IMMUNEBOOSTING HERBS TRADITIONALLY USED IN HOUSEHOLDS
Main Article Content
Keywords
: Immune-boosting hearbs , traditionally used , fewer side effect , alternative to synthetic one .
Abstract
The mammalian immune system is vital for defending the body against infectious diseases and harmful pathogens. This paper reviews various herbs traditionally used for their immune-boosting properties. Specifically, it explores ginger, black pepper, turmeric, Tulsi , fenugreek, and ashwagandha, highlighting their active constituents and health benefits. These herbs exhibit immunomodulatory, anti-inflammatory, and antioxidant properties, making them effective in enhancing both innate and adaptive immunity. With their rich phytochemistry, they provide natural alternatives to synthetic drugs, offering holistic immune support with fewer side effects. The use of these herbs, prominent in traditional medicine systems like Ayurveda, holds promise for both preventive health and therapeutic applications. The findings emphasize the importance of incorporating these herbs into daily routines to strengthen the immune system, particularly in the face of emerging diseases.
References
. Nicholson LB. The Immune System. Essays in Biochemistry. 2016 Oct 26;60(3):275–301.
2. Ford SM. Roach’s Introductory Clinical Pharmacology. Lippincott Williams & Wilkins; 2017.
3. Marshall JS, Warrington R, Watson W, Kim HL. An Introduction to Immunology and Immunopathology. Allergy, Asthma & Clinical Immunology [Internet]. 2018 Sep;14(S2). Available from: https://aacijournal.biomedcentral.com/articles/10.1186/s13223-018-0278-1
4. Turvey SE, Broide DH. Innate Immunity. Journal of Allergy and Clinical Immunology [Internet]. 2010 Feb;125(2):S24–32. Available from: https://www.ncbi.nlm.nih.gov/pmc /articles/PMC 2832725/
5. Bonilla FA, Oettgen HC. Adaptive Immunity. Journal of Allergy and Clinical Immunology. 2010 Feb;125(2):S33–40.
6. Murphy KM, Weaver C, Mowat A, Berg L, Chaplin D, Janeway CA, et al. Janeway’s immunobiology. 9th ed. New York London Gs, Garland Science, Taylor & Francis Group; 2017.
7. Kumar D, Arya V, Kaur R, Bhat ZA, Gupta VK, Kumar V. A review of immunomodulators in the Indian traditional health care system. Journal of Microbiology, Immunology and Infection. 2012 Jun;45(3):165–84.
8. Agarwal SS, Singh VK. Immunomodulators: a review of studies on Indian medicinal plants and synthetic peptides. Part - I: Medicinal plants. 1999 Jan 1;
9. Bhattacharya SK, Bhattacharya A, Chakrabarti A. Adaptogenic activity of Siotone, a polyherbal formulation of Ayurvedic rasayanas. PubMed. 2000 Feb 1;38(2):119–28.
10. Nafiseh Shokri Mashhadi, Reza Ghiasvand, Askari G, Hariri M, Darvishi L, Mofid MR. Anti-Oxidative and Anti-Inflammatory Effects of Ginger in Health and Physical Activity: Review of Current Evidence. International Journal of Preventive Medicine [Internet]. 2013 Apr;4(Suppl 1):S36. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC3665023/
11. Rahmani AH, Al, Aly SM. Active ingredients of ginger as potential candidates in the prevention and treatment of diseases via modulation of biological activities. International Journal of Physiology, Pathophysiology and Pharmacology [Internet]. 2014 Jul 12;6(2):125. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC4106649/
12. Dugasani S, Pichika MR, Nadarajah VD, Balijepalli MK, Tandra S, Korlakunta JN. Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol. Journal of Ethnopharmacology. 2010 Feb;127(2):515–20.
13. Shukla Y, Singh M. Cancer preventive properties of ginger: A brief review. Food and Chemical Toxicology. 2007 May;45(5):683–90.
14. Nicoll R, Henein MY. Ginger (Zingiber officinale Roscoe): A hot remedy for cardiovascular disease? International Journal of Cardiology [Internet]. 2009 Jan;131(3):408–9. Available from: https://www.sciencedirect.com/science/article/pii/S0167527307016853
15. Zheng W, Wang SY. Antioxidant Activity and Phenolic Compounds in Selected Herbs. Journal of Agricultural and Food Chemistry. 2001 Nov;49(11):5165–70.
16. Ohshima H, Tatemichi M, Sawa T. Chemical basis of inflammation-induced carcinogenesis. Archives of Biochemistry and Biophysics [Internet]. 2003 Sep 1 [cited 2021 Feb 5];417(1):3–11. Available from: https://www.sciencedirect.com/science/article/abs/pii/S0003 986103002832?via%3Dihub
17.Bárta I, Smerák P, Polívková Z, Sestáková H, Langová M, Turek B, et al. Current trends and perspectives in nutrition and cancer prevention. Neoplasma [Internet]. 2006 [cited 2020 Nov 11];53(1):19–25. Available from: https://pubmed.ncbi.nlm.nih.gov/16416008/
18.Ohshima H, Tatemichi M, Sawa T. Chemical basis of inflammation-induced carcinogenesis. Archives of Biochemistry and Biophysics [Internet]. 2003 Sep 1 [cited 2021 Feb 5];417(1):3–11. Available from: https://www.sciencedirect.com/science/article/abs/pii/S00039861 03002832?via%3Dihub
19.Saleem A, Naureen I, Naeem M, Tasleem G, Ahmed H, Farooq U. Therapeutic Role of Piper nigrum L (Black Pepper) and Pharmacological Activities. Scholars International Journal of Biochemistry. 2022 Jan 27;5(1):15–21.
20.Nysanth NS, Divya S, Nair CB, Anju AB, Praveena R, Anith KN. Biological control of foot rot (Phytophthora capsici Leonian) disease in black pepper (Piper nigrum L.) with rhizospheric microorganisms. Rhizosphere. 2022 Sep;23:100578.
21.Abd El-Hack ME, El-Shall NA, El-Kasrawy NI, El-Saadony MT, Shafi ME, Zabermawi NM, et al. The use of black pepper (Piper guineense) as an ecofriendly antimicrobial agent to fight foodborne microorganisms. Environmental Science and Pollution Research. 2022 Jan 9;29(8):10894–907.
22.Zhang C, Zhao J, Famous E, Pan S, Peng X, Tian J. Antioxidant, hepatoprotective and antifungal activities of black pepper (Piper nigrum L.) essential oil. Food Chemistry. 2021 Jun;346:128845.
23.Liang J, Sun J, Chen P, Frazier J, Benefield V, Zhang M. Chemical analysis and classification of black pepper (Piper nigrum L.) based on their country of origin using mass spectrometric methods and chemometrics. Food Research International. 2021 Feb 1;140:109877–7.
24.Takooree H, Aumeeruddy MZ, Rengasamy KRR, Venugopala KN, Jeewon R, Zengin G, et al. A systematic review on black pepper (Piper nigrum L.): from folk uses to pharmacological applications. Critical Reviews in Food Science and Nutrition. 2019 Feb 11;59(sup1):S210–43.
25.Amalraj A, Haponiuk JT, Thomas S, Gopi S. Preparation, characterization and antimicrobial activity of polyvinyl alcohol/gum arabic/chitosan composite films incorporated with black pepper essential oil and ginger essential oil. International Journal of Biological Macromolecules. 2020 May;151:366–75.
26.Ali A, Wu H, Ponnampalam EN, Cottrell JJ, Dunshea FR, Suleria HAR. Comprehensive Profiling of Most Widely Used Spices for Their Phenolic Compounds through LC-ESI-QTOF-MS2 and Their Antioxidant Potential. Antioxidants. 2021 May 4;10(5):721.
27.Rasheed M, Farhana Afshan, Muhammad R, Bina Shaheen Siddiqui, Tahsin Gulzar, Mahmood A, et al. Phytochemical studies on the seed extract ofPiper nigrumLinn.. Natural Product Research. 2005 Oct 1;19(7):703–12.
