UTILITY OF CAROTID INTIMA-MEDIA THICKNESS AS A PREDICTOR OF CORONARY ARTERY DISEASE
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Keywords
Cardiovascular risk, Carotid intima-media thickness (IMT), coronary artery disease (CAD), Ultrasonography
Abstract
Carotid intima-media thickness (IMT) is a recognized surrogate marker of systemic atherosclerosis and has been proposed as a predictor of coronary artery disease (CAD). This study assesses the utility of carotid IMT in predicting CAD in patients undergoing percutaneous coronary angiography.
Methods: A total of 50 patients were evaluated with Ultrasonography to measure carotid IMT. Patients were divided into CAD-positive (n=29) and CAD-negative (n=21) based on angiographic findings. Risk factors and IMT readings were analyzed comparatively.
Results: Raised IMT was significantly more frequent in CAD-positive patients (86.2%) than CAD-negative patients (9.5%). Hypertension and dyslipidemia were more prevalent in CAD-positive patients. IMT also correlated with the severity of coronary involvement.
Conclusion: Carotid IMT is strongly associated with the presence and severity of CAD and may serve as a reliable, non- invasive predictor in clinical assessments.
References
2. Berdah J., Luxereau P., Vahanian A., et al. Predictive factors of coronary lesions in aortic stenosis in adults. Archives des Maladies du Coeur et des Vaisseaux. 1988;81(1):33–39.
3. Bonow R. O., Carabello B., de Leon A. C., et al. ACC/AHA guidelines for the management of patients with valvular heart disease. Executive summary. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (committee on management of patients with valvular heart disease) The Journal of Heart Valve Disease. 1998;7(6):672–707.
4. Zhang Y., Guallar E., Qiao Y., Wasserman B. A. Is carotid intima-media thickness as predictive as other noninvasive techniques for the detection of coronary artery disease? Arteriosclerosis, Thrombosis, and Vascular Biology. 2014;34(7):1341–1345.
5. Balta S., Aparci M., Ozturk C., Unlu M., Celik T. Carotid intima media thickness can predict coronary artery disease. International Journal of Cardiology. 2015;201:p. 331.
6. Chang C. C., Chang M. L., Huang C. H., Chou P. C., Ong E. T., Chin C. H. Carotid intima-media thickness and plaque occurrence in predicting stable angiographic coronary artery disease. Clinical Interventions in Aging. 2013;8:1283–1288.
7. Timóteo A. T., Carmo M. M., Ferreira R. C. Carotid intima-media thickness and carotid plaques improves prediction of obstructive angiographic coronary artery disease in women. Angiology. 2013;64(1):57–63.
8. Burke G. L., Evans G. W., Riley W. A., et al. Arterial wall thickness is associated with prevalent cardiovascular disease in middle-aged adults. The Atherosclerosis Risk in Communities (ARIC) Study. Stroke. 1995;26(3):386–391.
9. Davis P. H., Dawson J. D., Riley W. A., Lauer R. M. Carotid intimal-medial thickness is related to cardiovascular risk factors measured from childhood through middle age: the Muscatine study. Circulation. 2001;104(23):2815–2819.
10. O'Leary D. H., Polak J. F., Kronmal R. A., Manolio T. A., Burke G. L., Wolfson SK Jr Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. The New England Journal of Medicine. 1999;340(1):14–22.
11. Silvestrini M., Cagnetti C., Pasqualetti P., et al. Carotid wall thickness and stroke risk in patients with asymptomatic internal carotid stenosis. Atherosclerosis. 2010;210(2):452–457.
12. Kirhmajer M. V., Banfic L., Vojkovic M., Strozzi M., Bulum J., Miovski Z. Correlation of femoral intima-media thickness and the severity of coronary artery disease. Angiology. 2011;62(2):134–139.
13. Grau M., Subirana I., Agis D., et al. Grosor intima-media carotideo en poblacion española: valores de referencia y asociacion con los factores de riesgo cardiovascular. Revista Española de Cardiología. 2012;65(12):1086–1093.
14. Evensen K., Sarvari S. I., Rønning O. M., Edvardsen T., Russell D. Carotid artery intima-media thickness is closely related to impaired left ventricular function in patients with coronary artery disease: a single-centre, blinded, non-randomized study. Cardiovascular Ultrasound. 2014;12(1):p. 39.
15. Stary H. C. Evolution and progression of atherosclerotic lesions in coronary arteries of children and young adults. Arteriosclerosis. 1989;9(1):119–132.
16. Hodis H. N., Mack W. J., LaBree L., et al. The role of carotid arterial intima-media thickness in predicting clinical coronary events. Annals of Internal Medicine. 1998;128(4):262–269.
17. Hulthe J., Wikstrand J., Emanuelsson H., Wiklund O., de Feyter P. J., Wendelhag I. Atherosclerotic changes in the carotid artery bulb as measured by B-mode ultrasound are associated with the extent of coronary atherosclerosis. Stroke. 1997;28(6):1189–1194.
18. Sun Y., Lin C. H., Lu C. J., Yip P. K., Chen R. C. Carotid atherosclerosis, intima media thickness and risk factors: an analysis of 1781 asymptomatic subjects in Taiwan. Atherosclerosis. 2002;164(1):89–94.
19. Ciccone M. M., Bilianou E., Balbarini A., et al. Task force on: ‘early markers of atherosclerosis: influence of age and sex’. Journal of Cardiovascular Medicine. 2013;14(10):757–766.
20. Ciccone M. M., Balbarini A., Teresa Porcelli M., et al. Carotid artery intima-media thickness: normal and percentile values in the Italian population (camp study) European Journal of Cardiovascular Prevention and Rehabilitation. 2011;18(4):650–655.
21. Simon A., Gariepy J., Chironi G., Megnien J. L., Levenson J. Intima-media thickness: a new tool for diagnosis and treatment of cardiovascular risk. Journal of Hypertension. 2002;20(2):159–169.
22. Simon A., Megnien J. L., Chironi G. The value of carotid intima-media thickness for predicting cardiovascular risk. Arteriosclerosis, Thrombosis, and Vascular Biology. 2010;30(2):182–185.
23. Lorenz MW, Markus HS, Bots ML, Rosvall M, Sitzer M. Prediction of clinical cardio vascular events with carotid intima-media thickness: a systematic review and meta-analysis. Circulation.2007;115(4):459-67.
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Dr. Bharti Abhishake
Resident, Department of Radiodiagnosis and Imaging, GMC, Srinagar, India
Dr. Naseer Ahmad Khan
Associate Professor, Department of Radiodiagnosis and Imaging, GMC, Srinagar, India
Dr. Bhumesh Kumar Angural
MD, Department of Medicine , GMC, Srinagar, India