SEVERITY OF ACUTE PANCREATITIS: CORRELATING BISAP SCORE, POCUS, AND CT FINDINGS IN A TERTIARY EMERGENCY SETTING

Main Article Content

Dr Anjaly Jose
Dr Wajid Ali Gazi
Dr Sibit Showkat

Keywords

Acute pancreatitis, BISAP score, POCUS, CT findings, CTSI, prognostic scoring

Abstract

Acute pancreatitis (AP) presents with a wide spectrum of severity. Stratification must be done accurately and early in order to maximize management and enhance results. The objective of this investigation was to assess the correlation between the Bedside Index for Severity in Acute Pancreatitis (BISAP) score, point-of-care ultrasound (POCUS), and contrast-enhanced CT (CECT) findings in assessing the extent of AP and envisaging short-term clinical outcomes. A research of prospective research study was carried out on 100 patients presenting with AP over one year. BISAP scores were considered within 24 hours of admission. POCUS was performed on all patients, and CECT was performed when indicated. Associations among BISAP scores, ultrasound findings, CT severity index (CTSI), and six-week outcomes were analyzed using appropriate statistical tests. The majority (64%) of patients were aged between 30–60 years; 67% were female. Gallstones were the most common etiology (64%), followed by idiopathic causes (28%). BISAP score was 0–2 in 84% and 3–5 in 16%. All seven deaths occurred in the BISAP ≥3 group (p < 0.001). POCUS revealed pleural effusion in 30% and peripancreatic fluid in 45% of patients. Pleural effusion showed a significant implication with higher BISAP scores (p = 0.012), and the presence of both pleural effusion and fluid collections was also significantly related to severity (p = 0.039). CT was performed in 50% of patients; 46% had necrotizing pancreatitis. However, no statistically significant correlation was observed between BISAP and CTSI (p = 0.137). BISAP score calculated within 24 hours, when used in conjunction with early POCUS, offers a practical and reliable method for early risk stratification in AP. In resource-limited settings, this combined approach offers a fast, cost-effective, and evidence-based alternative to CT-based assessments.

