“A COMPREHENSIVE REVIEW ON ORAL DISPERSIBLE TABLETS: INNOVATIONS, FORMULATION STRATEGIES AND FUTURE PROSPECTS”
Main Article Content
Keywords
Disintegration, Drug delivery system, Oral dispersible tablets, Super-disintegrants, Patented technologies
Abstract
Oral-dispersible tablets (ODTs) have emerged as an innovative dosage form that improves patient compliance and offers advantages over conventional tablets. These solid units rapidly disintegrate in the oral cavity, usually within one minute of contact with saliva, primarily due to the action of super-disintegrants. This makes ODTs particularly beneficial for pediatric and geriatric patients who experience swallowing difficulties. Various formulation approaches have been explored for ODT development, including direct compression, molding, melt granulation, phase-transition techniques, sublimation, lyophilization, and effervescent methods. Similar to conventional tablets, ODTs undergo evaluation for parameters such as hardness, friability, wetting time, moisture uptake, disintegration, and dissolution to ensure quality and performance.
References
1. Debjit B, Chiranjib B, Krishna K, Chandira RM. Fast dissolving tablet: An overview. J Chem Pharm Res 2009;1(1):163-77.
2. Sastry VS, Ram NJ, Joseph AF. Recent technological advances in oral drug delivery – A review. PSTT 2000; 3:139-44.
3. Mohanachandran PS, Krishna MohanPR (2010) Formulation and evaluation of mouth dispersible tablets of amlodipine besylate. Int J Appl Pharm 2:1-6 Sreenivas SA, Dandagi PM, Gadad AP, Godbloe AM, Hiremath SP, Mastiholimath VS. Oro-dispersible tablets: New-fangled drug delivery systems – A review. Indian J Pharm Educ Res 2005;39(4):177-81.
5. H. Drug-delivery products and the Zydis fast-dissolving dosage form. J Pharm Pharmacol 1998;50(4):375-82.
6. Fu Y, Yang S, Jeong SH, Kimura S, Park K. Orally fast disintegrating tablets: Developments, technologies, taste-masking and clinical studies. Crit Rev Ther Drug Carrier Syst 2004;21(6):433-76.
7. Brown D. Orally disintegrating tablets - Taste over speed. Drug Deliv Technol 2003; 3:58-61.
8. Jadhav SB, Kaudewar DR, Kaminwar GS, Jadhav AB, Kshirsagar R et al. (2011) Formulation and evaluation of dispersible tablets of diltiazem hydrochloride. Int J Pharmatech Res 3:1314-1321
9. Suthar RM, Chotai NP, Shah D (2013) Formulation and evaluation of fast dissolving tablets of ondansetron by solid dispersion in superdisintegrants. IJPER 47:49-55
10. Tuhina Banerjee. A Review on Fast Dissolving Films for Buccal Delivery of Low Dose Drugs. International Journal of Life Sciences and Review, 2015; 1(4): 117-123.
11. Preethi. S. Review on Dispersible Tablets: A New Endeavor in Drug Delivery System. International Journal of Pharmacy and Biological Sciences, 2019; 9(2): 1209-1222.
12. Mohire NC, Yadav AV, Gaikwad VK. Novel approaches in development of metronidazole Oro- dispersible tablets. Res J Pharm Technol. 2009; 2:283–6.
13. Morella AM, Pitman IH, Heinicke GW. Taste masked liquid suspensions. US Patent6. 2001:197–348.
14. Mahaveer PR, orally disintegrating tablets: A future prospectus, Int. J. Pharm. Sci. Bi. 1998; 3(1): 71-79.
15. Pahwa R, Piplani M, Sharma PC, Kaushik D, Nanda S, Orally disintegrating tablets-Friendly to pediatrics and geriatrics, Arch Appl. Sci. Res. 2010; 2(2): 35-48.
16. Sagar A, Prafulla S. Chaudhari, Rajesh J, Sandip SK, Rishikesh V., Trushal VC, Mouth Dissolving Tablets” An Innovative, IJPSR 2009;1(5):132.
17. Roy D, Bhowmik D, Sampath Kumar KP. A comprehensive review on superdisintegrants used in Oro- dispersible tablets. Ind J Res Pharma Biotech. 2014;2(4):1297-303.
