EVALUATION OF CHEST X-RAY FINDINGS IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE: A CROSS-SECTIONAL STUDY AT A TERTIARY CARE CENTER
Main Article Content
Keywords
Chronic Obstructive Pulmonary Disease, Chest Radiography, Emphysema, Spirometry, Hyperinflation
Abstract
Chronic Obstructive Pulmonary Disease (COPD) represents a major global health burden characterized by persistent airflow limitation. While spirometry remains the gold standard for diagnosis, chest radiography provides valuable complementary information for disease phenotyping and assessment. This study aimed to evaluate the spectrum of chest X-ray findings in COPD patients and correlate these with clinical and spirometric parameters.
Methods: A hospital-based cross-sectional observational study was conducted at Saraswathi Institute of Medical Sciences, Anwarpur, Uttar Pradesh, from March 2021 to August 2021. A total of 142 spirometrically confirmed COPD patients aged 40 years and above were enrolled using consecutive sampling. Detailed clinical history, spirometry, and standardized chest radiographs (posteroanterior and lateral views) were obtained. Radiographic findings were systematically evaluated and correlated with GOLD staging and spirometric parameters using appropriate statistical tests.
Results: The study population had mean age 62.4±9.8 years with 87.3% males. Hyperinflation was the most common radiographic finding (76.1%), followed by flattened diaphragm (67.6%), vascular pruning (54.9%), and bullae (36.6%). Only 9.9% had normal chest X-rays. Significant correlations existed between radiographic findings and COPD severity (p<0.001). Patients with hyperinflation had significantly lower FEV1% predicted (48.6% vs 68.4%, p<0.001) compared to those without. Progressive increase in radiographic abnormalities correlated with worsening GOLD stages.
Conclusion: Chest X-ray abnormalities are highly prevalent in COPD patients and correlate significantly with disease severity and spirometric impairment. Chest radiography remains a valuable complementary tool for COPD phenotyping and assessment alongside spirometry.
References
2. Fujimoto, K., Kitaguchi, Y., Kubo, K., & Honda, T. (2006). Clinical analysis of chronic obstructive pulmonary disease phenotypes classified using high-resolution computed tomography. Respirology, 11(6), 731-740. https://doi.org/10.1111/j.1440-1843.2006.00930.x
3. Global Initiative for Chronic Obstructive Lung Disease. (2020). Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: 2020 report. https://doi.org/10.15326/jcopdf.7.1.2019.0139
4. Graham, B. L., Steenbruggen, I., Miller, M. R., Barjaktarevic, I. Z., Cooper, B. G., Hall, G. L., Hallstrand, T. S., Kaminsky, D. A., McCarthy, K., McCormack, M. C., Oropez, C. E., Rosenfeld, M., Stanojevic, S., Swanney, M. P., & Thompson, B. R. (2019). Standardization of spirometry 2019 update: An official American Thoracic Society and European Respiratory Society technical statement. American Journal of Respiratory and Critical Care Medicine, 200(8), e70-e88. https://doi.org/10.1164/rccm.201908-1590ST
5. Greene, R. (1978). The radiological spectrum of pulmonary emphysema. Medical Clinics of North America, 62(4), 717-731. https://doi.org/10.1016/S0025-7125(16)31807-5
6. Gupta, P. P., Yadav, R., Verma, M., & Agarwal, D. (2009). High-resolution computed tomography features in patients with chronic obstructive pulmonary disease. Singapore Medical Journal, 50(2), 193-200.
