STATUS OF OXIDATIVE STRESS IN HYPOTHYROID INDIVIDUALS
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Abstract
Introduction- Numerous metabolic processes are regulated by thyroid hormone. A clinical condition known as hypothyroidism is characterized by decreased thyroid activity. One of the side effects of thyroid hormone abnormalities is oxidative stress. The purpose of this study was to assess the antioxidant status and oxidative stress indicators in hypothyroidism patients.
Material and Methods- In all, 540 participants were enrolled in the trial, including 270 patients with thyroid hormone deficiency (of which 153 had hypothyroidism) and a control group of 153 healthy patients. A venipuncture was used to draw about five milliliters (5 mL) of blood from each participant, which was then poured into a sterile, simple container. The activities of glutathione, malondialdehyde, and catalase were assessed using spectrophotometry using a UV Visible spectrophotometer.
Result- MDA levels, a measure of oxidative stress and lipid peroxidation, were considerably higher in the hypothyroid group (6.86 ± 1.76 nmol/mL) than in the control group (4.86 ± 0.7 nmol/mL), suggesting that hypothyroid people experience higher levels of oxidative stress. On the other hand, the hypothyroid group had significantly decreased antioxidant defence markers. GSH levels were also considerably lower (60.36 ± 7.43 nmol/mL) than controls (116 ± 13.08 nmol/mL), and catalase activity was decreased to 111 ± 14.49 nmol/mL in hypothyroid patients versus 163 ± 15.99 nmol/mL in controls.
Conclusion- The pathogenesis and problems linked to thyroid dysfunction may be exacerbated by hypothyroid individuals' increased oxidative stress and compromised antioxidant defences
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Vaishali Singh
Ph D Scholar, Department of Biochemistry, Index Medical College, Hospital & Research Centre, Indore
Dr. Shreya Nigoskar
Professor and Head, Department of Biochemistry, Index Medical College, Hospital & Research Centre, Indore