CORRELATION BETWEEN 1-MIN-SIT-TO-STAND TEST AND 6-MIN WALK TEST FOR EVALUATION OF CARDIORESPIRATORY PARAMETERS IN PATIENTS WITH INTERSTITIAL LUNG DISEASE.

Abstract

Background: -

Six-minute Walk Test (6MWT) is frequently used in patients with Interstitial Lung Disease (ILD’s) but requires infrastructural requirements and 1 minute sit to stand test (1STST) has emerged as recent exercise testing modality. But evidence for use of 1STST in ILD patients as a substitute for 6MWT is limited. The study was conducted to evaluate the performance of serial repetition of 1STST by correlating it with 6MWT in ILD patients as well as to compare the effects of these tests on cardiorespiratory parameters in ILD patients.

The Six-minute Walk Test (6MWT) is commonly used in Interstitial Lung Disease (ILD) patients but requires specific infrastructure. The one-minute sit-to-stand test (1STST) has emerged as an alternative, though evidence in ILD is limited. This study evaluated serial 1STST performance by correlating it with 6MWT and comparing their effects on cardiorespiratory parameters in ILD patients.

Material and methods: -

Prospective cross-over study conducted on eighty stable ILD patients (male±female) with mean age 54.8 ± 9.23 who after initial spirometry underwent two repetitions each of 6MWT and 1STST on same day with washout interval of 30 minutes with intervention order generated through computer generated list. Functional capacity and cardiorespiratory parameters including heart rate, pulse oxygen saturation, blood pressure, dyspnea including peripheral oxygen saturation (Nadir SpO2) were correlated after the tests using Pearson correlation and Intraclass correlation coefficient (ICC).

Results: -

Repetitions after 1STST showed significant correlation with 6MWT distance [1^st test:- r=0.88; p value:- 0.013**]; [2^nd test:- r=0.28;p value:- 0.013**]. Both lowest SpO2 and difference in SpO2 also showed good agreement. Lowest SpO2 (ICC=0.62; 95% confidence interval [CI]=0.47–0.74 and ICC=0.81; 95% CI=0.71–0.87 respectively) and significant correlation (r = 0.29 and r = 0.34, respectively)

Conclusion: -

The findings concluded that there is strong correlation between the performance of 1STST and 6MWT and effect of these exercise tests on common respiratory variables including HR, SBP, DBP, SpO₂, dyspnea and NADIR SpO₂ in cohort of ILD’s patients in age range 45-70 years and with moderate degree of ILD. 1STST can be a valid alternative to 6MWT in evaluation of ILD patients.