SYNTHESIS, CHARACTERIZATION,BIOLOGICAL ACTIVITY AND METAL COMPLEXING PROPERTIES OF LIGANDS WITH DERIVED FROM HYDRALAZINE DRUG AND CHLORO SUBSTITUTED SALICYLALDEHYDE
Main Article Content
Keywords
Hydralazine drug, Ligands, Schiff base, Salicylaldehyde, Metal Complexes, Spectral studies, Magnetic and Antimicrobial activity.
Abstract
Hydrazone ligands viz; 4-chloro-2-((2-(phthalazin-1-yl)hydrazono)methyl)phenol (PCP) and 2,4-dichloro-6-((2-(phthalazin-1-yl)hydrazono)methyl)phenol (PDP) were prepared by condensation of Hydralazine drug respectively with 5-chlorosalicylaldehyde (CS) and 3,5-Dichloro salicylaldehyde (DCS). The synthesised ligands and their Cu 2+,Ni2+ and Co2+ metal complexes have been analysed by elemental content, spectral features, magnetic moment molar conductance and thermo gravimetry. The analytical data show that complexes show 1:1(M:L) ratio, the magnetic moment consistent with predicted structure. All the compounds have been screened for their antimicrobial activity against common microbes.
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Kirti Salame
Research Scholar, Department of Chemistry, Government MLB Girls’ PG Autonomous College Bhopal, M.P., India
Arun Singh
Professor, Department of Chemistry, Government MLB Girls’ PG Autonomous College Bhopal, M.P.,India, Email ID: [email protected]
