Development of Knee Osteoarthritis in Older Age Women Patients

Main Article Content

Mohammed Khalid Abbood
Hassanien Sagban Taghi
Zeyad Duraid Najmuldeen
Maysaa Ali Abdul Khaleq

Keywords

Knee joint, Osteoarthritis, Prevalence KOA, ESR, PLT, CRP.

Abstract

Background: Knee osteoarthritis is a joint disorder that shows up essentially in elderly persons and is characterized by disintegration in the articular ligament, osteophyte, synovitis inflammation, and subchondral bone firmness. Knee osteoarthritis has numerous reasons, like age, presently solidly settled as a general medical issue. It is the most impairing illness in multiple nations. Knee osteoarthritis is viewed as the more typical type of ailment in a grown-up. Old ladies are seen as increasingly influenced by this ailment. From the accessible confirmations, it is currently sensible to consider this illness as one of the most significant among the interminable non-transferable maladies and examination for the hazard factors related to this issue is substantial.
Aims: To describe the risk factors for developing symptomatic knee osteoarthritis in female Iraqi patients.
Patients and Methods: This investigation incorporates 50 female patients with clinical and radiological highlights of knee osteoarthritis in different age groups.
Result: The evaluated pervasiveness of knee osteoarthritis among women matured 40-49 years or more is 14 % of who had knee osteoarthritis with injury or trauma and 86% of women who had knee Osteoarthritis without injury or trauma. We additionally found that 94% of the ladies who experienced difficulty in doing daily schedule actions had a high increment in the levels of ESR, PLT, and CRP in serum.
Conclusion: The elevation of knee osteoarthritis prevalence in female patients is because of the fact that most female patients develop knee osteoarthritis with aging. So that the quality of life of female patients in society will decline due to multiple factors affecting those women, with some high serum levels indicators

Abstract 95 | pdf Downloads 93

References

1. Abood MK, Khaleq MAA, Sadiq AA, Hadi NR. Detection of biomarkers in serum and synovial fluid of iraqi patients with knee osteoarthritis. Int. J. Pharm. Res. 2020; 12(1): 974-978, doi: 10.31838/IJPR/2020.12.01.182.
2. Yavorskyy A, Hernandez-Santana A, McCarthy G, McMahon G. Detection of calcium phosphate crystals in the joint fluid of patients with osteoarthritis -analytical approaches and challenges. Analyst. 2008; 133(3): 302-318.
3. Yoshida M, Tsuji M, Funasaki H, Kan I, Fujii K. Analysis for the major contributor of collagenase to the primary cleavage of type II collagens in cartilage degradation. Mod. Rheumatol. 2005; 15: 180-186.
4. Zhang Q, Heng Li, Zhendong Z, Fan Y, Jiying C. Serum Metabolites as Potential Biomarkers for Diagnosis of Knee Osteoarthritis, Hindawi Publishing Corporation. 2015; Article ID: 684794: 1-7.
5. Parrish WR, Breana R. Platelet rich plasma in osteoarthritis: more than a growth factor therapy. J, Musculoskelet Regen. 2017; 3: 1518-14800.
6. Witt C, Brinkhaus B, Jena S. Acupuncture in patients with osteoarthritis of the knee: a randomised trial. J, Lancet. 2005; 366(9480): 136-43.
7. Wassilew GI, Lehnigk U, Duda GN, Taylor WR, Matziolis G, Dynybil C. The expression of proinflammatory cytokines and matrix metalloproteinase in the synovial membranes of patients with osteoarthritis compared with traumatic knee disorders. Arthroscopy. 2020; 26: 1096-1104.
8. Salve H, Gupta V, Palanivel C, Yadav K, and Singh B. Prevalence of knee osteoarthritis amongst premenopausal women in an urban
resettlement colony in south Delhi. Indian J Pub Health. 2010; 54(3):155.
9. Heesch KC, Yvette D, Brown WJ. Relationship between physical activity and stiff or painful joints in mid-aged women and older women: a 3-year prospective study. Arthritis Research & Therapy, 2007; 9: 1186-1194.
10. Zhang Y, Jordan JM. Epidemiology of osteoarthritis. Clin Geriatr Med. 2010; 26: 355-69
11. Fransen M, Bridgett L, March L, Hoy D, Penserga E, Brooks P. The epidemiology of osteoarthritis in Asia. International Journal of
Rheumatic Diseases. 2011; 14(2):113-21.
12. Riboh JC, Saltzman BM, Yanke AB, Fortier L, Cole BJ. Effect of leukocyte concentration on the efficacy of platelet-rich plasma in the treatment of knee osteoarthritis. Am J Sports Med. 2016; 44: 792-800
13. Smith LR, Trindade MC, Ikenoue T. Effects of shear stress on articular chondrocyte metabolism. Biorheology. 2000; 37: 95–107.
14. Hawamdeh ZM, Jihad M, et al. The Clinical Pattern of Knee Osteoarthritis in Jordan: A hospital Based Study. Int. J. Med. Sci. 2013;
10(6): 790-795.
15. Al-Temimi AA, Krishnan S, Kaur Sandhu A, Sajid Ali Bangash N. Medication Nonadherence: Implications for Patient Health Outcomes in Pharmacy Practice. Indonesian Journal of Pharmacy. 2021; 32(4): 416-428.