FASTING BLOOD GLUCOSE LEVELS IN NORMAL VERSUS STRESSED PREGNANT TEENAGERS
Main Article Content
Keywords
Adolescent pregnancy, psychological stress, fasting blood glucose
Abstract
Background: Teenage pregnancy is a major public health issue and carries an increased risk in the development of metabolic complications. There is little data for the effect of psychological stress on glucose metabolism in this high-risk group.
Objective: To assess the relationship between psychological stress and fasting blood sugar levels in pregnant teenagers.
Methodology: This is a cross-sectional study performed from June 2023 to May 2024. A total of 263 pregnant adolescents ((13-19 year) ANC attendees at Gynecology and Obstetrics OPDs in the selected healthcare facilities of Hyderabad and Jamshoro. The subjects were divided into the normal stress group (n=101) and stressed group (n=162). Fasting blood glucose was categorized as normal (≤95 mg/dL) or high risk (>95 mg/dL). Chi-square test was used at p < 0.05 level.
Results: Higher proportion of elevated fasting glucose was observed in the stressed (72.85 %) versus normal stress group (30.70 %). The chi-square test was χ² = 43.30 (p < 0.0001). Pregnant adolescents who were under stress showed higher odds of gestational elevated glucose (OR = 6.05 95% CI: 3.506–10.46).
Conclusion: Psychological stress is closely linked with glucose dysregulation among pregnant adolescents. Incorporating stress evaluation and interventions for stress reduction into prenatal care of adolescents may lead to improved metabolic health and prevent gestational metabolic sequelae.
References
2. Morton A, Teasdale S. Physiological changes in pregnancy and their influence on the endocrine investigation. Clinical endocrinology. 2022;96(1):3-11.
3. Bano S, Agrawal A, Asnani M, Das V, Singh R, Pandey A et al. Correlation of insulin resistance in pregnancy with obstetric outcome. The Journal of Obstetrics and Gynecology of India. 2021;71(5):495-500.
4. Kawakita T, Wilson K, Grantz KL, Landy HJ, Huang CC, Gomez-Lobo V. Adverse maternal and neonatal outcomes in adolescent pregnancy. Journal of pediatric and adolescent gynecology. 2016;29(2):130-6.
5. Santana DS, Cecatti JG, Surita FG, Silveira C, Costa ML, Souza RT, et al. Maternal near miss and adverse perinatal outcome among adolescent pregnant women: results from the World Health Organization Multicountry Survey on Maternal and Newborn Health. Eur J Obstet Gynecol Reprod Biol. 2017;209:21-27.
6. Bjelica A, Cetkovic N, Trninic-Pjevic A, Mladenovic-Segedi L. The phenomenon of pregnancy A psychological view. Ginekologia polska. 2018;89(2):102-6.
7. Staneva A, Bogossian F, Pritchard M, Wittkowski A. The effects of maternal depression, anxiety, and perceived stress during pregnancy on preterm birth: a systematic review. Women Birth. 2015;28(3):179-193.
8. Thorp AA, Owen N, Neuhaus M, Dunstan DW. Sedentary behaviors and subsequent health outcomes in adults: a systematic review of longitudinal studies, 1996-2011. Am J Prev Med. 2011;41(2):207-215.
9. Abraham S, Rubino D, Sinaii N, Ramsey S, Nieman LK. Cortisol, obesity, and the metabolic syndrome: A cross‐sectional study of obese subjects and review of the literature. Obesity. 2013;21(1):E105-17.
10. Duthie L, Reynolds RM. Changes in the maternal hypothalamic-pituitary-adrenal axis in pregnancy and postpartum: influences on maternal and fetal outcomes. Neuroendocrinology. 2013;98(2):106-15.
11. Tamás P, Sulyok E, Szabó I, Vizer M, Ertl T, Rascher W, Blum WF. Changes of maternal serum leptin levels during pregnancy. Gynecologic and obstetric investigation. 1998;46(3):169-71.
12. Munck A, Guyre PM, Holbrook NJ. Physiological functions of glucocorticoids in stress and their relation to pharmacological actions. Endocr Rev. 1984;5(1):25-44.
13. Romeo RD. The teenage brain: the stress response and the prefrontal cortex. Curr Dir Psychol Sci. 2013;22(2):140-145.
14. Elenkov IJ. Glucocorticoids and the Th1/Th2 balance. Ann N Y Acad Sci. 2004;1024:138-146.
15. Freyberg Z, Gittes GK. Roles of pancreatic islet catecholamine neurotransmitters in glycemic control and in antipsychotic drug–induced dysglycemia. Diabetes. 2023;72(1):3-15.
16. Barbour LA, McCurdy CE, Hernandez TL, Kirwan JP, Catalano PM, Friedman JE. Cellular mechanisms for insulin resistance in normal pregnancy and gestational diabetes. Diabetes Care. 2007;30 Suppl 2:S112-S119.
17. Leoni M, Padilla N, Fabbri A, Della-Morte D, Ricordi C, Infante M. Mechanisms of Insulin Resistance during Pregnancy. InEvolving Concepts in Insulin Resistance 2022. IntechOpen.
18. Newbern D, Freemark M. Placental hormones and the control of maternal metabolism and fetal growth. Curr Opin Endocrinol Diabetes Obes. 2011;18(6):409-416.
19. Zhou J, Han J. Association of niacin intake and metabolic dysfunction-associated steatotic liver disease: findings from National Health and Nutrition Examination Survey. BMC Public Health. 2024;24(1):2742.
20. Ke P, Jiang H, Dowling R, Zhong L, Ke L, Xu M, et al. Relationship between dietary niacin intake and diabetes mellitus in the National Health and Nutrition Examination Survey (NHANES) 2003–2018. Eating and Weight Disorders-Studies on Anorexia, Bulimia and Obesity. 2022;27(7):2425-34.
21. Renner V, Joraschky P, Kirschbaum C, Schellong J, Petrowski K. Pro-and anti-inflammatory cytokines Interleukin-6 and Interleukin-10 predict therapy outcome of female patients with posttraumatic stress disorder. Translational psychiatry. 2022;12(1):472.
22. Renner V, Schellong J, Bornstein S, Petrowski K. Stress-induced pro-and anti-inflammatory cytokine concentrations in female PTSD and depressive patients. Translational psychiatry. 2022;12(1):158.
23. Yan K. Recent advances in the effect of adipose tissue inflammation on insulin resistance. Cellular Signalling. 2024;120:111229.
24. Jagtap A, Jagtap B, Jagtap R, Lamture Y, Gomase K. Effects of prenatal stress on behavior, cognition, and psychopathology: A comprehensive review. Cureus. 2023;15(10):e47044.