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References

1. Szatmary P, Grammatikopoulos T, Cai W, et al. Acute pancreatitis: diagnosis and treatment. Drugs. 2022 Aug;82(12):1251-76.
2. Zerem E, Kurtcehajic A, Kunosić S, et al. Current trends in acute pancreatitis: Diagnostic and therapeutic challenges. World journal of gastroenterology. 2023 May 14;29(18):2747.
3. Kryvoruchko IA, Boyko VV, Sartelli M, et al. Pancreatic necrosis infection as a determinant of multiple organ failure and mortality in acute pancreatitis. Pathogens. 2023 Mar 8;12(3):428.
4. Zilio MB, Eyff TF, Azeredo-Da-Silva AL, et al. A systematic review and meta-analysis of the aetiology of acute pancreatitis. Hpb. 2019 Mar 1;21(3):259-67.
5. Chan KS, Shelat VG. Diagnosis, severity stratification, and management of adult acute pancreatitis–current evidence and controversies. World journal of gastrointestinal surgery. 2022 Nov 27;14(11):1179.
6. Cho JH, Kim TN, Chung HH, et al. Comparison of scoring systems in predicting the severity of acute pancreatitis. World J Gastroenterol. 2015 Feb 28;21(8):2387-94. doi: 10.3748/wjg.v21.i8.2387. PMID: 25741146; PMCID: PMC4342915.
7. Güzel YE, Çolak N, Okuv AC, et al. Comparing prognostic scoring systems in acute pancreatitis: Bedside Index of Severity in Acute Pancreatitis, WL, and Chinese Simple Scoring System Scores. Turk J Emerg Med. 2024 Jul 1;24(3):165-171. doi: 10.4103/tjem.tjem_14_24. PMID: 39108679; PMCID: PMC11299844.
8. Dumbrava BD. Point Of Care Ultrasound By Surgeons: A Multicentric Trial (POCUSS Trial) (Doctoral dissertation, Royal College of Surgeons in Ireland).
9. Chen X. Indications for contrast-enhanced computed tomography in patients with sepsis-induced acute kidney injury. Ann Transl Med. 2019 Oct;7(20):597. doi: 10.21037/atm.2019.09.145. PMID: 31807578; PMCID: PMC6861805.
10. Jin DX, Banks PA, McNabb‐Baltar J. Definition of Complications and Severity of Acute Pancreatitis for Clinical Practice. Clinical Pancreatology for Practising Gastroenterologists and Surgeons. 2021 Jun 30:25-30.
11. Sorgente V, Di Serafino M, Varriano G, et al. Early prediction of the evolution and prognosis of mild acute pancreatitis through Dual Source-CT and Formal Methods. Computers in Biology and Medicine. 2025 Sep 1;196:110766.
12. Gowd YC. A Comparison Between Bisap Clinical Score and Balthazar Radiological Score in Assessing the Severity of Acute Pancreatitis–A Case Series Study (Master's thesis, Rajiv Gandhi University of Health Sciences (India)).
13. Singh P, Garg PK. Pathophysiological mechanisms in acute pancreatitis: Current understanding. Indian Journal of Gastroenterology. 2016 May;35(3):153-66.
14. Szeliga J, Jagielski M, Sobocki J, et al. Diagnostic and therapeutic management of severe acute pancreatitis. Evidence-based medicine (EBM) clinical practice guidelines. Wideochir Inne Tech Maloinwazyjne. 2025 Apr 9;20(1):1-29. doi: 10.20452/wiitm.2025.17941. PMID: 40547833; PMCID: PMC12177351.
15. Tsuchiya R, Kuroki T, Eguchi S. The pancreas from Aristotle to Galen. Pancreatology. 2015 Jan 1;15(1):2-7.
16. Fugazzola P, Podda M, Tian BW, Cobianchi L, Ansaloni L, Catena F. Clinical update on acute cholecystitis and biliary pancreatitis: between certainties and grey areas. EClinicalMedicine. 2024 Nov 1;77.
17. Hu JX, Zhao CF, Wang SL, et al. Acute pancreatitis: A review of diagnosis, severity prediction, and prognosis assessment from imaging technology, scoring systems, and artificial intelligence. World Journal of Gastroenterology. 2023 Oct 7;29(37):5268.
18. Metri A, Bush N, Singh VK. Predicting the severity of acute pancreatitis: Current approaches and future directions. Surg Open Sci. 2024 Mar 27;19:109-117. Doi: 10.1016/j.sopen.2024.03.012. PMID: 38650599; PMCID: PMC11033200.
19. Wu BU, Johannes RS, Sun X, Tabak Y, Conwell DL, Banks PA. The early prediction of mortality in acute pancreatitis: a large population-based study. Gut. 2008 Dec 1;57(12):1698-703.
20. Park JY, Jeon TJ, Ha TH, et al. Bedside index for severity in acute pancreatitis: comparison with other scoring systems in predicting severity and organ failure. Hepatobiliary & Pancreatic Diseases International. 2013 Dec 15;12(6):645-50.
21. Gao W, Yang HX, Ma CE. The value of BISAP score for predicting mortality and severity in acute pancreatitis: a systematic review and meta-analysis. PloS one. 2015 Jun 19;10(6):e0130412.
22. Stinton LM, Shaffer EA. Epidemiology of gallbladder disease: cholelithiasis and cancer. Gut and liver. 2012 Apr 17;6(2):172.
23. Dumbrava BD, Bass GA, Jumean A, Birido N, Corbally M, Pereira J, Biloslavo A, Zago M, Walsh TN. The Accuracy of Point-of-Care Ultrasound (POCUS) in Acute Gallbladder Disease. Diagnostics (Basel). 2023 Mar 26;13(7):1248. doi: 10.3390/diagnostics13071248. PMID: 37046466; PMCID: PMC10093186.
24. Yamamoto T, Horibe M, Sanui M, et al. Early detection of necrosis in low-enhanced pancreatic parenchyma using contrast-enhanced computed tomography was a better predictor of clinical outcomes than pancreatic inflammation: A multicentric cohort study of severe acute pancreatitis. Pancreatology. 2024 Sep 1;24(6):827-33.
25. Ceriani E, Schiavon R, La Cava et al. al. Point of care ultrasound: focus on evidence for a critical appraisal. European Journal of Internal Medicine.
26. Arif A, Jaleel F, Rashid K. Accuracy of BISAP score in prediction of severe acute pancreatitis. Pak J Med Sci. 2019 Jul-Aug;35(4):1008-1012. doi: 10.12669/pjms.35.4.1286. PMID: 31372133; PMCID: PMC6659069.
27. Bollen TL, Singh VK, Maurer R, et al. Comparative evaluation of the modified CT severity index and CT severity index in assessing the severity of acute pancreatitis. American Journal of Roentgenology. 2011 Aug;197(2):386-92.
28. Jingoniya NK, Yadav BL, Verma PK, Bansal S, Gupta S. Comparative evaluation of BISAP score and computed tomography severity index as a predictor for severity of acute pancreatitis. International Surgery Journal. 2022 Jan 29;9(2):421-5.
29. Papachristou GI, Muddana V, Yadav D, O'connell M, Sanders MK, Slivka A, Whitcomb DC. Comparison of BISAP, Ranson's, APACHE-II, and CTSI scores in predicting organ failure, complications, and mortality in acute pancreatitis. Official journal of the American College of Gastroenterology| ACG. 2010 Feb 1;105(2):435-41.
30. Singh VK, Wu BU, Bollen TL, Repas K, Maurer R, Mortele KJ, Banks PA. Early systemic inflammatory response syndrome is associated with severe acute pancreatitis. Clinical Gastroenterology and Hepatology. 2009 Nov 1;7(11):1247-51.
31. Landahl P, Ansari D, Andersson R. Severe acute pancreatitis: gut barrier failure, systemic inflammatory response, acute lung injury, and the role of the mesenteric lymph. Surgical infections. 2015 Dec 1;16(6):651-6.
32. Seif D, Perera P, Mailhot T, Riley D, Mandavia D. Bedside ultrasound in resuscitation and the rapid ultrasound in shock protocol. Critical Care Research and Practice. 2012;2012(1):503254.
33. Breakey N, Osterwalder J, Mathis G, Lehmann B, Sauter TC. Point-of-care ultrasound for rapid assessment and treatment of palliative care patients in acute medical settings. European journal of internal medicine. 2020 Nov 1;81:7-14.
34. Harshit Kumar A, Singh Griwan M. A comparison of APACHE II, BISAP, Ranson's score, and modified CTSI in predicting the severity of acute pancreatitis based on the 2012 revised Atlanta Classification. Gastroenterol Rep (Oxf). 2018 May;6(2):127-131. doi: 10.1093/gastro/gox029. Epub 2017 Jul 28. PMID: 29780601; PMCID: PMC5952961.
35. Shah VK, Gautam S, Siddiqui S, Nepal A, Gupta DK. BISAP Score as a Superior Predictor for Severe Acute Pancreatitis Compared to Ranson's Criteria: A cross-sectional study.
36. Kapadia NN, Siddiqui E. Bedside index (BISAP) v/s Ranson scores in predicting mortality and severity in patients with acute pancreatitis. JPMA. The Journal of the Pakistan Medical Association. 2021;71(8):1988.