28.Muhammad Asif Yousuf, Haji, Rasool F, Kashif ur Rehman, Usman F, Bilal Ahmad Ghalloo, et al. Chemical Profiling, Formulation Development, In Vitro Evaluation and Molecular Docking of Piper nigrum Seeds Extract Loaded Emulgel for Anti-Aging. 2022 Sep 14;27(18):5990–0.
29.Muhammad Asif Yousuf, Haji, Rasool F, Kashif ur Rehman, Usman F, Bilal Ahmad Ghalloo, et al. Chemical Profiling, Formulation Development, In Vitro Evaluation and Molecular Docking of Piper nigrum Seeds Extract Loaded Emulgel for Anti-Aging. 2022 Sep 14;27(18):5990–0.
30.Simon Vlad Luca, Katarzyna Gaweł-Bęben, Strzępek-Gomółka M, Czech K, Anca Trifan, Gokhan Zengin, et al. Insights into the Phytochemical and Multifunctional Biological Profile of Spices from the Genus Piper. Antioxidants. 2021 Oct 19;10(10):1642–2.
31.Lee JG, Chae Y, Shin Y, Kim YJ. Chemical composition and antioxidant capacity of black pepper pericarp. Applied Biological Chemistry. 2020 Jul 9;63(1).
32.Turrini E, Sestili P, Fimognari C. Overview of the Anticancer Potential of the “King of Spices” Piper nigrum and Its Main Constituent Piperine. Toxins. 2020 Nov 26;12(12):747.
33.Ms B, I P, Mt S, Ma R, F S, W A. Black Pepper and Health Claims: A Comprehensive Treatise [Internet]. Critical reviews in food science and nutrition. 2013. Available from: https://pubmed.ncbi.nlm.nih.gov/23768180/
34.Milenković A, Stanojević L. Black pepper: Chemical composition and biological activities. Advanced Technologies [Internet]. 2021;10(2):40–50. Available from: https://scindeks-clanci.ceon.rs/data/pdf/2406-2979/2021/2406-29792102040M.pdf
35.Barhoom AM, Abu-Naser SS. Black Pepper Expert System. Information Systems Research [Internet]. 2018 Aug 29 [cited 2024 Nov 22];2(8):9–16. Available from: https://www.researchgate.net/publication/327284997_Black_Pepper_Expert_System
36.Ahmad N, Fazal H, Abbasi BH, Farooq S, Ali M, Khan MA. Biological role of Piper nigrum L. (Black pepper): A review. Asian Pacific Journal of Tropical Biomedicine [Internet]. 2012 Jan;2(3):S1945–53. Available from: https://www.sciencedirect.com/science/article/pii/S2 221169112605243
37.Roy P, Garg AP. Enhancement of Refrigerated Shelf Life of Foods against Microbial Spoilage Using Indian Spices. European Journal of Nutrition & Food Safety [Internet]. 2023 Sep 11;15(10):38–50. Available from: https://www.researchgate.net/publication/37385 1938_Enhancement_of_Refrigerated_Shelf_Life_of_Foods_against_Microbial_Spoilage_Using_Indian_Spices
38.Bezerra DP, Farias F, Paula A, Pessoa C, de O, Silveira ER, et al. In vitro andin vivo antitumor effect of 5-FU combined with piplartine and piperine. 2008 Mar 1;28(2):156–63.
39.Stojanović-Radić Z, Pejčić M, Dimitrijević M, Aleksić A, V. Anil Kumar N, Salehi B, et al. Piperine-A Major Principle of Black Pepper: A Review of Its Bioactivity and Studies. Applied Sciences. 2019 Oct 12;9(20):4270.
40.Lee YM, Choi JH, Min WK, Han JK, Oh JW. Induction of functional erythropoietin and erythropoietin receptor gene expression by gamma-aminobutyric acid and piperine in kidney epithelial cells. Life Sciences. 2018 Dec 1;215:207–15.
41.Aswar U, Shintre S, Chepurwar S, Aswar M. Antiallergic effect of piperine on ovalbumin-induced allergic rhinitis in mice. Pharmaceutical Biology. 2015 Apr 14;53(9):1358–66.
42.Kim SH, Lee YC. Piperine inhibits eosinophil infiltration and airway hyperresponsiveness by suppressing T cell activity and Th2 cytokine production in the ovalbumin-induced asthma model. Journal of Pharmacy and Pharmacology. 2009 Mar 1;61(3):353–9.
43.Shaik AR, Y Suvarna. PHARMACOTHERAPEUTIC PROPERTIES OF BLACK PEPPER: A SYSTEMATIC REVIEW [Internet]. 2019. p. 293–304. Available from: https://www.researchgate.net/publication/338840306_PHARMACOTHERAPEUTIC_PROPERTIES_OF_BLACK_PEPPER_A_SYSTEMATIC_REVIEW
44.Neha P, Joshi MD. Piper nigrum: An overview of effects on human health. Research Journal of Science and Technology. 2020;12(4):331–7.
45.Coronella-Wood J, Terrand J, Sun H, Chen QM. c-Fos Phosphorylation Induced by H2O2 Prevents Proteasomal Degradation of c-Fos in Cardiomyocytes. Journal of Biological Chemistry. 2004 Aug;279(32):33567–74.
46.Sikora E, Bielak-Zmijewska A, Piwocka K, Janusz S, Radziszewska E. Inhibition of proliferation and apoptosis of human and rat T lymphocytes by curcumin, a curry pigment. Biochemical Pharmacology. 1997 Oct;54(8):899–907.
47.Ranjan D, Johnston TD, Wu G, Elliott L, Bondada S, Nagabhushan M. Curcumin Blocks Cyclosporine A-Resistant CD28 Costimulatory Pathway of Human T-Cell Proliferation. Journal of Surgical Research. 1998 Jul;77(2):174–8.
48.Ch. Varalakshmi, Ali A, B.V.V. Pardhasaradhi, Srivastava RM, Singh S, Ashok Khar. Immunomodulatory effects of curcumin: In-vivo. International Immunopharmacology. 2008 May 1;8(5):688–700.
49.Churchill M, Chadburn A, Bilinski RT, Bertagnolli MM. Inhibition of Intestinal Tumors by Curcumin Is Associated with Changes in the Intestinal Immune Cell Profile. Journal of Surgical Research. 2000 Apr 1;89(2):169–75.
50.Bhattacharyya S, Mandal D, Saha B, Sen GS, Das T, Sa G. Curcumin Prevents Tumor-induced T Cell Apoptosis through Stat-5a-mediated Bcl-2 Induction. Journal of Biological Chemistry. 2007 Jun;282(22):15954–64.
51.Xie L, Li XK, Naoko Funeshima-Fuji, Kimura H, Matsumoto Y, Yoshitaka Isaka, et al. Amelioration of experimental autoimmune encephalomyelitis by curcumin treatment through inhibition of IL-17 production. International immunopharmacology. 2009 May 1;9(5):575–81.
52.Moon DO, Kim MO, Choi YH, Park YM, Kim GY. Curcumin attenuates inflammatory response in IL-1β-induced human synovial fibroblasts and collagen-induced arthritis in mouse model. International Immunopharmacology [Internet]. 2010 May 1 [cited 2020 Apr 11];10(5):605–10. Available from: https://www.sciencedirect.com/science/article/pii/S1567576910000706 ?via%3Dihub
53.In Duk Jung, Jeong YI, Lee CM, Kyung Tae Noh, Soo Kyung Jeong, Sung Hak Chun, et al. COX-2 and PGE2 signaling is essential for the regulation of IDO expression by curcumin in murine bone marrow-derived dendritic cells. International immunopharmacology. 2010 Jul 1;10(7):760–8.
54.Jeong YI, Sang Hoon Kim, In Hwan Jung, Lee, Jeong Ho Chang, Lee C, et al. Curcumin Suppresses the Induction of Indoleamine 2,3-Dioxygenase by Blocking the Janus-activated Kinase-Protein Kinase Cδ-STAT1 Signaling Pathway in Interferon-γ-stimulated Murine Dendritic Cells. 2009 Feb 1;284(6):3700–8.
55.Bhaumik S, Jyothi MDivya, Khar A. Differential modulation of nitric oxide production by curcumin in host macrophages and NK cells. FEBS Letters. 2000 Oct 9;483(1):78–82.
