EFFECTIVENESS OF GOAL-DIRECTED THERAPY VS MASSIVE TRANSFUSION PROTOCOL IN A TERTIARY CARE CENTER IN SOUTH INDIA
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Keywords
ROTEM, CCT, Coagulation, Rotational thromboelastometry
Abstract
A comparative study was done, wherein the retrospective data were collected from the institutional MTP registry and compared with prospective data of patients managed by Goal-Directed Therapy using ROTEM.
Data about patient demographics, mode of admission, indication for massive transfusion, blood component usage, Morbidity, and mortality of 122 patients were collected and analyzed.
MTP was activated for PPH, Trauma & surgery at a rate of 45%, 36.1% & 11.5%. Goal-directed Therapy was initiated mainly for Trauma, surgery, PPH & snake bite at a rate of 42.6%, 23%, 19.7%, and 4.9% respectively. There was a significant reduction in blood component utilization for PRBC, FFP & platelet(p<0.05) in GDT, but cryoprecipitate utilization remained the same.
There was a significant reduction in morbidity measured as the length of hospital stay (Sig=0.038) for patients managed by GDT (9.39 days) in comparison to those managed by MTP (17.05 days). There was no statistical difference in mortality among the comparison groups.
From the data, we were able to conclude that Goal-directed therapy shows a significant reduction in blood component utilization & morbidity without a significant change in mortality among patients in this study.
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All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Dr Arun V J
MD Transfusion Medicine Department, Assistant Professor, Malabar Medical College Hospital and Research Centre, Calicut, India
Dr Krishna Raj J S
MD Community Medicine Department, Associate Professor, Malabar Medical College Hospital and Research Centre, Calicut, India
Dr Kanniyan Binub
MD Community Medicine Department, Professor, Malabar Medical College Hospital and Research Centre, Calicut, India
Dr Susheela J Innah
Lab Director, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala
Dr. Aboobacker Mohamed Rafi
MD Transfusion Medicine Department, Associate Professor, Jubilee Mission Medical College & Research Institute in Thrissur, Kerala
