“LEPTIN AND ADIPONECTIN AS PREDICTING BIOMARKERS IN PREECLAMPSIA.”
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Keywords
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Abstract
Preeclampsia is a pregnancy related disorder involving multiple organs like liver, brain and symptoms resolve after termination pregnancy. HELLP syndrome is a complication of preeclampsia characterized by hemolysis, elevated liver enzymes and low platelets.
References
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2. Martinez-Fierro ML, Garza-Veloz I, Carrillo-Sanchez K, et al. (2014). Expression levels of seven candidate genes in human peripheral blood mononuclear cells and their association with preeclampsia. Hypertens Pregnancy, 33: 191–203.
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5. Eleuterio NM, Palei AC, Rangel Machado JS, Tanus-Santos JE, Cavalli RC, Sandrim VC. (2015). Positive correlations between circulating adiponectin and MMP2 in preeclampsia pregnant. Pregnancy Hypertens, 5: 205–208.
6. Sudjai D. Association of pre-pregnancy body mass index with early- and late-onset severe preeclampsia. Eur J Obstet Gynecol Reprod Biol X 2023; 19: 100223.
7. Miller GJ. Dietary fatty acids and blood coagulation. Prostaglandins Leukot Essent Fatty Acids 1997; 57: 389-394.
8. Dusse LM, Rios DRA, Pinheiro MB, Cooper AJ, Waleed BA. Preeclampsia: relationship between coagulation, fibrinolysis and inflammation. Clin Chim Acta 2011; 412: 17-21.
9. Schwingshackl L, Hoffmann G. Monounsaturated fatty acids and risk of cardiovascular disease: synopsis of the evidence available from systematic reviews and meta-analyses. Nutrients 2012; 4: 1989-2007.
10. Thagaard IN, Hedley PL, Holm JC, Lange T, Larsen T, Krebs L, Christiansen M. Leptin and Adiponectin as markers for preeclampsia in obese pregnant women, a cohort study. Pregnancy Hypertens 2019; 15: 78-83.
11. Robinson NJ, Minchell LJ, Mys JE, Hubel CA, Crocker IP. A potential role for free fatty acids in the pathogenesis of preeclampsia. J Hypertens 2009; 27: 1293-1302.
12. Herlambang H, Puspasari A, Maharani C, Enis RN, Tarawifa S, Fitri AD, Harahap H, Harahap AH, Kusdiyah E, Syamsunarno MRAA. Comprehensive fatty acid fractionation profilling in preeclampsia: a case control study with multivariable analysis. BMC Pregnancy Childbirth 2022; 22: 8.
13. Zorena K, Jachimowicz-Duda O, Ślęzak D, Robakowska M, Mrugacz M. Adipokines and Obesity. Potential Link to Metabolic Disorders and Chronic Complications. Int J Mol Sci 2020; 21: 3570.
14. Masuzaki H, Ogawa Y, Sagawa N, Hosoda K, Matsumoto T, et al. (1997) Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans. Nat Med 3: 1029- 1033
2. Martinez-Fierro ML, Garza-Veloz I, Carrillo-Sanchez K, et al. (2014). Expression levels of seven candidate genes in human peripheral blood mononuclear cells and their association with preeclampsia. Hypertens Pregnancy, 33: 191–203.
3. Khosrowbeygi A, Ahmadvand H. (2013). Leptin to adiponectin ratio in preeclampsia. Bangladesh Med Res Counc Bull, 39: 18–21.
4. Machado JS, Cavalli RC, Sandrim VC, et al. (2012). PP002. Study of polymorphisms of the adiponectin gene in women with gestational hypertension and preeclampsia. Pregnancy Hypertens, 2(3): 241
5. Eleuterio NM, Palei AC, Rangel Machado JS, Tanus-Santos JE, Cavalli RC, Sandrim VC. (2015). Positive correlations between circulating adiponectin and MMP2 in preeclampsia pregnant. Pregnancy Hypertens, 5: 205–208.
6. Sudjai D. Association of pre-pregnancy body mass index with early- and late-onset severe preeclampsia. Eur J Obstet Gynecol Reprod Biol X 2023; 19: 100223.
7. Miller GJ. Dietary fatty acids and blood coagulation. Prostaglandins Leukot Essent Fatty Acids 1997; 57: 389-394.
8. Dusse LM, Rios DRA, Pinheiro MB, Cooper AJ, Waleed BA. Preeclampsia: relationship between coagulation, fibrinolysis and inflammation. Clin Chim Acta 2011; 412: 17-21.
9. Schwingshackl L, Hoffmann G. Monounsaturated fatty acids and risk of cardiovascular disease: synopsis of the evidence available from systematic reviews and meta-analyses. Nutrients 2012; 4: 1989-2007.
10. Thagaard IN, Hedley PL, Holm JC, Lange T, Larsen T, Krebs L, Christiansen M. Leptin and Adiponectin as markers for preeclampsia in obese pregnant women, a cohort study. Pregnancy Hypertens 2019; 15: 78-83.
11. Robinson NJ, Minchell LJ, Mys JE, Hubel CA, Crocker IP. A potential role for free fatty acids in the pathogenesis of preeclampsia. J Hypertens 2009; 27: 1293-1302.
12. Herlambang H, Puspasari A, Maharani C, Enis RN, Tarawifa S, Fitri AD, Harahap H, Harahap AH, Kusdiyah E, Syamsunarno MRAA. Comprehensive fatty acid fractionation profilling in preeclampsia: a case control study with multivariable analysis. BMC Pregnancy Childbirth 2022; 22: 8.
13. Zorena K, Jachimowicz-Duda O, Ślęzak D, Robakowska M, Mrugacz M. Adipokines and Obesity. Potential Link to Metabolic Disorders and Chronic Complications. Int J Mol Sci 2020; 21: 3570.
14. Masuzaki H, Ogawa Y, Sagawa N, Hosoda K, Matsumoto T, et al. (1997) Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans. Nat Med 3: 1029- 1033
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Published
Oct 09, 2025
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Shubhangidevi H. Gawade, Dr. Pooja N.Joshi, Dr. G.A.Gulavani, & Dr Somnath Salgar. (2025). “LEPTIN AND ADIPONECTIN AS PREDICTING BIOMARKERS IN PREECLAMPSIA.”. Journal of Population Therapeutics and Clinical Pharmacology, 32(9), 191-194. https://doi.org/10.53555/dt8dma61
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Author Biographies
Shubhangidevi H. Gawade
(P.hD Student) Tutor, Department of Biochemistry, SKNMC& GH, Pune.
Dr. Pooja N.Joshi
(P.hD guide), Department of Biochemistry, Lecturer, BJMC, Pune
Dr. G.A.Gulavani
Professor and head, Dept. of Biochemistry, SKNMCGH, Pune
Dr Somnath Salgar
Professor and HOD Department of Biochemistry BJGMC, Pune
How to Cite
Shubhangidevi H. Gawade, Dr. Pooja N.Joshi, Dr. G.A.Gulavani, & Dr Somnath Salgar. (2025). “LEPTIN AND ADIPONECTIN AS PREDICTING BIOMARKERS IN PREECLAMPSIA.”. Journal of Population Therapeutics and Clinical Pharmacology, 32(9), 191-194. https://doi.org/10.53555/dt8dma61