7. Hida, T., Yamada, Y., Ueyama, M., Araki, T., Nishino, M., Kurosaki, A., Jinzaki, M., Honda, H., Hatabu, H., & Kudoh, S. (2019). Decreased and slower diaphragmatic motion during forced breathing in severe COPD patients: Time-resolved quantitative analysis using dynamic chest radiography with a flat panel detector system. European Journal of Radiology, 112, 28-36. https://doi.org/10.1016/j.ejrad.2018.12.023
8. Jindal, S. K., Aggarwal, A. N., Gupta, D., Agarwal, R., Kumar, R., Kaur, T., Chaudhry, K., & Shah, B. (2012). Indian study on epidemiology of asthma, respiratory symptoms and chronic bronchitis in adults (INSEARCH). International Journal of Tuberculosis and Lung Disease, 16(9), 1270-1277. https://doi.org/10.5588/ijtld.12.0005
9. Makita, H., Nasuhara, Y., Nagai, K., Ito, Y., Hasegawa, M., Betsuyaku, T., Onodera, Y., Hizawa, N., Nishimura, M., & Hokkaido COPD Cohort Study Group. (2007). Characterisation of phenotypes based on severity of emphysema in chronic obstructive pulmonary disease. Thorax, 62(11), 932-937. https://doi.org/10.1136/thx.2006.072777
10. Mets, O. M., de Jong, P. A., van Ginneken, B., Gietema, H. A., & Lammers, J. W. (2012). Quantitative computed tomography in COPD: Possibilities and limitations. Lung, 190(2), 133-145. https://doi.org/10.1007/s00408-011-9353-9
11. Miniati, M., Filippi, E., Falaschi, F., Carrozzi, L., Milne, E. N., Sostman, H. D., & Pistolesi, M. (1995). Radiologic evaluation of emphysema in patients with chronic obstructive pulmonary disease: Chest radiography versus high resolution computed tomography. American Journal of Respiratory and Critical Care Medicine, 151(5), 1359-1367. https://doi.org/10.1164/ajrccm.151.5.7735583
12. Miniati, M., Monti, S., Stolk, J., Mirarchi, G., Falaschi, F., Rabinovich, R., Canapini, C., Roca, J., & Rabe, K. F. (2008). Value of chest radiography in phenotyping chronic obstructive pulmonary disease. European Respiratory Journal, 31(3), 509-515. https://doi.org/10.1183/09031936.00095607
13. O'Brien, C., Guest, P. J., Hill, S. L., & Stockley, R. A. (2000). Physiological and radiological characterisation of patients diagnosed with chronic obstructive pulmonary disease in primary care. Thorax, 55(8), 635-642. https://doi.org/10.1136/thorax.55.8.635
14. Parasuramalu, B. G., Huliraj, N., Prashanth Kumar, S. P., Gangaboraiah, Ramesh Masthi, N. R., & Srinivasa Babu, C. R. (2014). Prevalence of chronic obstructive pulmonary disease and its association with tobacco smoking and environmental tobacco smoke exposure among rural population. Indian Journal of Public Health, 58(1), 45-49. https://doi.org/10.4103/0019-557X.128166
15. Pratt, P. C. (1987). Role of conventional chest radiography in diagnosis and exclusion of emphysema. American Journal of Medicine, 82(5), 998-1006. https://doi.org/10.1016/0002-9343(87)90165-0
16. Raoof, S., Amchentsev, A., Vlahos, I., Goud, A., & Naidich, D. P. (2012). Pictorial essay: Multinodular disease: A high-resolution CT scan diagnostic algorithm. Chest, 141(6), 1722-1733. https://doi.org/10.1378/chest.11-0917
17. Shiraishi, M., Higashimoto, Y., Sugiya, R., Mizusawa, H., Takeda, Y., Noguchi, M., Nishiyama, O., Yamazaki, R., Kudo, S., Kimura, T., Tohda, Y., & Matsumoto, H. (2020). Diaphragmatic excursion correlates with exercise capacity and dynamic hyperinflation in COPD patients. ERJ Open Research, 6(4), 00589-2020. https://doi.org/10.1183/23120541.00589-2020
18. Sinha, B., Vibha, Singla, R., & Chowdhury, R. (2017). An epidemiological profile of chronic obstructive pulmonary disease: A community-based study in Delhi. Journal of Postgraduate Medicine, 63(1), 29-35. https://doi.org/10.4103/0022-3859.194200
19. Sutinen, S., Christoforidis, A. J., Klugh, G. A., & Pratt, P. C. (1965). Roentgenologic criteria for the recognition of nonsymptomatic pulmonary emphysema: Correlation between roentgenologic findings and pulmonary pathology. American Review of Respiratory Disease, 91(1), 69-76. https://doi.org/10.1164/arrd.1965.91.1.69
20. Wallace, G. M., Winter, J. H., Winter, J. E., MacNee, W., & Best, J. J. (2009). Chest X-rays in COPD screening: Are they worthwhile? Respiratory Medicine, 103(12), 1862-1865. https://doi.org/10.1016/j.rmed.2009.07.005
21. Washko, G. R. (2010). Diagnostic imaging in COPD. Seminars in Respiratory and Critical Care Medicine, 31(3), 276-285. https://doi.org/10.1055/s-0030-1254068
22. Xie, X., de Jong, P. A., Oudkerk, M., Wang, Y., ten Hacken, N. H., Miao, J., Xu, W. H., Vliegenthart, R., de Koning, H. J., & Heuvelmans, M. A. (2012). Morphological measurements in computed tomography correlate with airflow obstruction in chronic obstructive pulmonary disease: Systematic review and meta-analysis. European Radiology, 22(10), 2085-2093. https://doi.org/10.1007/s00330-012-2480-8
23. Yamada, Y., Ueyama, M., Abe, T., Araki, T., Abe, T., Nishino, M., Jinzaki, M., Hatabu, H., & Kudoh, S. (2017). Difference in diaphragmatic motion during tidal breathing in a standing position between COPD patients and normal subjects: Time-resolved quantitative evaluation using dynamic chest radiography with flat panel detector system. European Journal of Radiology, 87, 76-82. https://doi.org/10.1016/j.ejrad.2016.12.003