56.Zhang HG, Kim H, Liu C, Yu S, Wang J, Grizzle WE, et al. Curcumin reverses breast tumor exosomes mediated immune suppression of NK cell tumor cytotoxicity. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2007 Jul;1773(7):1116–23.
57.Gafner S, Sang Yup Lee, Cuendet M, Barthélémy S, Laurent Vergnes, S. Labidalle, et al. Biologic evaluation of curcumin and structural derivatives in cancer chemoprevention model systems. 2004 Nov 1;65(21):2849–59.
58.Google Scholar [Internet]. Google.co.in. 2024 [cited 2024 Nov 22]. Available from: https://scholar.google.co.in/scholar?q=Chemical+constituents+and+biological+activities+of+turmeric+(Curcuma+longa+L.)&hl=en&as_sdt=0&as_vis=1&oi=scholart
59.Cc A, Ll L. Biological Activities of Curcuma Longa L [Internet]. Memorias do Instituto Oswaldo Cruz. 2001. Available from: https://pubmed.ncbi.nlm.nih.gov/11500779/
60.Banach M, Serban C, Aronow WS, Rysz J, Dragan S, Lerma EV, et al. Lipid, blood pressure and kidney update 2013. International Urology and Nephrology. 2014 Feb 27;46(5):947–61.
61.Vp M, Ar S. Antioxidant and Anti-Inflammatory Properties of Curcumin [Internet]. Advances in experimental medicine and biology. 2007. Available from: https://pubmed.ncbi.nlm .nih.gov/17569207/
62.Panahi Y, Alishiri GH, Parvin S, Sahebkar A. Mitigation of Systemic Oxidative Stress by Curcuminoids in Osteoarthritis: Results of a Randomized Controlled Trial. Journal of Dietary Supplements. 2015 Feb 17;13(2):209–20.
63.Sahebkar A. Effect of curcuminoids on oxidative stress: A systematic review and meta-analysis of randomized controlled trials. Journal of Functional Foods [Internet]. 2015 Oct 1;18:898–909. Available from: https://www.sciencedirect.com/science/article/pii/S1756464615000092
64.Priyadarsini KIndira, Maity DK, Naik GH, Kumar MSudheer, Unnikrishnan MK, Satav JG, et al. Role of phenolic O-H and methylene hydrogen on the free radical reactions and antioxidant activity of curcumin. Free Radical Biology and Medicine. 2003 Sep;35(5):475–84.
65.Js J. Anti-inflammatory Properties of Curcumin, a Major Constituent of Curcuma Longa: A Review of Preclinical and Clinical Research [Internet]. Alternative medicine review : a journal of clinical therapeutic. 2009. Available from: https://pubmed.ncbi.nlm.nih.gov/19594223/
66.M.C. Recio, I. Andujar, J.L. Rios. Anti-Inflammatory Agents from Plants: Progress and Potential. Current Medicinal Chemistry. 2012 Apr 24;19(14):2088–103.
67.Panahi Y, Hosseini MS, Khalili N, Naimi E, Simental-Mendía LE, Majeed M, et al. Effects of curcumin on serum cytokine concentrations in subjects with metabolic syndrome: A post-hoc analysis of a randomized controlled trial. Biomedicine & Pharmacotherapy. 2016 Aug;82:578–82.
68.Bast F, Rani P, Meena D. Chloroplast DNA Phylogeography of Holy Basil (Ocimum tenuiflorum) in Indian Subcontinent. The Scientific World Journal. 2014;2014:1–6.
69.Rani N, Tomar N, Upadhyaya S. Tulsi - Ocimum Sanctum: A Herbal Drug for Health Benefits. International Journal of Science and Healthcare Research. 2022 Dec 7;7(4):263–77.
70.Prasad S, Srivastava SK. Oxidative stress and cancer: Antioxidative role of Ayurvedic plants. Cancer. 2021;301–10.
71.Brar S, Sharma A. A review on medicinal herbs as immunity booster [Internet]. [cited 2024 Nov 22]. Available from: https://www.isfcppharmaspire.com/uploads/228/13795_pdf.pdf
72.Panda VS, N SR. Evaluation of cardioprotective activity of Ginkgo biloba and Ocimum sanctum in rodents. Alternative medicine review : a journal of clinical therapeutic [Internet]. 2009 Jun;14(2):161–71. Available from: https://pubmed.ncbi.nlm.nih.gov/19594225/
73.Shivananjappa M, Joshi M. Aqueous Extract ofTulsi(Ocimum sanctum) Enhances Endogenous Antioxidant Defenses of Human Hepatoma Cell Line (HepG2). Journal of Herbs, Spices & Medicinal Plants. 2012 Nov;18(4):331–48.
74.Manikandan P, Murugan RS, Abbas H, Abraham SK, Nagini S. Ocimum sanctum Linn. (Holy Basil) Ethanolic Leaf Extract Protects Against 7,12-Dimethylbenz[a]Anthracene-Induced Genotoxicity, Oxidative Stress, and Imbalance in Xenobiotic-Metabolizing Enzymes. Journal of Medicinal Food. 2007 Sep;10(3):495–502.
75.Siddique YH, Ara G, Beg T, Afzal M. Anti-genotoxic effect of Ocimum sanctum L. extract against cyproterone acetate induced genotoxic damage in cultured mammalian cells. Acta Biologica Hungarica [Internet]. 2007 Dec 1;58(4):397–409. Available from: https://pubmed.ncbi.nlm.nih .gov/18277466/
76.Jha AK, Jha M, Kaur J. Ethanolic extracts of Ocimum sanctum, Azadirachta indica and Withania somnifera cause apoptosis in SiHa cells. Research Journal of Pharmaceutical Biological and Chemical Sciences [Internet]. 2012 Apr 1;3(2):557–62. Available from: https://www.researchgate.net/publication/287480184_Ethanolic_extracts_of_Ocimum_sanctum_Azadirachta_indica_and_Withania_somnifera_cause_apoptosis_in_SiHa_cells
77.Manikandan P, Vidjaya Letchoumy P, Prathiba D, Nagini S. Combinatorial chemopreventive effect of Azadirachta indica and Ocimum sanctum on oxidant-antioxidant status, cell proliferation, apoptosis and angiogenesis in a rat forestomach carcinogenesis model. Singapore Medical Journal [Internet]. 2008 Oct 1 [cited 2024 Jun 19];49(10):814–22. Available from: https://pubmed.ncbi.nlm.nih.gov/18946617/
78.Kashyap DrSuman. Bioactive Botanicals from Basil ( Ocimum sp. ) [Internet]. Journal of Scientific & Industrial Research. 1999 [cited 2024 Nov 22]. Available from: https://www.academia.edu/94351884/Bioactive_Botanicals_from_Basil_Ocimum_sp_
79.Mediratta PK, Sharma KK, Singh S. Evaluation of immunomodulatory potential of Ocimum sanctum seed oil and its possible mechanism of action. Journal of Ethnopharmacology. 2002 Apr;80(1):15–20.
80.A.K. T, V.S. R. Immunomodulatory activity of Ocimum sanctum and its influence on cyclophosphamide induced immunosupression. [Internet]. The Indian Journal of Animal Sciences; 2008. Available from: https://www.researchgate.net/publication/ 294654881_Immunomodulatory_activity_of_Ocimum_sanctum_and_its_influence_on_cyclophosphamide_induced_immunosupression
81.Mondal S, Varma S, Bamola VD, Naik SN, Mirdha BR, Padhi MM, et al. Double-blinded randomized controlled trial for immunomodulatory effects of Tulsi (Ocimum sanctum Linn.) leaf extract on healthy volunteers. Journal of Ethnopharmacology [Internet]. 2011 Jul;136(3):452–6. Available from: https://www.sciencedirect.com/science/article/pii/S0378874111003485
82.Ali H, Dixit S. In vitro antimicrobial activity of flavanoids of Ocimum sanctum with synergistic effect of their combined form. Asian Pacific Journal of Tropical Disease. 2012 Jan;2:S396–8.
