The correlation between Bradykinin and Leukotreine with Glutathione in Patients with COVID19

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Ali M. A. Al-Kufaishi
Maryam A. J. Al-Hasnawi


COVID-19, Bradykinin, Leukotrienes, Glutathione, Oxidative stress


In Dec 2019 in Wuhan, China, several acute atypical respiratory diseases were brought on by a novel coronavirus that is currently known as SARS-CoV-2. A worldwide pandemic has been caused by the virus spreading from person to person. Numerous countries have been forced to enact public isolation and lockout as the death toll keeps mounting. There is still a need for therapeutic strategies, which is a problem. According to statistical data, senior people are more vulnerable to serious illnesses than children, who often experience minimal side effects. Assessment and study the correlation of bradykinin, leukotrienes B4 and D4 with glutathione for patients with COVID-19 compared to a healthy controlled study, with results that were interpreted scientifically. Ninety individuals, separated into a sick group and a healthy group, had blood samples taken. An analysis of demographic data, including gender, age, clinical severity, blood oxygen saturation, and body mass index, depending on the exclusion criteria for people with asthma, diabetics, pregnant women, and those with heart disease. Bradykinin and leukotriene B4 and D4 levels were estimated using enzyme-linked immunosorbent assay (ELISA), and glutathione measured by spectrophotometry method. The results manifest that the levels of bradykinin and leukotrienes B4, and D4 increased in significant values in the patients with COVID-19 compared with healthy control with a decrease in the values of glutathione the same comparison. Also, there is a negative correlation for glutathione with other
parameters that were studied. Through the results shown in the study, it can be considered leukotrienes B4, D4, and bradykinin are very important for evaluating the functions of the lungs, as well as it is possible to give the specialist an important idea about the extent of the deterioration of the patient’s condition, and thus facilitate the appropriate treatment strategy for him.

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