for comprehensive locoregional irradiation of breast cancer’, International Journal of Radiation Oncology* Biology* Physics, 78(5), pp. 1594–1603 .
Low, C., Chen, Y. and Wu, M. (2011) ‘Understanding the determinants of cloud computing adoption’, Industrial management & data systems [Preprint] .
Ma, J. et al. (2013) ‘Post mastectomy linac IMRT irradiation of chest wall and regional nodes: dosimetry data and acute toxicities’, Radiation oncology, 8(1), pp. 1–10 .
McGuire, S. (2016) ‘World cancer report 2014. Geneva, Switzerland: World Health Organization, international agency for research on cancer, WHO Press, 2015’, Advances in nutrition, 7(2), pp. 418–419 .
Mestres, A. et al. (2017) ‘Knowledge-defined networking’, ACM SIGCOMM Computer Communication Review, 47(3), pp. 2–10 .
Park, J. et al. (2022) ‘Incidence of hypothyroidism after treatment for breast cancer: A Korean population-based study’, Plos one, 17(6), p. e0269893 .
Shimm, D.S. (2008) ‘Perez and Brady’s Principles and Practice of Radiation Oncology’, International Journal of Radiation Oncology, Biology, Physics, 72(4), p. 1268 .
Siegel, R.L., Miller, K.D. and Jemal, A. (2019) ‘Cancer statistics, 2019’, CA: a cancer journal for clinicians, 69(1), pp. 7–34 .
Sun, Y.-S. et al. (2017) ‘Risk Factors and Preventions of Breast Cancer’, International Journal of Biological Sciences, 13(11), pp. 1387–1397. Available at: https://doi.org/10.7150/ijbs.21635 .
Wang, R. et al. (2022) ‘Dosimetric comparison between intensitymodulated radiotherapy and volumetricmodulated arc therapy in patients of left-sided breast cancer treated with modified radical mastectomy CONSORT’, Medicine (United States). Available at:
https://doi.org/10.1097/MD.0000000000028427.