83.Singh S, Malhotra M, Majumdar DK. Antibacterial activity of Ocimum sanctum L. fixed oil. Indian Journal of Experimental Biology [Internet]. 2005 Sep 1 [cited 2022 Feb 8];43(9):835–7. Available from: https://pubmed.ncbi.nlm.nih.gov/16187537/
84.Mandal S, Mandal MD, Pal NK. Enhancing chloramphenicol and trimethoprim in vitro activity by Ocimum sanctum Linn. (Lamiaceae) leaf extract against Salmonella enterica serovar Typhi. Asian Pacific Journal of Tropical Medicine. 2012 Mar;5(3):220–4.
85.Parag S, Nilosey Vijyayshree, Rami B, Patil BR. Antibacterial Activity of Ocimum sanctum Linn. and its application in Water Purification. Research Journal of Chemistry and Environment [Internet]. 2010 Sep 1;14(3):46–50. Available from: https://www.researchgate.net/publication/ 280004308_Antibacterial_Activity_of_Ocimum_sanctum_Linn_and_its_application_in_Water_Purification
86.Taghi Naserpour Fari, Amir, Shahram Shahraki Zah, Mohammad Naderi, Sharifi B. Anti Tuberculosis Effect of Ocimum sanctum Extracts in in vitro and Macrophage Culture. Journal of Medical Sciences(Faisalabad) [Internet]. 2006 Apr 15 [cited 2024 Nov 22];6(3):348–51. Available from: https://scialert.net/fulltext/?doi=jms.2006.348.351
87.Shokeen P, Ray K, Bala M, Tandon V. Preliminary Studies on Activity of Ocimum sanctum, Drynaria quercifolia, and Annona squamosa Against Neisseria gonorrhoeae. Sexually Transmitted Diseases. 2005 Feb;32(2):106–11.
88.Sawarkar HA, Khadabadi SS, Mankar DM, Farooqui IA, Jagtap NS. Development and Biological Evaluation of Herbal Anti-Acne Gel. International Journal of PharmTech Research [Internet]. 2010 Jul 1;2(3). Available from: https://www.researchgate.net/publication/2674000 44_Development_and_Biological_Evaluation_of_Herbal_Anti-Acne_Gel
89.R Yucharoen, S Anuchapreeda, Y Tragoolpua. Anti-herpes simplex virus activity of extracts from the culinary herbs Ocimum sanctum L., Ocimum basilicum L. and Ocimum americanum L. African Journal of Biotechnology [Internet]. 2019 [cited 2024 Nov 22];10(5):860–6. Available from: https://www.ajol.info/index.php/ajb/article/view/92439
90.Suzuki A, Shirota O, Mori K, Sekita S, Fuchino H, Takano A, et al. Leishmanicidal Active Constituents from Nepalese Medicinal Plant Tulsi (Ocimum sanctum L.). Chemical and Pharmaceutical Bulletin. 2009;57(3):245–51.
91.Saini A, Sharma S, Chhibber S. Induction of resistance to respiratory tract infection with Klebsiella pneumoniae in mice fed on a diet supplemented with tulsi (Ocimum sanctum) and clove (Syzgium aromaticum) oils. Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi [Internet]. 2009 Apr;42(2):107–13. Available from: https://pubmed.ncbi.nlm.nih.gov/19597641/
92.Balakumar S, Rajan S, Thirunalasundari T, Jeeva S. Antifungal activity of Ocimum sanctum Linn. (Lamiaceae) on clinically isolated dermatophytic fungi. Asian Pacific Journal of Tropical Medicine. 2011 Aug;4(8):654–7.
93.Chandra R, Dwivedi V, Kumar Shivam, Jha AK. Detection of Antimicrobial Activity of Oscimum sanctum (Tulsi) & Trigonella foenum graecum (Methi) against some selected bacterial & fungal strains. Research Journal of Pharmaceutical Biological and Chemical Sciences [Internet]. 2011 Oct 1;2(4):809–13. Available from: https://www.researchgate.net/publication /269107198_Detection_of_Antimicrobial_Activity_of_Oscimum_sanctum_Tulsi_Trigonella_foenum_graecum_Methi_against_some_selected_bacterial_fungal_strains
94.A.J. Rajamma, Dubey S, S.B. Sateesha, Tiwari SN, Ghosh SK. Comparative larvicidal activity of different species ofOcimumagainstCulex Quinquefasciatus. Natural Product Research. 2011 Dec 1;25(20):1916–22.
95.Inbaneson SJ, Sundaram R, Suganthi P. In vitro antiplasmodial effect of ethanolic extracts of traditional medicinal plant Ocimum species against Plasmodium falciparum. Asian Pacific Journal of Tropical Medicine. 2012 Feb;5(2):103–6.
96.Petropoulos G. Fenugreek [Internet]. Google Books. 2024 [cited 2024 Nov 22]. Available from: https://books.google.co.in/books?hl=en&lr=&id=BKalSd5bInAC&oi=fnd&pg=PP1&dq=The+genus+Trigonella.+GA
97.A. Mehrafarin, A. Qaderi, Sh. Rezazadeh, H. Naghdi Badi, Zand E. Bioengineering of Important Secondary Metabolites and Metabolic Pathways in Fenugreek (Trigonella foenum-graecum L.). Journal of Medicinal Plants [Internet]. 2010 Sep 1;9(35):1–18. Available from: https://www.researchgate.net/publication/279541625_Bioengineering_of_Important_Secondary_Metabolites_and_Metabolic_Pathways_in_Fenugreek_Trigonella_foenum-graecum_L
98.Wani SA, Kumar P. Fenugreek: A review on its nutraceutical properties and utilization in various food products. Journal of the Saudi Society of Agricultural Sciences. 2018 Apr;17(2):97–106.
99.Meghwal M. A Review on the Functional Properties, Nutritional Content, Medicinal Utilization and Potential Application of Fenugreek. Journal of Food Processing & Technology. 2012;03(09).
100.Singh N, Bhalla M, De Jager P, Gilca M. An Overview on Ashwagandha: A Rasayana (Rejuvenator) of Ayurveda. African Journal of Traditional, Complementary and Alternative Medicines [Internet]. 2011 Jul 15;8(5S). Available from: https://www.ncbi.nlm.nih.gov/pmc/ articles/PMC3252722/
101.Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. Alternative Medicine Review: A Journal of Clinical Therapeutic [Internet]. 2000 Aug 1;5(4):334–46. Available from: https://pubmed.ncbi.nlm.nih.gov /10956379/
102.Kaushik MK, Kaul SC, Wadhwa R, Yanagisawa M, Urade Y. Triethylene glycol, an active component of Ashwagandha (Withania somnifera) leaves, is responsible for sleep induction. Lakshmana MK, editor. PLOS ONE. 2017 Feb 16;12(2):e0172508.
103.Kaur P, Robin, Makanjuola VO, Arora R, Singh B, Arora S. Immunopotentiating significance of conventionally used plant adaptogens as modulators in biochemical and molecular signalling pathways in cell mediated processes. Biomedicine & Pharmacotherapy. 2017 Nov 1;95:1815–29.
104.Mikulska P, Malinowska M, Ignacyk M, Szustowski P, Nowak J, Pesta K, et al. Ashwagandha (Withania somnifera)—Current Research on the Health-Promoting Activities: A Narrative Review. Pharmaceutics [Internet]. 2023 Mar 24;15(4):1057. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10147008/
105.Lopresti AL, Drummond PD, Smith SJ. A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagandha (Withania somnifera) in Aging, Overweight Males. American Journal of Men’s Health [Internet]. 2019 Mar;13(2):155798831983598. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles /PMC6438434/
106.Morales-Brown P. Ashwagandha: Health benefits, side effects, and how to use [Internet]. www.medicalnewstoday.com. 2020. Available from: https://www.medicalnews today.com/articles/318407
107.Xing D, Yoo C, Gonzalez D, Jenkins V, Nottingham K, Dickerson B, et al. Effects of Acute Ashwagandha Ingestion on Cognitive Function. International Journal of Environmental Research and Public Health. 2022 Sep 20;19(19):11852.
108.Lopresti AL, Smith SJ. Ashwagandha (Withania somnifera) for the treatment and enhancement of mental and physical conditions: A systematic review of human trials. Journal of Herbal Medicine. 2021 Aug;28:100434.