18. Alexander Amit, Tripathi D K, Giri Tapan K, Khan Junaid, Suryawanshi Vijendra, Patel Ravish J. Review technologies influencing rapidly disintegrating drug delivery systems. Int J pharma Prof res. 2010;1(2):90-120.
19. Us D, Chaudhari P, Bhavsar D, Chavan R. Melt granulation: an alternative to traditional granulation techniques. Indian Drugs, 2013; 50(03).
20. Agrawal R, Naveen Y. Pharmaceutical processing–A review on wet granulation technology. Int J Pharm Front Res, 2011; 1(1): 65–83.
21. Parkash V, Maan S, Deepika, Yadav SK, Hemlata, Jogpal V. Fast disintegrating tablets: Opportunity in drug delivery system. Journal of Advanced Pharmaceutical Technology and Research 2011;2(4):223-235.
22. Singh S, Nautiyal U, Singh R, Kaur S. Fast dissolving tablets – future aspects. International Journal of Pharmaceutical and Biomedical Research 2015;3(2):216-231.
23. Ashish P, Harsoliya MS, Pathan JK, Shruti S. A review - Formulation of mouth dissolving tablet. International Journal of Pharmacology and Clinical Sciences 2011;1(1):1-8.
24. Biradar SS, Bhagavati ST, Kuppasad IJ. Fast dissolving drug delivery systems: a brief overview. Internet J Pharmacol. 2006;4(2):1-7
25. Patel PB, Chaudhary A, Gupta GD. Fast dissolving drug delivery systems: an update. Pharma Bio World. 2006; 1:24-9.
26. Kaur T, Gill B, Kumar S, Gupta GD. Mouth dissolving tablets: a novel approach to drug delivery. Int J Curr Pharm Res. 2011;3(1):1-7.
27. Piplani M, Pahwa R, “Orally disintegrating tablet: friendly to pediatrics and geriatrics”. Arch. Apll. Sci. Res., 2010; 2(2): 35-48.
28. Saroha K, Mathur P, Verma S, Syan N, Kumar A: Mouth Dissolving Tablets: An Overview on Future Compaction in Oral Formulation Technologies. Der Pharmacia Sinica 2010; 1(1):179-187.
29. Virely P, Yarwood R: Zydis – a novel, Fast Dissolving Dosage Form. Manuf Chem 1990; 61: 36-37.
30. Wilson C.G., Washington N., Peach J., Murray G.R., Kennerley J: The behavior of a fast-dissolving dosage form (Expidet) followed by gscintigraphy. International Journal of Pharmaceutics 1987; 40: 119-123.
31. Kumar V. Dinesh, Sharma Ira, Sharma Vipin, A comprehensive review on fast dissolving tablet technology. Journal of Applied Pharmaceutical Science 2011; 01 (05):50-58.
32. Chaudhari PD, Chaudhari SP, Kolhe SR, Dave KV, More DM: Formulation and evaluation of fast dissolving tablets of famotidine. Indian Drugs 2005; 42: 641-649.
33. Khanna K, Xavier G, Joshi S K, Patel A, Khanna S, et al. (2016) Fast dissolving tablets-A novel approach. Inter Jo Pharm Res & Alli Scie 5:311-322
34. Gholve S, Kaware A, Thonte S, Kaudewar D, Bhusnure O, et al. (2018) Oro-dispersible tablets: a systematic review. World J Pharm Res 7:152-165
35. Singh K, Saroha K, Mohan R, Kumar A, Pandit C, et al. Oro-dispersible tablets: Development, technologies and evaluation: An overview. phar Rese 8:128-147
36. Patil PB, More VN, Tour NS (2015) Recent trends in Oro-dispersible tablets–An overview of formulation technology and future prospects. Inte J Pharma Scie Rese 6:1056-1066
37. VT P, Rane BR, Gujarathi NA, Bakliwal SR, Pawar SP, et al (2012) A Review On “Novel Concept Of Oral Fast Dissolving Tablet”. Pharma Research 8:15-37
38. Preethi S, Padmapriya S, Rajalakshmi AN (2019) “Review on Dispersible Tablets: A New Endeavor in Drug Delivery System”. Int J Pharm Biol Sci 9:1209-1222
2. Sastry VS, Ram NJ, Joseph AF. Recent technological advances in oral drug delivery – A review. PSTT 2000; 3:139-44.
3. Mohanachandran PS, Krishna MohanPR (2010) Formulation and evaluation of mouth dispersible tablets of amlodipine besylate. Int J Appl Pharm 2:1-6 Sreenivas SA, Dandagi PM, Gadad AP, Godbloe AM, Hiremath SP, Mastiholimath VS. Oro-dispersible tablets: New-fangled drug delivery systems – A review. Indian J Pharm Educ Res 2005;39(4):177-81.
