ASSESSMENT OF SERUM CALCIUM AND PHOSPHORUS LEVELS IN PATIENTS OF HYPERTHYROIDISM VISITING A TERTIARY CARE HOSPITAL IN THE MORADABAD REGION
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Keywords
Hyperthyroidism, calcium, phosphorus, T3, T4, TSH
Abstract
Background: The thyroid gland is essential for regulating growth, development, and metabolism in human body. When thyroid function becomes abnormal, it can disrupt the balance the balance of minerals like calcium and phosphorus. A reduced bone mineral density and a higher chance of fractures are often associated with hyperthyroidism. As a result, individuals with hyperthyroidism are at a higher risk of developing secondary osteoporosis.
Objectives: To analyze serum calcium and phosphorus levels and investigate their possible association of T3, T4, and TSH in patients with hyperthyroidism who have recently been diagnosed.
Materials and Methods: This study was involving 84 hyperthyroid patients aged 20 to 60 years. Participants were selected from the outpatient and inpatient departments of Medicine at TMMC & RC, Moradabad, Uttar Pradesh. Serum calcium, phosphorus, and thyroid hormone levels were assessed using automated analytical methods.
Results: The findings revealed a strong, statistically significant positive correlation between serum calcium levels and both T3 (p < 0.001) and T4 ( p < 0.001). In contrast, TSH levels showed a strong, statistically significant negative correlation with calcium ( p < 0.001). However, no significant correlation was observed between serum phosphorus levels and any component of the thyroid profile. Additionally, the study noted a higher prevalence of female patients compared to male patients of hyperthyroidism. .
Conclusion: Hyperthyroidism is among the most common endocrine disorders. Elevated levels of thyroid hormones can lead to changes in serum mineral concentration. Monitoring these mineral levels can aid in the effective management of hyperthyroidism and help in prevent potential complications like loss of bone density, muscle weakness, irregular heartbeat. It may also serve as a valuable tool for both diagnosis and prognosis of hyperthyroidism.
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Adeeba
MSc Medical Biochemistry, Department of Biochemistry, Teerthanker Mahaveer Medical College & Research Centre, Moradabad (U.P) India.
Dr. Reena Rani
Associate Professor, Department of Biochemistry, Teerthanker Mahaveer Medical College & Research Centre, Moradabad (U.P) India.
Dr. Pothu Usha Kiran
Professor & Head, Department of Biochemistry, Teerthanker Mahaveer Medical College & Research Centre, Moradabad (U.P) India.
Dr. Jigar Haria
Professor Department of Medicine, Teerthanker Mahaveer Medical College & Research Centre, Moradabad (U.P) India.