EVALUATION OF SERUM TRACE ELEMENTS (ZINC, COPPER, AND SELENIUM) IN TYPE-2 DIABETES MELLITUS
Main Article Content
Keywords
Diabetes Mellitus, Trace Elements, Zinc, selenium, Copper, Manganese, Iron, Type-2 Diabetes
Abstract
Background: Diabetes Mellitus is a metabolic disorder in which the balance of various trace elements in the body is affected. This study was done to find out the relationship between diabetes and changes in the levels of these trace elements.
Aim: To compare the levels of trace elements in patients with Type 2 Diabetes Mellitus and healthy individuals.
Materials and Methods: This cross-sectional study included 200 patients with Type 2 Diabetes Mellitus and 200 controls. It was conducted in the Clinical Biochemistry section of the Central Laboratory, Department of Biochemistry, IMCH and RC, Indore.
Results: The study showed that serum copper levels were higher and serum zinc levels were lower in patients with Type 2 Diabetes Mellitus compared to healthy controls.M,.
Conclusion: Changes in copper and zinc levels are important factors that may increase the risk of complications in people with diabetes. Based on the present study, it can be concluded that alterations in trace elements such as copper and zinc may play a role in the development and progression of Diabetes Mellitus.
References
2. Burtis, C. A., Bruns, D.E, (2016) Tietz Fundamental of Clinical Chemistry & Molecular Diagnostics: Diabetes (7thEdition). Elsevier
3. International Diabetes Federation, Atlas 2021 –10th edition, www.diabetesatlas.org
4. Kaveeshwar, S. A., & Cornwall, J. (2014). The current state of diabetes mellitus in India.The Australasian medical journal,7(1), 45–48.
5. Stanimirovic J, Radovanovic J, Banjac K, Obradovic M, Essick M, Zafirovic S, Gluvic Z, Gojobori T, Isenovic ER. Role of C-Reactive Protein in Diabetic Inflammation. Mediators Inflamm. 2022 May 17;2022:3706508.
6. Sobczak, A. I. S., Stefanowicz, F., Pitt, S. J., Ajjan, R. A., & Stewart, A. J. (2019).Total plasma magnesium, zinc, copper and selenium concentrations in type-I and type-II diabetes. BioMetals.
7. Ruíz C, Alegría A, Barberá R, Farré R, Lagarda J. Selenium, zinc and copper in plasma of patients with type 1 diabetes mellitus in different metabolic control states. J Trace Elem Med Biol. 1998 Jul;12(2):91-5.
8. Al-Maroof RA, Al-Sharbatti SS. Serum zinc levels in diabetic patients and effect of zinc supplementation on glycemic control of type 2 diabetics. Saudi Med J. 2006;27(3):344–50
9. Azab SF, Saleh SH, Elsaeed WF, Elshafie MA, Sherief LM, Esh AM. Serum trace elements in obese Egyptian children: a case-control study. Ital J Pediatr. 2014; 40:20. doi: 10.1186/1824-7288-40-20
10. Chistiakov DA, Voronova NV. Zn (2+)-transporter-8: a dual role in diabetes. Biofactors. 2009;35(4):356–63. doi: 10.1002/biof.49.
11. Dormonday TL. Trace element analysis of hair. BMJ. 1986;293:975–976.World health Organisation document. Diabetes. 2005.
12. Walter RM, Uriu-Hare JY, Olin KL, Oster MH, Anawalt BD, et al. Copper, Zinc, Manganese, and Magnesium Status and Complications of Diabetes Mellitus. Diabetes Care. 1991;14(11):1050–1056.
13. Fujimoto S. Studies on the relationship between blood trace metal concentration and the clinical status of patients with cerebrovascular disease, gastric cancer and diabetes mellitus. Hokoido Igaku Zasshi. 1987;62:913–932.
14. Salwen M. Vitamins and trace elements, McPherson: Henry’s Clinical Diagnosis and Management by Laboratory Methods. vol. 22nd edn. ; 2011,. p. 417–428.
15. Chausmer AB. Zinc, Insulin and Diabetes. J Am Coll Nutr. 1998;17(2):109–115.
16. Mamza YP, Abdullahi ZA, Gali RM, Mshelia DS, Genesis RY, Habu SA. Status of serum zinc and magnesium among type 2 diabetic subjects in Maiduguri.J Dent Med Sci.2016;15:66–70.Benakova S., Holendova B., Plecita-Hlavata L. Redox homeostasis in pancreatic beta-cells: from development to failure.Antioxidants.2021;10(4)
17. Steinbrenner H. Interference of selenium and selenoproteins with the insulin-regulated carbohydrate and lipid metabolism.Free Radic. Biol. Med.2013;65:1538–1547