5. H. Drug-delivery products and the Zydis fast-dissolving dosage form. J Pharm Pharmacol 1998;50(4):375-82.
6. Fu Y, Yang S, Jeong SH, Kimura S, Park K. Orally fast disintegrating tablets: Developments, technologies, taste-masking and clinical studies. Crit Rev Ther Drug Carrier Syst 2004;21(6):433-76.
7. Brown D. Orally disintegrating tablets - Taste over speed. Drug Deliv Technol 2003; 3:58-61.
8. Jadhav SB, Kaudewar DR, Kaminwar GS, Jadhav AB, Kshirsagar R et al. (2011) Formulation and evaluation of dispersible tablets of diltiazem hydrochloride. Int J Pharmatech Res 3:1314-1321
9. Suthar RM, Chotai NP, Shah D (2013) Formulation and evaluation of fast dissolving tablets of ondansetron by solid dispersion in superdisintegrants. IJPER 47:49-55
10. Tuhina Banerjee. A Review on Fast Dissolving Films for Buccal Delivery of Low Dose Drugs. International Journal of Life Sciences and Review, 2015; 1(4): 117-123.
11. Preethi. S. Review on Dispersible Tablets: A New Endeavor in Drug Delivery System. International Journal of Pharmacy and Biological Sciences, 2019; 9(2): 1209-1222.
12. Mohire NC, Yadav AV, Gaikwad VK. Novel approaches in development of metronidazole Oro- dispersible tablets. Res J Pharm Technol. 2009; 2:283–6.
13. Morella AM, Pitman IH, Heinicke GW. Taste masked liquid suspensions. US Patent6. 2001:197–348.
14. Mahaveer PR, orally disintegrating tablets: A future prospectus, Int. J. Pharm. Sci. Bi. 1998; 3(1): 71-79.
15. Pahwa R, Piplani M, Sharma PC, Kaushik D, Nanda S, Orally disintegrating tablets-Friendly to pediatrics and geriatrics, Arch Appl. Sci. Res. 2010; 2(2): 35-48.
16. Sagar A, Prafulla S. Chaudhari, Rajesh J, Sandip SK, Rishikesh V., Trushal VC, Mouth Dissolving Tablets” An Innovative, IJPSR 2009;1(5):132.
17. Roy D, Bhowmik D, Sampath Kumar KP. A comprehensive review on superdisintegrants used in Oro- dispersible tablets. Ind J Res Pharma Biotech. 2014;2(4):1297-303.
18. Alexander Amit, Tripathi D K, Giri Tapan K, Khan Junaid, Suryawanshi Vijendra, Patel Ravish J. Review technologies influencing rapidly disintegrating drug delivery systems. Int J pharma Prof res. 2010;1(2):90-120.
19. Us D, Chaudhari P, Bhavsar D, Chavan R. Melt granulation: an alternative to traditional granulation techniques. Indian Drugs, 2013; 50(03).
20. Agrawal R, Naveen Y. Pharmaceutical processing–A review on wet granulation technology. Int J Pharm Front Res, 2011; 1(1): 65–83.
21. Parkash V, Maan S, Deepika, Yadav SK, Hemlata, Jogpal V. Fast disintegrating tablets: Opportunity in drug delivery system. Journal of Advanced Pharmaceutical Technology and Research 2011;2(4):223-235.
22. Singh S, Nautiyal U, Singh R, Kaur S. Fast dissolving tablets – future aspects. International Journal of Pharmaceutical and Biomedical Research 2015;3(2):216-231.
23. Ashish P, Harsoliya MS, Pathan JK, Shruti S. A review - Formulation of mouth dissolving tablet. International Journal of Pharmacology and Clinical Sciences 2011;1(1):1-8.
