STUDY OF ASSOCIATION OF LIPID PROFILE WITH CHOLELITHIASIS IN A TERTIARY CARE HOSPITAL
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Keywords
Cholelithiasis, Gallstones, Lipid profile
Abstract
Background: Gallstone disease (GSD) is the most common disorder affecting the biliary system and is also the most common gastro-intestinal disorder requiring hospitalisation. Gallstones in patients without biliary symptoms are commonly diagnosed incidentally on ultrasonography, CT scans, and abdominal radiography. But, there is lack of evidence regarding relation of cholelithiasis and lipid profile. In this study the association of serum lipids to cholelithiasis has been tried to been elucidated. Methods: A Cross sectional study amongst 78patients was conducted at Government medical college ,Rajnandgaon. All patients with GSD coming to the general surgery OPD above 18years were included in the study with few exclusion criteria. The diagnoses of gallstones were confirmed by ultrasound (USG) and venous blood sample was used to estimate lipid profile. All data were entered on a personal computer in Microsoft Excel and analysed using SPSS version 20 software. Descriptive data is given in frequency and percentage. Chi-square was used to find the association between different variables.
Results: In our study of 78 patients, mean difference of the lipid profile had a statistically significantly association with the weight of the stone. All biochemical parameters like T.Cholestrol, TGL, HDL, LDL and VLDL were compared and showed a p-value of less than 0.005. Serum SGOT, SGPT & TGL had a statistical significant association with average weight of stone. (p=0.050).
Conclusion: Biochemical parameters like SGOT, SGPT, and ALP influenced the type and weight of stone significantly. Similarly, while comparing the weight of the stone with lipid profile, a significant association was observed.
References
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Dr Kumar Yogesh
Senior Resident, Department Of Pathology, SNMMCH Dhanbad.
Dr Anish Deepak Baxla
Senior Resident, Department Of Surgery, RIMS, Ranchi.
Dr Deepak Kumar kachhap
Junior Resident, Department Of Surgery, RIMS, Ranchi.
Dr Rishabh Bhagwat
MBBS, BRLS ABVMMC, Rajnandgaon.