A CROSS-SECTIONAL STUDY TO DETERMINE THE ENDOSCOPIC FINDINGS IN PATIENTS WITH PPI RESISTANT DYSPEPSIA IN A TERTIARY CARE CENTRE
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Abstract
Background: Dyspepsia, a common condition marked by upper abdominal discomfort, significantly affects quality of life. While proton pump inhibitors (PPIs) are the standard treatment, a substantial number of patients experience persistent symptoms, a condition known as PPI-resistant dyspepsia. The underlying causes of this resistance are complex and not fully understood, highlighting the need for further investigation, particularly through upper gastrointestinal (GI) endoscopy.
Aim: This cross-sectional study was conducted to determine the endoscopic findings in patients with PPI-resistant dyspepsia at a tertiary care centre. The primary objective was to identify the etiologies causing PPI resistance, while a secondary objective was to determine if associated comorbidities influence this resistance.
Materials and Methods: A total of 71 patients were enrolled in the study. All participants underwent a comprehensive evaluation, including a detailed clinical history, physical examination, and upper GI endoscopy. The study recorded demographic data, presenting symptoms, duration of symptoms, PPI usage, and associated comorbidities. Endoscopic findings were meticulously documented to identify both organic and functional abnormalities.
Results: The mean age of the participants was 41.25 years, with a female predominance (54.9%). The most common presenting symptoms were epigastric burning (97.2%), abdominal pain (94.4%), and bloating (90.1%). Endoscopic evaluation revealed a high prevalence of abnormal findings, with gastritis being the most common observation, followed by esophagitis and peptic ulcers. The study also found that a significant portion of patients had conditions such as H. pylori infection.
Conclusion: The findings of this study demonstrate that a significant number of patients with PPI-resistant dyspepsia have identifiable organic causes, which can be diagnosed through upper GI endoscopy. The results highlight the diagnostic utility of endoscopy in this patient population, as it can reveal underlying pathologies that necessitate a change in management strategy beyond standard acid suppression therapy. These findings support the hypothesis that endoscopic evaluation is a valuable tool for tailoring individualized treatment plans and improving outcomes for patients with PPI-resistant dyspepsia.
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Dr. Abhishek
Department of Medical Gastroenterology, [NIMS&R], Jaipur, Rajasthan, India
Dr. Shivangi Gupta
Department of Nephrology, [NIMS&R], Jaipur, Rajasthan, India
Dr Naman Bansal
Department of Medical Gastroenterology, [NIMS&R], Jaipur, Rajasthan, India
Dr. Prashanth.k
Department of Medical Gastroenterology, [NIMS&R], Jaipur, Rajasthan,
Dr. Buddhi Prakash Meena
Department of Medical Gastroenterology, [NIMS&R], Jaipur, Rajasthan, India
Dr. Mohan B Goyal
Department of Medical Gastroenterology, [NIMS&R], Jaipur, Rajasthan, India
Dr. Rakesh Kochhar
Department of Medical Gastroenterology, [NIMS&R], Jaipur, Rajasthan, India