2. Ford SM. Roach’s Introductory Clinical Pharmacology. Lippincott Williams & Wilkins; 2017.
3. Marshall JS, Warrington R, Watson W, Kim HL. An Introduction to Immunology and Immunopathology. Allergy, Asthma & Clinical Immunology [Internet]. 2018 Sep;14(S2). Available from: https://aacijournal.biomedcentral.com/articles/10.1186/s13223-018-0278-1
4. Turvey SE, Broide DH. Innate Immunity. Journal of Allergy and Clinical Immunology [Internet]. 2010 Feb;125(2):S24–32. Available from: https://www.ncbi.nlm.nih.gov/pmc /articles/PMC 2832725/
5. Bonilla FA, Oettgen HC. Adaptive Immunity. Journal of Allergy and Clinical Immunology. 2010 Feb;125(2):S33–40.
6. Murphy KM, Weaver C, Mowat A, Berg L, Chaplin D, Janeway CA, et al. Janeway’s immunobiology. 9th ed. New York London Gs, Garland Science, Taylor & Francis Group; 2017.
7. Kumar D, Arya V, Kaur R, Bhat ZA, Gupta VK, Kumar V. A review of immunomodulators in the Indian traditional health care system. Journal of Microbiology, Immunology and Infection. 2012 Jun;45(3):165–84.
8. Agarwal SS, Singh VK. Immunomodulators: a review of studies on Indian medicinal plants and synthetic peptides. Part - I: Medicinal plants. 1999 Jan 1;
9. Bhattacharya SK, Bhattacharya A, Chakrabarti A. Adaptogenic activity of Siotone, a polyherbal formulation of Ayurvedic rasayanas. PubMed. 2000 Feb 1;38(2):119–28.
10. Nafiseh Shokri Mashhadi, Reza Ghiasvand, Askari G, Hariri M, Darvishi L, Mofid MR. Anti-Oxidative and Anti-Inflammatory Effects of Ginger in Health and Physical Activity: Review of Current Evidence. International Journal of Preventive Medicine [Internet]. 2013 Apr;4(Suppl 1):S36. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC3665023/
11. Rahmani AH, Al, Aly SM. Active ingredients of ginger as potential candidates in the prevention and treatment of diseases via modulation of biological activities. International Journal of Physiology, Pathophysiology and Pharmacology [Internet]. 2014 Jul 12;6(2):125. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC4106649/
12. Dugasani S, Pichika MR, Nadarajah VD, Balijepalli MK, Tandra S, Korlakunta JN. Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol. Journal of Ethnopharmacology. 2010 Feb;127(2):515–20.
13. Shukla Y, Singh M. Cancer preventive properties of ginger: A brief review. Food and Chemical Toxicology. 2007 May;45(5):683–90.
14. Nicoll R, Henein MY. Ginger (Zingiber officinale Roscoe): A hot remedy for cardiovascular disease? International Journal of Cardiology [Internet]. 2009 Jan;131(3):408–9. Available from: https://www.sciencedirect.com/science/article/pii/S0167527307016853
15. Zheng W, Wang SY. Antioxidant Activity and Phenolic Compounds in Selected Herbs. Journal of Agricultural and Food Chemistry. 2001 Nov;49(11):5165–70.
16. Ohshima H, Tatemichi M, Sawa T. Chemical basis of inflammation-induced carcinogenesis. Archives of Biochemistry and Biophysics [Internet]. 2003 Sep 1 [cited 2021 Feb 5];417(1):3–11. Available from: https://www.sciencedirect.com/science/article/abs/pii/S0003 986103002832?via%3Dihub
17.Bárta I, Smerák P, Polívková Z, Sestáková H, Langová M, Turek B, et al. Current trends and perspectives in nutrition and cancer prevention. Neoplasma [Internet]. 2006 [cited 2020 Nov 11];53(1):19–25. Available from: https://pubmed.ncbi.nlm.nih.gov/16416008/
18.Ohshima H, Tatemichi M, Sawa T. Chemical basis of inflammation-induced carcinogenesis. Archives of Biochemistry and Biophysics [Internet]. 2003 Sep 1 [cited 2021 Feb 5];417(1):3–11. Available from: https://www.sciencedirect.com/science/article/abs/pii/S00039861 03002832?via%3Dihub
19.Saleem A, Naureen I, Naeem M, Tasleem G, Ahmed H, Farooq U. Therapeutic Role of Piper nigrum L (Black Pepper) and Pharmacological Activities. Scholars International Journal of Biochemistry. 2022 Jan 27;5(1):15–21.
20.Nysanth NS, Divya S, Nair CB, Anju AB, Praveena R, Anith KN. Biological control of foot rot (Phytophthora capsici Leonian) disease in black pepper (Piper nigrum L.) with rhizospheric microorganisms. Rhizosphere. 2022 Sep;23:100578.
21.Abd El-Hack ME, El-Shall NA, El-Kasrawy NI, El-Saadony MT, Shafi ME, Zabermawi NM, et al. The use of black pepper (Piper guineense) as an ecofriendly antimicrobial agent to fight foodborne microorganisms. Environmental Science and Pollution Research. 2022 Jan 9;29(8):10894–907.
22.Zhang C, Zhao J, Famous E, Pan S, Peng X, Tian J. Antioxidant, hepatoprotective and antifungal activities of black pepper (Piper nigrum L.) essential oil. Food Chemistry. 2021 Jun;346:128845.
23.Liang J, Sun J, Chen P, Frazier J, Benefield V, Zhang M. Chemical analysis and classification of black pepper (Piper nigrum L.) based on their country of origin using mass spectrometric methods and chemometrics. Food Research International. 2021 Feb 1;140:109877–7.
24.Takooree H, Aumeeruddy MZ, Rengasamy KRR, Venugopala KN, Jeewon R, Zengin G, et al. A systematic review on black pepper (Piper nigrum L.): from folk uses to pharmacological applications. Critical Reviews in Food Science and Nutrition. 2019 Feb 11;59(sup1):S210–43.
25.Amalraj A, Haponiuk JT, Thomas S, Gopi S. Preparation, characterization and antimicrobial activity of polyvinyl alcohol/gum arabic/chitosan composite films incorporated with black pepper essential oil and ginger essential oil. International Journal of Biological Macromolecules. 2020 May;151:366–75.
26.Ali A, Wu H, Ponnampalam EN, Cottrell JJ, Dunshea FR, Suleria HAR. Comprehensive Profiling of Most Widely Used Spices for Their Phenolic Compounds through LC-ESI-QTOF-MS2 and Their Antioxidant Potential. Antioxidants. 2021 May 4;10(5):721.
27.Rasheed M, Farhana Afshan, Muhammad R, Bina Shaheen Siddiqui, Tahsin Gulzar, Mahmood A, et al. Phytochemical studies on the seed extract ofPiper nigrumLinn.. Natural Product Research. 2005 Oct 1;19(7):703–12.
28.Muhammad Asif Yousuf, Haji, Rasool F, Kashif ur Rehman, Usman F, Bilal Ahmad Ghalloo, et al. Chemical Profiling, Formulation Development, In Vitro Evaluation and Molecular Docking of Piper nigrum Seeds Extract Loaded Emulgel for Anti-Aging. 2022 Sep 14;27(18):5990–0.
29.Muhammad Asif Yousuf, Haji, Rasool F, Kashif ur Rehman, Usman F, Bilal Ahmad Ghalloo, et al. Chemical Profiling, Formulation Development, In Vitro Evaluation and Molecular Docking of Piper nigrum Seeds Extract Loaded Emulgel for Anti-Aging. 2022 Sep 14;27(18):5990–0.
30.Simon Vlad Luca, Katarzyna Gaweł-Bęben, Strzępek-Gomółka M, Czech K, Anca Trifan, Gokhan Zengin, et al. Insights into the Phytochemical and Multifunctional Biological Profile of Spices from the Genus Piper. Antioxidants. 2021 Oct 19;10(10):1642–2.
31.Lee JG, Chae Y, Shin Y, Kim YJ. Chemical composition and antioxidant capacity of black pepper pericarp. Applied Biological Chemistry. 2020 Jul 9;63(1).
