HEMATOLYMPHOID NEOPLASM IN PLEURAL EFFUSION: CYTOMORPHOLOGY AND IMMUNOCYTOCHEMISTRY- BASED CASE SERIES
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Keywords
Pleural fluid, Cytology, Chronic Myeloid Leukemia, Non-Hodgkin Lymphoma, Immunocytochemistry, Hematolymphoid malignancy
Abstract
Pleural effusion is a frequent finding in various malignancies, including hematolymphoid neoplasms. This case series highlights four cases where pleural fluid cytology played a crucial role in identifying underlying hematologic malignancies such as Acute Myeloid(AML), Non-Hodgkin Lymphoma (NHL) and Leukemic Infiltration. The application of immunocytochemistry alongside cytomorphology was pivotal in reaching a definitive diagnosis. This series emphasizes the utility of cytological analysis and the importance of considering hematolymphoid malignancies in the differential diagnosis of pleural effusion.
References
2. Khan NA, Whalen GF, Takayama TK, et al. Diagnostic approach to malignant pleural effusion. Chest. 2004;126(6):2294–2299. doi:10.1378/chest.126.6.2294.
3. Das DK. Serous effusions in malignant lymphomas: a cytomorphologic study with special reference to reactive processes. Diagn Cytopathol. 2006;34(5):335–342. doi:10.1002/dc.20434.
4. Gupta N, Rajwanshi A, Srinivasan R, Nijhawan R. Fine-needle aspiration cytology of extramedullary myeloid tumor: a study of 25 cases. Diagn Cytopathol. 2009;37(9):664–669. doi:10.1002/dc.21063.
5. Valdés L, Pose A, San José E, Martínez Vázquez JM. Diagnosis of malignant pleural effusions. Curr Opin Pulm Med. 2000;6(4):251–254. doi:10.1097/00063198-200007000-00009.
6. Chhieng DC, Cangiarella JF, Cohen JM. Cytology of hematologic malignancies in effusions: a case-based review. Cancer Cytopathol. 2001;93(3):187–198. doi:10.1002/cncr.9028.
7. Pérez-Guillén I, Llorente C, Torrente M, et al. Diagnostic yield of cytology and immunocytochemistry in malignant effusions: a study of 257 samples. Cytojournal. 2019;16:7. doi:10.4103/cytojournal.cytojournal_5_19 effusions
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Anubhi Ranjan
Junior Resident 3, Department of Pathology, Sri Ram Murti Smarak Institute of Medical Sciences, Bareilly, Uttar Pradesh.
Hema Pant
Professor, Department of Pathology, Sri Ram Murti Smarak Institute of Medical Sciences, Bareilly, Uttar Pradesh.
Shubhnita Garg
Assistant Professor, Department of Pathology, Sri Ram Murti Smarak Institute of Medical Sciences, Bareilly, Uttar Pradesh.