A STUDY OF MUCOCUTANEOUS MANIFESTATIONS IN HIV-INFECTED PATIENTS PRESENTING TO A TERTIARY CARE INSTITUTE IN PUNJAB.
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Keywords
Mucocutaneous, HIV, CD4, Skin in HIV
Abstract
Human immunodeficiency virus (HIV) infection & Acquired immunodeficiency syndrome (AIDS) have been a significant public health concern worldwide with an estimated global prevalence of 40.8 million people.[1] According to latest NACO guidelines, Punjab has a high prevalence of HIV – 0.42% in 2023. Mucocutaneous diseases are common in HIV infection and they increase in frequency and severity with progression of infection and declining CD4 counts. They can function as visual markers of disease progression especially in regions with insufficient resources to test CD4 T cell counts & HIV viral load.[2–4] Being an easily assessable site for examination & biopsy, the skin can give a clue to underlying immune status, hence, evaluation of skin plays an important role in HIV infected patients. The present study was conducted to determine the pattern & prevalence of mucocutaneous manifestations in HIV positive patients and their correlation with CD4 counts in a tertiary care institute.
References
2. Kanwar A, Vinay K, Wanchu A, Kore S. Pattern of mucocutaneous manifestations in human immunodeficiency virus-positive patients in North India. Indian J Sex Transm Dis AIDS. 2013;34:19-24.
3. Kumarasamy N, Solomon S, Madhivanan P, Ravikumar B, Thyagarajan SP, Yesudian P. Dermatologic manifestations among human immunodeficiency virus patients in south India. Int J Dermatol. 2000;39:192–5.
4. Singh H, Singh P, Tiwari P, Dey V, Dulhani N, Singh A. Dermatological manifestations in HIV-infected patients at a tertiary care hospital in a tribal (Bastar) region of Chhattisgarh, India. Indian J Dermatol. 2009;54:338-41.
5. Smith KJ, Skelton HG, Yeager J, Ledsky R, McCarthy W, Baxter D, et al. Cutaneous findings in HIV-1-positive patients: a 42-month prospective study. Military Medical Consortium for the Advancement of Retroviral Research (MMCARR). J Am Acad Dermatol. 1994;31:746–54.
6. Ashwini PK, Betkerur J, Shastry V. Study of mucocutaneous manifestations of HIV and its relation to total lymphocyte count. Indian J Sex Transm Dis AIDS. 2020 Jan-Jun;41(1):47-52.
7. Mirnezami M, Zarinfar N, Sofian M, Botlani Yadegar B, Rahimi H. Mucocutaneous Manifestations in HIV-Infected Patients and Their Relationship to CD4 Lymphocyte Counts. Scientifica (Cairo). 2020 Aug 11;2020:7503756.
8. Sud N, Shanker V, Sharma A, Sharma NL, Gupta M. Mucocutaneous manifestations in 150 HIV-infected Indian patients and their relationship with CD4 lymphocyte counts. Int J STD AIDS. 2009;20:771–4.
9. Ali Azfar N., Khan A., Zia M., et al. Frequency of mucocutaneous manifestations in HIV positive Pakistani patients. Journal of Pakistan Association of Dermatology. 2011;21:149–153
10. Fernandes M. S., Bhat R. M. Spectrum of mucocutaneous manifestations in human immunodeficiency virus-infected patients and its correlation with CD4 lymphocyte count. International Journal of STD & AIDS. 2015;26(6):414–419
11. Chawhan S, Bhat D, Solanke S. Dermatological manifestations in human immunodeficiency virus infected patients: Morphological spectrum with CD4 correlation. Indian J Sex Transm Dis AIDS. 2013;34:89-94.
12. Vasudevan B, Sagar A, Bahal A, Mohanty A. Cutaneous manifestations of HIV-a detailed study of morphological variants, markers of advanced disease, and the changing spectrum. Med J Armed Forces India. 2012;68:20–7.
13. Wiwanitkit V. Prevalence of dermatological disorders in Thai HIV-infected patients correlated with different CD4 lymphocyte count statuses: a note on 120 cases. Int J Dermatol. 2004;43:265–8.
14. Tschachler E, Bergstresser PR, Stingl G. HIV-related skin diseases. Lancet. 1996;348:659–63.
15. Coldiron BM, Bergstresser PR. Prevalence and clinical spectrum of skin disease in patients infected with human immunodeficiency virus. Arch Dermatol. 1989;125:357–61.
16. Goodman DS, Teplitz ED, Wishner A, Klein RS, Burk PG, Hershenbaum E. Prevalence of cutaneous disease in patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related complex. J Am Acad Dermatol. 1987;17:210–20.
17. Weinberg JL, Kovarik CL. The WHO clinical staging system for HIV/AIDS. Virtual Mentor VM. 2010;12:202–6.
18. Akinboro AO, Onayemi O, Mejiuni AD. Frequency, pattern, and extent of skin diseases in relation to CD4+ cell count among adults with human immunodeficiency virus infection or acquired immunodeficiency syndrome in Osogbo, southwestern Nigeria. Int J Dermatol. 2014;53:416–24.
19. Muñoz-Pérez MA, Rodriguez-Pichardo A, Camacho F, Colmenero MA. Dermatological findings correlated with CD4 lymphocyte counts in a prospective 3 year study of 1161 patients with human immunodeficiency virus disease predominantly acquired through intravenous drug abuse. Br J Dermatol. 1998;139:33–9.
20. Sadick N, Kaplan MH, Pahwa SG, Sarngadharan MG. Unusual features of scabies complicating human T-lymphotropic virus type III infection. J Am Acad Dermatol. 1986;15:482–6.
21. Brancato L, Itescu S, Skovron ML, Solomon G, Winchester R. Aspects of the spectrum, prevalence and disease susceptibility determinants of Reiter’s syndrome and related disorders associated with HIV infection. Rheumatol Int. 1989;9:137–41.
22. Lahoti S, Rao K, Umadevi HS, Mishra L. Correlation of mucocutaneous manifestations of HIV-infected patients in an ART center with CD4 counts. Indian J Dent Res. 2017;28:549.
23. Noruka E. N., Chukwuka J. C., Anisuiba B. Correlation of mucocutaneous manifestations of HIV/AIDS infection with CD4 counts and disease progression. International Journal of Dermatology. 2007;46:14–18
24. Fernandes S, Pinto GM, Cardoso J. Particular clinical presentations of psoriasis in HIV patients. Int J STD AIDS. 2011;22:653–4.
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Naiyna Nangia
Ex Resident, Christian Medical College, Ludhiana naiynanangia@gmail.com
Anuradha Bhatia
Associate Professor Department of Dermatology, Dr BR Ambedkar State Insitute of Medical sciences, Mohali.
Bimal Kanish
Ex Professor, Christian Medical College, Ludhiana drbimalkanish@yahoo.co.in
Navjot Singh
Professor, Medicine, Christian Medical College, Ludhiana navjotmed@rediffmail.com