THE COMPREHENSIVE STUDY ON RISK OF AVN FEMUR IN LONG TERM STEROID USE
Main Article Content
Keywords
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Abstract
This dissertation investigates the correlation between long-term steroid use in asthmatic patients and the incidence of avascular necrosis of the femur, addressing a critical gap in understanding the potential complications associated with prolonged glucocorticoid therapy. Through a comprehensive analysis of longitudinal clinical data comprising patient medical histories, treatment duration, dosage of steroids, and prevalence rates of avascular necrosis, the study identifies a statistically significant increase in the risk of femoral avascular necrosis among patients undergoing long-term steroid treatment. The findings emphasize the necessity for vigilant clinical monitoring and risk assessment in asthmatics receiving glucocorticoids, highlighting that even moderate dosages over extended periods can lead to severe orthopedic complications. Moreover, the results suggest that healthcare providers need to consider alternative treatment strategies and proactive measures to mitigate this risk, promoting personalized medicine approaches tailored to minimize steroid use while effectively managing asthma. By illuminating the relationship between steroid therapy and avascular necrosis, this research contributes to the existing body of literature on chronic disease management and underscores the importance of balancing therapeutic efficacy with potential long-term health outcomes, thereby influencing future guidelines and clinical practices in the treatment of asthmatic patients.
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● James Varley, Christine Strippel, Adam E. Handel, Sarosh R. Irani. "Autoimmune encephalitis: recent clinical and biological advances" Journal of Neurology, 2023, 4118-4131. doi: https://doi.org/10.1007/ s00415-023-11685-3
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● Tarraf, Nour Eldin. "A study of the influence of combined Glucosamine Sulfate and Chondroitin Sulfate systemic supplements on root resorption and tooth movement in rats" 'Cumhuriyet University Faculty Dentistry', 2008, doi: https://core.ac.uk/download/41232345.pdf
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● Agius, Adrian M., Ahlstrom-Emanuelsson, Cecilia, Al-Qudah, Mohannad, Alabri, et al.. "European Position Paper on Rhinosinusitis and Nasal Polyps 2020" 2020, doi: https://core.ac.uk /download /401693924.pdf
● Alobid, Isam, Anselmo-Lima, Wilma Terezinha, Bachert, Claus, Baroody, et al.. "European position paper on rhinosinusitis and nasal polyps 2020" 'Rhinology', 2020, doi: https://core.ac.uk/ download/288799867.pdf
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● TABLECorticosteroids and Musculoskeletal Adverse Events. "Corticosteroids and Musculoskeletal Adverse Events." *New Zealand Medicines and Medical Devices Safety Authority*, 2012, https://www.medsafe.govt.nz/profs/PUArticles/Dec2012Corticosteroids. htm.*Note.* Adapted from Corticosteroids and Musculoskeletal Adverse Events, by Corticosteroids and Musculoskeletal Adverse Events, 2012, New Zealand Medicines and Medical Devices Safety Authority, Prescriber Update, 33(4), p. 37-38. Retrieved from https://www.medsafe.govt.nz/profs/PUArticles/Dec2012Corticosteroids.htm.George Kwok Chu Wong, Wai Sang Poon, Kwok Hing Chiu. "Steroid-induced avascular necrosis of the hip in neurosurgical patients: epidemiological study." **, 2005, https://pubmed.ncbi.nlm.nih.gov/ 15943727/.*Note.