EXPLORING THE USE OF TENOXICAM AS A SINGLE-DOSE ANALGESIC FOR POST-ORAL SURGERY PAIN RELIEF
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Keywords
Tenoxicam, Post-oral surgery, Analgesic, Pain relief
Abstract
The proposed study was designed to assess the efficacy of tenoxicam with paracetamol and code as the added analgesics in management of postoperative pain after oral surgery. One hundred and seventy-five patients who had the surgical extraction of at least both inferior third molars were randomly assigned to use of placebo, tenoxicam 20 mg, and tenoxicam 40 mg, and up to 2 Panadeine tablets (paracetamol- 5mg and codeine- 8mg per tablet) every 4 hours. Pain was assessed using a 100-mm visual analogue scale (VAS) during follow-up immediately after the surgery and 1-5 days. Pain severity was observed as a principal outcome, whereas sleep disturbance and medication use were observed as secondary outcomes. There was a significant decrease in pain at rest and sleep disturbance in tenoxicam compared to the placebo group, although the patients took fewer Panadeine tablets. The experiment was carried out to compare analgesic efficacy of both doses (20 mg and 40 mg) of tenoxicam with no significant variations in the analgesic effect. More incidences of sedation were reported among the T40 group though there were no major adverse effects reported in both groups. The rate of nausea and vomiting was comparable in all the groups, which are in agreement with other researches done on the use of NSAIDs perioperative. There were no major adverse events reported indicating that tenoxicam as an add-on to Panadeine is a safe and effective way of giving postoperative pain. No assessment of preemptive analgesia was actually planned in the study, but a comparison of those patients who received local anaesthetic to those who did not did indeed indicate no significant difference in postoperative pain outcome after one hour. In general, the tenoxicam and Panadeine combination were more effective in pain relief compared to paracetamol and codeine alone, but further trials to evaluate the long-term efficiency and safety should be performed.
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Dr. Kumara Raghavendra Varma
Assistant Professor, Department of General Surgery, Sri Devaraj URs Medical College, Kolar, Karnataka, India.
Dr. Gawtham D
Assistant Professor, Department of General Surgery, Sri Lakshmi Narayana Institute of Medical Science, Pondicherry, India