32.Turrini E, Sestili P, Fimognari C. Overview of the Anticancer Potential of the “King of Spices” Piper nigrum and Its Main Constituent Piperine. Toxins. 2020 Nov 26;12(12):747.
33.Ms B, I P, Mt S, Ma R, F S, W A. Black Pepper and Health Claims: A Comprehensive Treatise [Internet]. Critical reviews in food science and nutrition. 2013. Available from: https://pubmed.ncbi.nlm.nih.gov/23768180/
34.Milenković A, Stanojević L. Black pepper: Chemical composition and biological activities. Advanced Technologies [Internet]. 2021;10(2):40–50. Available from: https://scindeks-clanci.ceon.rs/data/pdf/2406-2979/2021/2406-29792102040M.pdf
35.Barhoom AM, Abu-Naser SS. Black Pepper Expert System. Information Systems Research [Internet]. 2018 Aug 29 [cited 2024 Nov 22];2(8):9–16. Available from: https://www.researchgate.net/publication/327284997_Black_Pepper_Expert_System
36.Ahmad N, Fazal H, Abbasi BH, Farooq S, Ali M, Khan MA. Biological role of Piper nigrum L. (Black pepper): A review. Asian Pacific Journal of Tropical Biomedicine [Internet]. 2012 Jan;2(3):S1945–53. Available from: https://www.sciencedirect.com/science/article/pii/S2 221169112605243
37.Roy P, Garg AP. Enhancement of Refrigerated Shelf Life of Foods against Microbial Spoilage Using Indian Spices. European Journal of Nutrition & Food Safety [Internet]. 2023 Sep 11;15(10):38–50. Available from: https://www.researchgate.net/publication/37385 1938_Enhancement_of_Refrigerated_Shelf_Life_of_Foods_against_Microbial_Spoilage_Using_Indian_Spices
38.Bezerra DP, Farias F, Paula A, Pessoa C, de O, Silveira ER, et al. In vitro andin vivo antitumor effect of 5-FU combined with piplartine and piperine. 2008 Mar 1;28(2):156–63.
39.Stojanović-Radić Z, Pejčić M, Dimitrijević M, Aleksić A, V. Anil Kumar N, Salehi B, et al. Piperine-A Major Principle of Black Pepper: A Review of Its Bioactivity and Studies. Applied Sciences. 2019 Oct 12;9(20):4270.
40.Lee YM, Choi JH, Min WK, Han JK, Oh JW. Induction of functional erythropoietin and erythropoietin receptor gene expression by gamma-aminobutyric acid and piperine in kidney epithelial cells. Life Sciences. 2018 Dec 1;215:207–15.
41.Aswar U, Shintre S, Chepurwar S, Aswar M. Antiallergic effect of piperine on ovalbumin-induced allergic rhinitis in mice. Pharmaceutical Biology. 2015 Apr 14;53(9):1358–66.
42.Kim SH, Lee YC. Piperine inhibits eosinophil infiltration and airway hyperresponsiveness by suppressing T cell activity and Th2 cytokine production in the ovalbumin-induced asthma model. Journal of Pharmacy and Pharmacology. 2009 Mar 1;61(3):353–9.
43.Shaik AR, Y Suvarna. PHARMACOTHERAPEUTIC PROPERTIES OF BLACK PEPPER: A SYSTEMATIC REVIEW [Internet]. 2019. p. 293–304. Available from: https://www.researchgate.net/publication/338840306_PHARMACOTHERAPEUTIC_PROPERTIES_OF_BLACK_PEPPER_A_SYSTEMATIC_REVIEW
44.Neha P, Joshi MD. Piper nigrum: An overview of effects on human health. Research Journal of Science and Technology. 2020;12(4):331–7.
45.Coronella-Wood J, Terrand J, Sun H, Chen QM. c-Fos Phosphorylation Induced by H2O2 Prevents Proteasomal Degradation of c-Fos in Cardiomyocytes. Journal of Biological Chemistry. 2004 Aug;279(32):33567–74.
46.Sikora E, Bielak-Zmijewska A, Piwocka K, Janusz S, Radziszewska E. Inhibition of proliferation and apoptosis of human and rat T lymphocytes by curcumin, a curry pigment. Biochemical Pharmacology. 1997 Oct;54(8):899–907.
47.Ranjan D, Johnston TD, Wu G, Elliott L, Bondada S, Nagabhushan M. Curcumin Blocks Cyclosporine A-Resistant CD28 Costimulatory Pathway of Human T-Cell Proliferation. Journal of Surgical Research. 1998 Jul;77(2):174–8.
48.Ch. Varalakshmi, Ali A, B.V.V. Pardhasaradhi, Srivastava RM, Singh S, Ashok Khar. Immunomodulatory effects of curcumin: In-vivo. International Immunopharmacology. 2008 May 1;8(5):688–700.
49.Churchill M, Chadburn A, Bilinski RT, Bertagnolli MM. Inhibition of Intestinal Tumors by Curcumin Is Associated with Changes in the Intestinal Immune Cell Profile. Journal of Surgical Research. 2000 Apr 1;89(2):169–75.
50.Bhattacharyya S, Mandal D, Saha B, Sen GS, Das T, Sa G. Curcumin Prevents Tumor-induced T Cell Apoptosis through Stat-5a-mediated Bcl-2 Induction. Journal of Biological Chemistry. 2007 Jun;282(22):15954–64.
51.Xie L, Li XK, Naoko Funeshima-Fuji, Kimura H, Matsumoto Y, Yoshitaka Isaka, et al. Amelioration of experimental autoimmune encephalomyelitis by curcumin treatment through inhibition of IL-17 production. International immunopharmacology. 2009 May 1;9(5):575–81.
52.Moon DO, Kim MO, Choi YH, Park YM, Kim GY. Curcumin attenuates inflammatory response in IL-1β-induced human synovial fibroblasts and collagen-induced arthritis in mouse model. International Immunopharmacology [Internet]. 2010 May 1 [cited 2020 Apr 11];10(5):605–10. Available from: https://www.sciencedirect.com/science/article/pii/S1567576910000706 ?via%3Dihub
53.In Duk Jung, Jeong YI, Lee CM, Kyung Tae Noh, Soo Kyung Jeong, Sung Hak Chun, et al. COX-2 and PGE2 signaling is essential for the regulation of IDO expression by curcumin in murine bone marrow-derived dendritic cells. International immunopharmacology. 2010 Jul 1;10(7):760–8.
54.Jeong YI, Sang Hoon Kim, In Hwan Jung, Lee, Jeong Ho Chang, Lee C, et al. Curcumin Suppresses the Induction of Indoleamine 2,3-Dioxygenase by Blocking the Janus-activated Kinase-Protein Kinase Cδ-STAT1 Signaling Pathway in Interferon-γ-stimulated Murine Dendritic Cells. 2009 Feb 1;284(6):3700–8.
55.Bhaumik S, Jyothi MDivya, Khar A. Differential modulation of nitric oxide production by curcumin in host macrophages and NK cells. FEBS Letters. 2000 Oct 9;483(1):78–82.
56.Zhang HG, Kim H, Liu C, Yu S, Wang J, Grizzle WE, et al. Curcumin reverses breast tumor exosomes mediated immune suppression of NK cell tumor cytotoxicity. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2007 Jul;1773(7):1116–23.
57.Gafner S, Sang Yup Lee, Cuendet M, Barthélémy S, Laurent Vergnes, S. Labidalle, et al. Biologic evaluation of curcumin and structural derivatives in cancer chemoprevention model systems. 2004 Nov 1;65(21):2849–59.
58.Google Scholar [Internet]. Google.co.in. 2024 [cited 2024 Nov 22]. Available from: https://scholar.google.co.in/scholar?q=Chemical+constituents+and+biological+activities+of+turmeric+(Curcuma+longa+L.)&hl=en&as_sdt=0&as_vis=1&oi=scholart
59.Cc A, Ll L. Biological Activities of Curcuma Longa L [Internet]. Memorias do Instituto Oswaldo Cruz. 2001. Available from: https://pubmed.ncbi.nlm.nih.gov/11500779/
60.Banach M, Serban C, Aronow WS, Rysz J, Dragan S, Lerma EV, et al. Lipid, blood pressure and kidney update 2013. International Urology and Nephrology. 2014 Feb 27;46(5):947–61.
