UROPATHOGENS AND THEIR ANTIMICROBIAL SUSCEPTIBILITY PATTERN AT A TERTIARY CARE CENTRE OF JHARKHAND
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Keywords
Uropathogens, Gram negative, Gram positive, Bacteria, UTI, Antibiotic, susceptibility etc.
Abstract
- Urinary tract infections (UTIs) are among the most common bacterial infections, with an increasing prevalence of antimicrobial resistance (AMR). The rise in AMR among uropathogens is a growing concern, necessitating region-specific studies to guide appropriate treatment. This study aims to identify the predominant uropathogens and analyze their antimicrobial susceptibility patterns at a tertiary care center in Jharkhand.
Material and methods- A cross-sectional study was conducted on urine samples collected from 154 patients suspected of UTIs. Out of these, 122 cases were confirmed to have bacterial infection and standard microbiological methods were used for pathogen isolation and identification. Antimicrobial susceptibility testing was performed using the Kirby-Bauer disk diffusion method as per Clinical and Laboratory Standards Institute (CLSI) guidelines. A p-value of <0.05 was considered statistically significant.
Result- The present study reported 122 UTI positive cases with female dominance with maximum patients in the age group of 21–40years. History of DM and UTI showed a significant difference in positivity rates. Analysis of symptoms associated with UTI showed significant correlations. Escherichia coli were the most frequently isolated Gram-negative bacteria with Gram-positive bacteria being equally distributed. The antibiotic susceptibility pattern showed that among Gram-positive isolates, vancomycin, nitrofurantoin and gentamicin exhibited the highest sensitivity and among Gram-negative isolates, nitrofurantoin, meropenem, and piperacillin-tazobactam were the most effective antibiotics.
Conclusion- This study highlights the alarming rise in antimicrobial resistance among uropathogens in Jharkhand. Regular monitoring of susceptibility patterns is crucial for effective treatment and infection control strategies.
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Dr. Om Prakash Bharati
Assistant Professor, Department of Microbiology, Laxmi Chandravansi Medical College and Hospital, Palamu, India
Dr. Srishti Gunjan
Assistant Professor, Department of Microbiology, Laxmi Chandravansi Medical College and Hospital, Palamu, India
Dr. Anita Raj
Assistant Professor, Department of Microbiology, Laxmi Chandravansi Medical College and Hospital, Palamu, India
Dr. Vijay Kumar
Professor, Department of Community Medicine, Laxmi Chandravansi Medical College and Hospital, Palamu, India