Comparative Evaluation of Efficacy of Antibiotics incorporated Platelet Rich Fibrin Versus Platelet Rich Fibrin alone in the Treatment of Intrabony Defects
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Keywords
Platelet rich fibrin, intrabony defects, antibiotics, amoxicillin
Abstract
Background: Platelet rich fibrin (PRF) is regarded as second generation platelet concentrate which is widely used to treat intraosseous defects. Bacterial contamination in periodontal regeneration is prevented by systemic antibiotics which may give rise to drug resistance and other side effects. Aim: The study aimed to explore clinical and radiographic effectiveness of amoxicillin incorporated PRF in the management of intrabony defects. Methods: Sixteen intrabony defects were treated with either Amoxicillin incorporated PRF (test site) or PRF alone (control site). Clinical parameters such as probing pocket depth (PPD), relative attachment level (RAL) and relative gingival margin level (RGML) were recorded at baseline and 6 months post-operatively. Wound healing index (WHI) was
assessed at 7 and 14 days post-operatively. The defect fill at baseline and 6 months was calculated using cone beam computed tomography (CBCT). Results: On intergroup comparison of mean PPD, RAL and RGML showed no statistically significant difference. Comparison of WHI between control group and test group showed significant healing at 7 days post-operatively. Defect fill change
showed no significant difference between control and test groups from baseline to 6 months. Conclusion: Both the groups seem to be effective in the treatment of intrabony defects. Initial wound healing was better in test group. However, randomized controlled trials with larger sample size are required to evaluate the efficacy of amoxicillin incorporated PRF in periodontal regeneration
References
Biomaterials. 2010;31(31):7892-927.
2. Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, Gogly B. Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part I: Technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101:e37-44.
3. Choukroun J, Diss A, Simonpieri A, Girard MO, Schoeffler C, Dohan SL, Dohan AJ, Mouhyi J, Dohan DM. Platelet-rich fibrin (PRF): a secondgeneration platelet concentrate. Part V: histologic evaluations of PRF effects on bone allograft maturation in sinus lift. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101(3):299-303.
4. Miron RJ, Pikos MA. PRF as a barrier membrane in guided bone regeneration. Dent Today. 2017;36:1-9.
5. Polak D, Clemer‐Shamai N, Shapira L.. Incorporating Antibiotics into Platelet Rich Fibrin (PRF): A Novel Antibiotics Slow Release Biological Device. J Clin Periodontol. 2019;46(2):241-247.
6. Löe, H. The Gingival Index, the Plaque Index and the Retention Index Systems. J Periodontol 1967;38(6), 610–616
7. Muhlemann HR. Gingival sulcus bleeding-a leading symptom in initial gingivitis. Helv Odontol Acta. 1971;15:107-13.
8. Huang LH, Neiva RE, Wang HL. Factors affecting the outcomes of coronally advanced flap root coverage procedure. J Periodontol. 2005;76:1729–1734.
9. Hung SL, Lin YW, Chen YT, Ling LJ. Attachment of periodontal ligament cells onto various antibiotics-loaded GTR membranes. Int J
Periodontics Restorative Dent. 2005;25(3):265-75
10. Cheng CF, Wu KM, Chen YT, Hung SL. Bacterial adhesion to antibiotic-loaded guided tissue regeneration membranes - a scanning
electron microscopy study. J Formos Med Assoc. 2015;114(1):35-45.
11. Bielecki T, Gazdzik TS. Antimicrobial Activity of Platelet-rich gel after Antibiotic administration–a preliminary report. https://boneandjoint.org.uk/article/10.1302/0301-620X.91BSUPP_I.0910131.
12. Pradeep AR, Rao NS, Agarwal E, Bajaj P, Kumari M, Naik SB. Comparative evaluation of autologous platelet-rich fibrin and platelet-rich plasma in the treatment of 3-wall intrabony defects in chronic periodontitis: a randomized controlled clinical trial. J Periodontol. 2012;83(12):1499-507
13. Sharma A, Pradeep AR. Treatment of 3-Wall Intrabony Defects in Patients With Chronic Periodontitis With Autologous Platelet-Rich Fibrin: A Randomized Controlled Clinical Trial. J Periodontol. 2011;82(12):1705-12
14. Thorat M, Pradeep AR, Pallavi B. Clinical effect of autologous platelet-rich fibrin in the treatment of intra-bony defects:a controlled clinical trial. J Clin Periodontol 2011;38: 925–932.
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