61.Vp M, Ar S. Antioxidant and Anti-Inflammatory Properties of Curcumin [Internet]. Advances in experimental medicine and biology. 2007. Available from: https://pubmed.ncbi.nlm .nih.gov/17569207/
62.Panahi Y, Alishiri GH, Parvin S, Sahebkar A. Mitigation of Systemic Oxidative Stress by Curcuminoids in Osteoarthritis: Results of a Randomized Controlled Trial. Journal of Dietary Supplements. 2015 Feb 17;13(2):209–20.
63.Sahebkar A. Effect of curcuminoids on oxidative stress: A systematic review and meta-analysis of randomized controlled trials. Journal of Functional Foods [Internet]. 2015 Oct 1;18:898–909. Available from: https://www.sciencedirect.com/science/article/pii/S1756464615000092
64.Priyadarsini KIndira, Maity DK, Naik GH, Kumar MSudheer, Unnikrishnan MK, Satav JG, et al. Role of phenolic O-H and methylene hydrogen on the free radical reactions and antioxidant activity of curcumin. Free Radical Biology and Medicine. 2003 Sep;35(5):475–84.
65.Js J. Anti-inflammatory Properties of Curcumin, a Major Constituent of Curcuma Longa: A Review of Preclinical and Clinical Research [Internet]. Alternative medicine review : a journal of clinical therapeutic. 2009. Available from: https://pubmed.ncbi.nlm.nih.gov/19594223/
66.M.C. Recio, I. Andujar, J.L. Rios. Anti-Inflammatory Agents from Plants: Progress and Potential. Current Medicinal Chemistry. 2012 Apr 24;19(14):2088–103.
67.Panahi Y, Hosseini MS, Khalili N, Naimi E, Simental-Mendía LE, Majeed M, et al. Effects of curcumin on serum cytokine concentrations in subjects with metabolic syndrome: A post-hoc analysis of a randomized controlled trial. Biomedicine & Pharmacotherapy. 2016 Aug;82:578–82.
68.Bast F, Rani P, Meena D. Chloroplast DNA Phylogeography of Holy Basil (Ocimum tenuiflorum) in Indian Subcontinent. The Scientific World Journal. 2014;2014:1–6.
69.Rani N, Tomar N, Upadhyaya S. Tulsi - Ocimum Sanctum: A Herbal Drug for Health Benefits. International Journal of Science and Healthcare Research. 2022 Dec 7;7(4):263–77.
70.Prasad S, Srivastava SK. Oxidative stress and cancer: Antioxidative role of Ayurvedic plants. Cancer. 2021;301–10.
71.Brar S, Sharma A. A review on medicinal herbs as immunity booster [Internet]. [cited 2024 Nov 22]. Available from: https://www.isfcppharmaspire.com/uploads/228/13795_pdf.pdf
72.Panda VS, N SR. Evaluation of cardioprotective activity of Ginkgo biloba and Ocimum sanctum in rodents. Alternative medicine review : a journal of clinical therapeutic [Internet]. 2009 Jun;14(2):161–71. Available from: https://pubmed.ncbi.nlm.nih.gov/19594225/
73.Shivananjappa M, Joshi M. Aqueous Extract ofTulsi(Ocimum sanctum) Enhances Endogenous Antioxidant Defenses of Human Hepatoma Cell Line (HepG2). Journal of Herbs, Spices & Medicinal Plants. 2012 Nov;18(4):331–48.
74.Manikandan P, Murugan RS, Abbas H, Abraham SK, Nagini S. Ocimum sanctum Linn. (Holy Basil) Ethanolic Leaf Extract Protects Against 7,12-Dimethylbenz[a]Anthracene-Induced Genotoxicity, Oxidative Stress, and Imbalance in Xenobiotic-Metabolizing Enzymes. Journal of Medicinal Food. 2007 Sep;10(3):495–502.
75.Siddique YH, Ara G, Beg T, Afzal M. Anti-genotoxic effect of Ocimum sanctum L. extract against cyproterone acetate induced genotoxic damage in cultured mammalian cells. Acta Biologica Hungarica [Internet]. 2007 Dec 1;58(4):397–409. Available from: https://pubmed.ncbi.nlm.nih .gov/18277466/
76.Jha AK, Jha M, Kaur J. Ethanolic extracts of Ocimum sanctum, Azadirachta indica and Withania somnifera cause apoptosis in SiHa cells. Research Journal of Pharmaceutical Biological and Chemical Sciences [Internet]. 2012 Apr 1;3(2):557–62. Available from: https://www.researchgate.net/publication/287480184_Ethanolic_extracts_of_Ocimum_sanctum_Azadirachta_indica_and_Withania_somnifera_cause_apoptosis_in_SiHa_cells
77.Manikandan P, Vidjaya Letchoumy P, Prathiba D, Nagini S. Combinatorial chemopreventive effect of Azadirachta indica and Ocimum sanctum on oxidant-antioxidant status, cell proliferation, apoptosis and angiogenesis in a rat forestomach carcinogenesis model. Singapore Medical Journal [Internet]. 2008 Oct 1 [cited 2024 Jun 19];49(10):814–22. Available from: https://pubmed.ncbi.nlm.nih.gov/18946617/
78.Kashyap DrSuman. Bioactive Botanicals from Basil ( Ocimum sp. ) [Internet]. Journal of Scientific & Industrial Research. 1999 [cited 2024 Nov 22]. Available from: https://www.academia.edu/94351884/Bioactive_Botanicals_from_Basil_Ocimum_sp_
79.Mediratta PK, Sharma KK, Singh S. Evaluation of immunomodulatory potential of Ocimum sanctum seed oil and its possible mechanism of action. Journal of Ethnopharmacology. 2002 Apr;80(1):15–20.
80.A.K. T, V.S. R. Immunomodulatory activity of Ocimum sanctum and its influence on cyclophosphamide induced immunosupression. [Internet]. The Indian Journal of Animal Sciences; 2008. Available from: https://www.researchgate.net/publication/ 294654881_Immunomodulatory_activity_of_Ocimum_sanctum_and_its_influence_on_cyclophosphamide_induced_immunosupression
81.Mondal S, Varma S, Bamola VD, Naik SN, Mirdha BR, Padhi MM, et al. Double-blinded randomized controlled trial for immunomodulatory effects of Tulsi (Ocimum sanctum Linn.) leaf extract on healthy volunteers. Journal of Ethnopharmacology [Internet]. 2011 Jul;136(3):452–6. Available from: https://www.sciencedirect.com/science/article/pii/S0378874111003485
82.Ali H, Dixit S. In vitro antimicrobial activity of flavanoids of Ocimum sanctum with synergistic effect of their combined form. Asian Pacific Journal of Tropical Disease. 2012 Jan;2:S396–8.
83.Singh S, Malhotra M, Majumdar DK. Antibacterial activity of Ocimum sanctum L. fixed oil. Indian Journal of Experimental Biology [Internet]. 2005 Sep 1 [cited 2022 Feb 8];43(9):835–7. Available from: https://pubmed.ncbi.nlm.nih.gov/16187537/
84.Mandal S, Mandal MD, Pal NK. Enhancing chloramphenicol and trimethoprim in vitro activity by Ocimum sanctum Linn. (Lamiaceae) leaf extract against Salmonella enterica serovar Typhi. Asian Pacific Journal of Tropical Medicine. 2012 Mar;5(3):220–4.
85.Parag S, Nilosey Vijyayshree, Rami B, Patil BR. Antibacterial Activity of Ocimum sanctum Linn. and its application in Water Purification. Research Journal of Chemistry and Environment [Internet]. 2010 Sep 1;14(3):46–50. Available from: https://www.researchgate.net/publication/ 280004308_Antibacterial_Activity_of_Ocimum_sanctum_Linn_and_its_application_in_Water_Purification
86.Taghi Naserpour Fari, Amir, Shahram Shahraki Zah, Mohammad Naderi, Sharifi B. Anti Tuberculosis Effect of Ocimum sanctum Extracts in in vitro and Macrophage Culture. Journal of Medical Sciences(Faisalabad) [Internet]. 2006 Apr 15 [cited 2024 Nov 22];6(3):348–51. Available from: https://scialert.net/fulltext/?doi=jms.2006.348.351
87.Shokeen P, Ray K, Bala M, Tandon V. Preliminary Studies on Activity of Ocimum sanctum, Drynaria quercifolia, and Annona squamosa Against Neisseria gonorrhoeae. Sexually Transmitted Diseases. 2005 Feb;32(2):106–11.
