COMPARISON OF JAUNDICE AND PHOTOTHERAPY IN NEONATES OF METFORMIN VS INSULIN TREATED GDM MOTHERS
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Keywords
Gestational Diabetes Mellitus, Jaundice, Phototherapy, Diabetes Mellitus
Abstract
Background: Gestational diabetes mellitus (GDM) can affect neonatal outcomes, including the development of hyperbilirubinemia. This case study evaluates the severity of jaundice and the need for phototherapy in neonates born to mothers with GDM who were treated with either metformin or insulin.
Methods: This case series included 50 neonates born to mothers diagnosed with GDM, divided equally into two groups: the metformin group (n = 25) and the insulin group (n = 25). The primary outcomes assessed were the peak total serum bilirubin (TSB) levels within the first seven days of life and the requirement for phototherapy. Secondary outcomes included the age at initiation of phototherapy, duration of phototherapy, incidence of exchange transfusion, and other relevant neonatal variables. Statistical analyses were performed using the t-test or Mann–Whitney test for continuous variables, and the chi-square test for categorical variables.
Results: The mean peak TSB in the metformin group was 10.4 ± 2.1 mg/dL, compared to 11.1 ± 2.6 mg/dL in the insulin group. Phototherapy was required in 6 (24%) of neonates in the metformin group and 8 (32%) in the insulin group.
Conclusion: After adjusting for confounding factors, no significant differences were observed between the groups in terms of peak TSB levels or phototherapy rates.
References
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Vasant Shrivastava
Associate Professor, Department of General Medicine, Ram Krishna Medical College Hospital and Research Center, Bhopal. Email: [email protected]
Pooja Shrivastava
Gynecologist and Obstetrician, Lotus Hospital, Bhopal. Email: [email protected]
Gaurav Shrivastava
Assistant Professor, Department of Pediatrics, Ram Krishna Medical College Hospital and Research Center, Bhopal. Email: [email protected]