24. Biradar SS, Bhagavati ST, Kuppasad IJ. Fast dissolving drug delivery systems: a brief overview. Internet J Pharmacol. 2006;4(2):1-7
25. Patel PB, Chaudhary A, Gupta GD. Fast dissolving drug delivery systems: an update. Pharma Bio World. 2006; 1:24-9.
26. Kaur T, Gill B, Kumar S, Gupta GD. Mouth dissolving tablets: a novel approach to drug delivery. Int J Curr Pharm Res. 2011;3(1):1-7.
27. Piplani M, Pahwa R, “Orally disintegrating tablet: friendly to pediatrics and geriatrics”. Arch. Apll. Sci. Res., 2010; 2(2): 35-48.
28. Saroha K, Mathur P, Verma S, Syan N, Kumar A: Mouth Dissolving Tablets: An Overview on Future Compaction in Oral Formulation Technologies. Der Pharmacia Sinica 2010; 1(1):179-187.
29. Virely P, Yarwood R: Zydis – a novel, Fast Dissolving Dosage Form. Manuf Chem 1990; 61: 36-37.
30. Wilson C.G., Washington N., Peach J., Murray G.R., Kennerley J: The behavior of a fast-dissolving dosage form (Expidet) followed by gscintigraphy. International Journal of Pharmaceutics 1987; 40: 119-123.
31. Kumar V. Dinesh, Sharma Ira, Sharma Vipin, A comprehensive review on fast dissolving tablet technology. Journal of Applied Pharmaceutical Science 2011; 01 (05):50-58.
32. Chaudhari PD, Chaudhari SP, Kolhe SR, Dave KV, More DM: Formulation and evaluation of fast dissolving tablets of famotidine. Indian Drugs 2005; 42: 641-649.
33. Khanna K, Xavier G, Joshi S K, Patel A, Khanna S, et al. (2016) Fast dissolving tablets-A novel approach. Inter Jo Pharm Res & Alli Scie 5:311-322
34. Gholve S, Kaware A, Thonte S, Kaudewar D, Bhusnure O, et al. (2018) Oro-dispersible tablets: a systematic review. World J Pharm Res 7:152-165
35. Singh K, Saroha K, Mohan R, Kumar A, Pandit C, et al. Oro-dispersible tablets: Development, technologies and evaluation: An overview. phar Rese 8:128-147
36. Patil PB, More VN, Tour NS (2015) Recent trends in Oro-dispersible tablets–An overview of formulation technology and future prospects. Inte J Pharma Scie Rese 6:1056-1066
37. VT P, Rane BR, Gujarathi NA, Bakliwal SR, Pawar SP, et al (2012) A Review On “Novel Concept Of Oral Fast Dissolving Tablet”. Pharma Research 8:15-37
38. Preethi S, Padmapriya S, Rajalakshmi AN (2019) “Review on Dispersible Tablets: A New Endeavor in Drug Delivery System”. Int J Pharm Biol Sci 9:1209-1222
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Published
Sep 30, 2025
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How to Cite
Deep Shah, Ms. Nirzari Antani, & Dr. Pragnesh Patani. (2025). “A COMPREHENSIVE REVIEW ON ORAL DISPERSIBLE TABLETS: INNOVATIONS, FORMULATION STRATEGIES AND FUTURE PROSPECTS”. Journal of Population Therapeutics and Clinical Pharmacology, 32(7), 1890-1898. https://doi.org/10.53555/dy6v3148
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Author Biographies
Deep Shah
Khyati College of Pharmacy, Palodia, Ahmedabad
Ms. Nirzari Antani
Khyati College of Pharmacy, Palodia, Ahmedabad
Dr. Pragnesh Patani
Khyati College of Pharmacy, Palodia, Ahmedabad
How to Cite
Deep Shah, Ms. Nirzari Antani, & Dr. Pragnesh Patani. (2025). “A COMPREHENSIVE REVIEW ON ORAL DISPERSIBLE TABLETS: INNOVATIONS, FORMULATION STRATEGIES AND FUTURE PROSPECTS”. Journal of Population Therapeutics and Clinical Pharmacology, 32(7), 1890-1898. https://doi.org/10.53555/dy6v3148