Evaluation of autoimmune biomarkers in vitiligo patients' serum

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Ekhlas A. K. Kanani
Awatif H. Issa
Khalil I. Al-Hamdi


C-reactive protein (hsCRP) and C-reactive protein (CRP) in


Background: Vitiligo is one of the diseases which its pathogenesis has not yet been clearly understood, however many studies underline this disease as an autoimmune. The majority of authority preferred the autoimmune origins due to the substantial correlations between vitiligo and other autoimmune disorders, as well as having autoantibodies. The presence of antinuclear antibodies in vitiligo patients appear to support an autoimmune involvement in the disease's etiology. Aim of the study: investigation the prevalence and significance of antinuclear antibodies ANAs, high sensitivity C-reactive protein (hsCRP) and C-reactive protein (CRP) in vitiligo patients compared with healthy subjects. Methods: Ninety sera specimens from (45 vitiligo patients with matched 45 healthy controls) were analyzed in this study for Euroline ANA profile 23 (IgG) , hsCRP and CRP tests. Results: There were statistically significant positive findings of ANA in vitiligo patients in comparsion with controls subjects. Anti-RP-155 was the most prevalent in patients. In addition to high positive findings of hsCRP and CRP tests related to patients than controls. Conclusion: The study supports a significant association between vitiligo and other autoimmune diseases. Identification and characterization of anti-nuclear autoantibodies in vitiligo patients considered vital indicators support the findings of the most other researches indicating this disease is an autoimmune disease, and can pave the way for identifying the extent possible incidence of other autoimmune diseases, to take the appropriate medical procedure to avoid the exacerbation of diseases. ANAs findings supported with high positive findings of hsCRP and CRP proteins that might have a role in vitiligo pathogenesis. 

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