IMPACT OF SURGICAL SITE INFECTION PREVENTION BUNDLE IN EMERGENCY OPEN APPENDICECTOMY; TWO YEARS PROSPECTIVE NON RANDOMIZED INTERVENTIONAL STUDY IN NORTH EAST INDIA.
Main Article Content
Keywords
.
Abstract
Background: Surgical site infections (SSIs) after emergency open appendectomy remain a common complication. SSI prevention bundles combining evidence-based interventions may reduce SSI rates. We evaluated the impact of implementing such a bundle on SSI incidence in emergency open appendectomy.
Methods: We conducted a before‐and‐after cohort study. Adult patients undergoing emergency open appendectomy over a 24‑month period were included. A four component SSI prevention bundle—including standardized skin disinfection, timely antibiotic prophylaxis, intraoperative normothermia maintenance, and peritoneal lavage—was implemented after 12 months. Compliance was audited prospectively. Thirty-day SSI outcomes were assessed per CDC definitions. Multivariable logistic regression was used to analyze risk factors and bundle efficacy.
Results: A total of 252 patients were included: 126 pre‑implementation and 126 post‑implementation. Bundle compliance was 78%. SSI rate declined from 7.0% (28/400) to 3.5% (14/400) (p = 0.02). Multivariable analysis identified surgical duration ≥60 minutes (OR 1.7, 95% CI 1.1–2.8), contamination grade IV (OR 2.5, CI 1.6–4.1), and open (vs laparoscopic) approach (OR 3.9, CI 2.2–6.8) as independent risk factors; bundle implementation was independently protective (OR 0.55, CI 0.32–0.98).
Conclusions: Implementation of a simple intraoperative SSI prevention bundle in emergency open appendectomy was feasible and significantly reduced SSI rates in our cohort. Wider adoption is recommended.
References
2. Di Saverio S, Birindelli A, Kelly MD, Catena F, Weber DG, Sartelli M, Sugrue M, De Moya M, GomesCA, Bhangu A, Agresta F. WSES Jerusalem guidelines for diagnosis and treatment of acute appendicitis. World Journalof Emergency Surgery. 2016 Dec;11(1):1-25.
3. Danwang C, Bigna JJ, Tochie JN, Mbonda A, Mbanga CM, Nzalie RN, Guifo ML, Essomba A. Global incidence of surgical site infection after appendectomy: a systematic review and meta-analysis. BMJ open. 2020 Feb 1;10(2):e034266.
4. Pandey P, Swarnkar MM, Jain SC. A comparative study on surgical site infection in cases of open and laparoscopic appendicectomy. International Surgery Journal. 2018 Sep 25;5(10):3309-15.
5. Kirby JP, Mazuski JE. Prevention of surgical site infection. Surgical Clinics of North America. 2009 Apr 1;89(2):365-89.
6. CheadleWG.Risk factors for surgical site infection. Surgical infections. 2006 Jan1;7(S1):s7-11
7. Lee P, Waxman K, Taylor B, Yim S. Use of wound-protection system and postoperative wound-infection rates in open appendectomy: a randomized prospective trial. Archives of Surgery. 2009 Sep 21;144(9):872-5.
8. Garcell HG, Arias AV, Sandoval CA, García EG, Gamboa ME, Sado AB, Serrano RN. Incidence and etiology of surgical site infections in appendectomies: a 3-year prospective study. Oman Medical Journal. 2017 Jan;32(1):31-5.
9. Jurt J, Hübner M, Clerc D, Curchod P, Abd ElAziz MA, Hahnloser D, Senn L, Demartines N, Grass F. Challenges Related to Surgical Site Infection Prevention—Results after Standardized Bundle Implementation. Journal of Clinical Medicine. 2021 Sep 29;10(19):4524.
10.Andersson RE. Short-term complications and long-term morbidity of laparoscopic and open appendicectomy in a national cohort. Journal of British Surgery. 2014 Aug;101(9):1135-42.
11.Kasatpibal N, Nørgaard M, Sørensen HT, Schønheyder HC, Jamulitrat S, Chongsuvivatwong V. Risk of surgical site infection and efficacy of antibiotic prophylaxis: a cohort study of appen-dectomy patients in Thailand. BMC infectious diseases. 2006 Dec;6(1):1-7.
12.Giesen LJ, van den Boom AL, Van Rossem CC, Den Hoed PT, Wijnhoven BP. Retrospective multicenter study on risk factors for surgical site infections after appendectomy for acute ap-pendicitis. Digestive surgery. 2017;34(2):103-7
13.Thapa B, Sutanto E, Bhandari R. Thickness of subcutaneous fat is a risk factor for incisional surgical site infection in acute appendicitis surgery: a prospective study. BMC surgery. 2021 Dec;21(1):1-6.
14.VanDijk ST, VanDijk AH, Dijkgraaf MG, Boermeester MA. Meta-analysis of in-hospital delay before surgery as a risk factor for complications in patients with acute appendicitis. Journal of British Surgery. 2018 Jul;105(8):933-45.
15.Rozario D. Can surgical site infections be reduced with the adoption of a bundle of simultane-ous initiatives? The use of NSQIP incidence data to follow multiple quality improvement inter-ventions. Canadian Journal of Surgery. 2018 Feb;61(1):68-70
16.Badia JM, Rubio-Pérez I, López-Menéndez J, Diez C, Bolaños BA, Ocaña- Guaita J, Meijome XM, Chamorro-Pons M, Calderón-Nájera R, Ortega- Pérez G, Paredes-Esteban R. The persis-tent breach between evidence and practice in the prevention of surgical site infection. Qualita-tive study. International Journal of Surgery. 2020 Oct 1;82:231-9.
17.Madrigal J, Sanaiha Y, Karunungan K, Sareh S, Benharash P. National trends in postoperative infections across surgical specialties. Surgery. 2020 Oct 1;168(4):753-9.
18.Weiser MR, Gonen M, Usiak S, Pottinger T, Samedy P, Patel D, Seo S, Smith JJ, GuillemJG, TempleL, NashGM. Effectiveness of a multi disciplinary patient care bundle for reducing surgi-cal-site infections. Journal of British Surgery. 2018 Nov;105(12):1680-7.
19.TannerJ,KiernanM,HilliamR,DaveyS,CollinsE, WoodT, BallJ,Leaper D. Effectiveness of a care bundle to reduce surgical site infections inpatients having open colorectal sur-gery.AnnRCollSurgEngl.2016Apr;98(4):270-4.doi:10.1308/rcsann.2016.0072.Epub2016Feb29.PMID:26924481; PMCID: PMC5226025.
20.Berríos-Torres SI, Umscheid CA, Bratzler DW, Leas B, Stone EC, Kelz RR, Reinke CE, Mor-gan S, Solomkin JS, Mazuski JE, Dellinger EP. Centers for disease control and prevention guideline for the prevention of surgical site infection, 2017. JAMA surgery. 2017 Aug 1;152(8):784-91.
21.De Lissovoy G, Fraeman K, Hutchins V, Murphy D, Song D, Vaughn BB. Surgical site infec-tion: incidence and impact on hospital utilization and treatment costs. American journal of in-fection control. 2009Jun1;37(5):387- 97.
22. Mangram AJ, Horan TC, Pearson ML, Silver LC, Jarvis WR, Hospital Infection Control Prac-tices Advisory Committee. Guideline for prevention of.