88.Sawarkar HA, Khadabadi SS, Mankar DM, Farooqui IA, Jagtap NS. Development and Biological Evaluation of Herbal Anti-Acne Gel. International Journal of PharmTech Research [Internet]. 2010 Jul 1;2(3). Available from: https://www.researchgate.net/publication/2674000 44_Development_and_Biological_Evaluation_of_Herbal_Anti-Acne_Gel
89.R Yucharoen, S Anuchapreeda, Y Tragoolpua. Anti-herpes simplex virus activity of extracts from the culinary herbs Ocimum sanctum L., Ocimum basilicum L. and Ocimum americanum L. African Journal of Biotechnology [Internet]. 2019 [cited 2024 Nov 22];10(5):860–6. Available from: https://www.ajol.info/index.php/ajb/article/view/92439
90.Suzuki A, Shirota O, Mori K, Sekita S, Fuchino H, Takano A, et al. Leishmanicidal Active Constituents from Nepalese Medicinal Plant Tulsi (Ocimum sanctum L.). Chemical and Pharmaceutical Bulletin. 2009;57(3):245–51.
91.Saini A, Sharma S, Chhibber S. Induction of resistance to respiratory tract infection with Klebsiella pneumoniae in mice fed on a diet supplemented with tulsi (Ocimum sanctum) and clove (Syzgium aromaticum) oils. Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi [Internet]. 2009 Apr;42(2):107–13. Available from: https://pubmed.ncbi.nlm.nih.gov/19597641/
92.Balakumar S, Rajan S, Thirunalasundari T, Jeeva S. Antifungal activity of Ocimum sanctum Linn. (Lamiaceae) on clinically isolated dermatophytic fungi. Asian Pacific Journal of Tropical Medicine. 2011 Aug;4(8):654–7.
93.Chandra R, Dwivedi V, Kumar Shivam, Jha AK. Detection of Antimicrobial Activity of Oscimum sanctum (Tulsi) & Trigonella foenum graecum (Methi) against some selected bacterial & fungal strains. Research Journal of Pharmaceutical Biological and Chemical Sciences [Internet]. 2011 Oct 1;2(4):809–13. Available from: https://www.researchgate.net/publication /269107198_Detection_of_Antimicrobial_Activity_of_Oscimum_sanctum_Tulsi_Trigonella_foenum_graecum_Methi_against_some_selected_bacterial_fungal_strains
94.A.J. Rajamma, Dubey S, S.B. Sateesha, Tiwari SN, Ghosh SK. Comparative larvicidal activity of different species ofOcimumagainstCulex Quinquefasciatus. Natural Product Research. 2011 Dec 1;25(20):1916–22.
95.Inbaneson SJ, Sundaram R, Suganthi P. In vitro antiplasmodial effect of ethanolic extracts of traditional medicinal plant Ocimum species against Plasmodium falciparum. Asian Pacific Journal of Tropical Medicine. 2012 Feb;5(2):103–6.
96.Petropoulos G. Fenugreek [Internet]. Google Books. 2024 [cited 2024 Nov 22]. Available from: https://books.google.co.in/books?hl=en&lr=&id=BKalSd5bInAC&oi=fnd&pg=PP1&dq=The+genus+Trigonella.+GA
97.A. Mehrafarin, A. Qaderi, Sh. Rezazadeh, H. Naghdi Badi, Zand E. Bioengineering of Important Secondary Metabolites and Metabolic Pathways in Fenugreek (Trigonella foenum-graecum L.). Journal of Medicinal Plants [Internet]. 2010 Sep 1;9(35):1–18. Available from: https://www.researchgate.net/publication/279541625_Bioengineering_of_Important_Secondary_Metabolites_and_Metabolic_Pathways_in_Fenugreek_Trigonella_foenum-graecum_L
98.Wani SA, Kumar P. Fenugreek: A review on its nutraceutical properties and utilization in various food products. Journal of the Saudi Society of Agricultural Sciences. 2018 Apr;17(2):97–106.
99.Meghwal M. A Review on the Functional Properties, Nutritional Content, Medicinal Utilization and Potential Application of Fenugreek. Journal of Food Processing & Technology. 2012;03(09).
100.Singh N, Bhalla M, De Jager P, Gilca M. An Overview on Ashwagandha: A Rasayana (Rejuvenator) of Ayurveda. African Journal of Traditional, Complementary and Alternative Medicines [Internet]. 2011 Jul 15;8(5S). Available from: https://www.ncbi.nlm.nih.gov/pmc/ articles/PMC3252722/
101.Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. Alternative Medicine Review: A Journal of Clinical Therapeutic [Internet]. 2000 Aug 1;5(4):334–46. Available from: https://pubmed.ncbi.nlm.nih.gov /10956379/
102.Kaushik MK, Kaul SC, Wadhwa R, Yanagisawa M, Urade Y. Triethylene glycol, an active component of Ashwagandha (Withania somnifera) leaves, is responsible for sleep induction. Lakshmana MK, editor. PLOS ONE. 2017 Feb 16;12(2):e0172508.
103.Kaur P, Robin, Makanjuola VO, Arora R, Singh B, Arora S. Immunopotentiating significance of conventionally used plant adaptogens as modulators in biochemical and molecular signalling pathways in cell mediated processes. Biomedicine & Pharmacotherapy. 2017 Nov 1;95:1815–29.
104.Mikulska P, Malinowska M, Ignacyk M, Szustowski P, Nowak J, Pesta K, et al. Ashwagandha (Withania somnifera)—Current Research on the Health-Promoting Activities: A Narrative Review. Pharmaceutics [Internet]. 2023 Mar 24;15(4):1057. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10147008/
105.Lopresti AL, Drummond PD, Smith SJ. A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagandha (Withania somnifera) in Aging, Overweight Males. American Journal of Men’s Health [Internet]. 2019 Mar;13(2):155798831983598. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles /PMC6438434/
106.Morales-Brown P. Ashwagandha: Health benefits, side effects, and how to use [Internet]. www.medicalnewstoday.com. 2020. Available from: https://www.medicalnews today.com/articles/318407
107.Xing D, Yoo C, Gonzalez D, Jenkins V, Nottingham K, Dickerson B, et al. Effects of Acute Ashwagandha Ingestion on Cognitive Function. International Journal of Environmental Research and Public Health. 2022 Sep 20;19(19):11852.
108.Lopresti AL, Smith SJ. Ashwagandha (Withania somnifera) for the treatment and enhancement of mental and physical conditions: A systematic review of human trials. Journal of Herbal Medicine. 2021 Aug;28:100434.
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Nov 18, 2024
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Pratham M Gurav, Dr. Deepak Pokharkar, & Dr. Rupesh Pingale. (2024). IMMUNEBOOSTING HERBS TRADITIONALLY USED IN HOUSEHOLDS. Journal of Population Therapeutics and Clinical Pharmacology, 31(11), 2691-2704. https://doi.org/10.53555/cpzbr369
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Author Biographies
Pratham M Gurav
Pratham M Gurav Department of Quality Assurance M-Pharm , NCRD’S Sterling Institute of Pharmacy , Navi Mumbai , India .
Dr. Deepak Pokharkar
Dr. Deepak Pokharkar Department of Quality Assurance.
Dr. Rupesh Pingale
Dr. Rupesh Pingale Department of Pharmacognosy.
How to Cite
Pratham M Gurav, Dr. Deepak Pokharkar, & Dr. Rupesh Pingale. (2024). IMMUNEBOOSTING HERBS TRADITIONALLY USED IN HOUSEHOLDS. Journal of Population Therapeutics and Clinical Pharmacology, 31(11), 2691-2704. https://doi.org/10.53555/cpzbr369