* Adapted from Steroid-induced avascular necrosis of the hip in neurosurgical patients: epidemiological study, by George Kwok Chu Wong, Wai Sang Poon, Kwok Hing Chiu, 2005, ANZ J Surg, 75(6), p. 409-410. Retrieved from https://pubmed.ncbi.nlm.nih.gov/1594 3727/.Sarah E Grond, Ryan E Little, David A Campbell, Todd A Loehrl, David M Poetker. "Oral corticosteroid use and the risk of developing avascular necrosis: A large retrospective review." **, 2022, https://pubmed.ncbi.nlm.nih.gov/34918464/.*Note.* Adapted from Oral corticosteroid use and the risk of developing avascular necrosis: A large retrospective review, by Sarah E Grond, Ryan E Little, David A Campbell, Todd A Loehrl, David M Poetker, 2022, Int Forum Allergy Rhinol, Vol 12, Issue 7, p. 903-909. Retrieved from https://pubmed.ncbi.nlm.nih.gov/34918 464/.Kiriakos Karkoulias, Nikos Charokopos, Alexander Kaparianos, Fotis Sampsonas, Maria Tsiamita, Kostas Spiropoulos. "Aseptic femoral head necrosis in a patient receiving long term courses of inhaled and intranasal corticosteroids." *Tuberk Toraks*, 2007, https://pubmed.ncbi.nlm.nih.gov/ 17602347/.*Note.* Adapted from Aseptic femoral head necrosis in a patient receiving long term courses of inhaled and intranasal corticosteroids, by Kiriakos Karkoulias, Nikos Charokopos, Alexander Kaparianos, Fotis Sampsonas, Maria Tsiamita, Kostas Spiropoulos, 2007, Tuberk Toraks, Tuberk Toraks, 55(2), p. 182-185. Retrieved from https://pubmed.ncbi.nlm.nih.gov/17602347/.Prathiba Annam, Anusha Manda, Uday Krishna Myneni, Aaminah Najmus Sahar, Nagendra Prasad, Kezia K Sam, Sambit Sahu, Kiran Kumar Reddy. "Corticosteroids induced avascular necrosis of hip, a “long COVID-19” complication: Case report." *Annals of Medicine and Surgery*, 2022, https://pmc.ncbi.nlm.nih.gov/articles /PMC9500083/.*Note.* Adapted from Corticosteroids induced avascular necrosis of hip, a “long COVID-19” complication: Case report, by Prathiba Annam, Anusha Manda, Uday Krishna Myneni, Aaminah Najmus Sahar, Nagendra Prasad, Kezia K Sam, Sambit Sahu, Kiran Kumar Reddy, 2022, Annals of Medicine and Surgery, Ann Med Surg (Lond), 82, p. 104753. Retrieved from https://pmc.ncbi.nlm.nih.gov/articles/PMC9500083/.Murat Çalapkulu, Muhammed Kızılgül, Muhammed Erkam Sencar, Hakan Düğer, Bekir Uçan, Erman Çakal, Mustafa Özbek. "Avascular necrosis of the femoral head due to low-dose corticosteroid used in a patient with panhypopituitarism: A case report and literature review." **, 2025, https://www.jointdrs.org/full-text/1138.*Note.* Adapted from Avascular necrosis of the femoral head due to low-dose corticosteroid used in a patient with panhypopituitarism: A case report and literature review, by Murat Çalapkulu, Muhammed Kızılgül, Muhammed Erkam Sencar, Hakan Düğer, Bekir Uçan, Erman Çakal, Mustafa Özbek, 2025. Retrieved from https://www.jointdrs.org/full-text/1138.
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Mar 26, 2024
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Dr. Sahil, Dr. Rohit, Dr. Rupam, & Dr. Shekhar Saini. (2024). THE COMPREHENSIVE STUDY ON RISK OF AVN FEMUR IN LONG TERM STEROID USE. Journal of Population Therapeutics and Clinical Pharmacology, 31(3), 2647-2659. https://doi.org/10.53555/b8m1nq17
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Author Biographies
Dr. Sahil
(https://orcid.org/0009-0004-2775-7481)
Dr. Rohit
(https://orcid.org/0009-0007-5987-6380)
Dr. Rupam
(https://orcid.org/0009-0001-3782-4164)
Dr. Shekhar Saini
(https://orcid.org/0009-0003-0933-463X)
How to Cite
Dr. Sahil, Dr. Rohit, Dr. Rupam, & Dr. Shekhar Saini. (2024). THE COMPREHENSIVE STUDY ON RISK OF AVN FEMUR IN LONG TERM STEROID USE. Journal of Population Therapeutics and Clinical Pharmacology, 31(3), 2647-2659. https://doi.org/10.53555/b8m1nq17