ASSOCIATION OF LIPID PROFILE WITH CHOLESTEROSIS IN CHOLELITHIASIS PATIENTS - A HOSPITAL-BASED STUDY
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Keywords
Cholelithiasis, Cholesterosis, Lipid profile, Cholecystectomy
Abstract
The objective was to evaluate the prevalence of cholesterosis in cholelithiasis patients in semi urban population and to analyse various biochemical parameters of lipid profile in cholelithiasis patients and find its association and correlation with cholesterosis in cholelithiasis patients.
Materials and methods: Prospective study was carried out on 200 patients of cholelithiasis admitted in hospital. Based on the histopathological examination done, patient was grouped in two groups cholelithiasis with cholesterosis and without cholesterosis. Various parameters of lipid profile were studied in both the groups and association with cholelithiasis was analysed.
Statistical analysis: Data were methodically gathered and assembled and these observations were tabulated. Mean values of the variables were tested against normal ranges. A separate t-test was applied which showed p<0.05 which was considered statistically significant. Data was analysed using IBM SPSS statistics for windows version 29.
Results: out of 200 cholelithiasis patients 57 patients were having cholesterosis (47 were females and 10 were males) and rest 143 was having cholelithiasis without cholesterosis. Females were predominant in both the groups. Among the biochemical parameters, Total cholesterol, TG, LDL, VLDL, TC/HDL levels were significantly increased in subjects having cholelithiasis with cholesterosis as compared to cholelithiasis without cholesterosis. Moreover, HDL and HDL/LDL levels were decreased significantly in subjects having cholelithiasis with cholesterosis compared to cholelithiasis without cholesterosis.
Conclusion: The relationship between lipid profile and cholesterosis in cholelithiasis patients conclude that derangement in lipid profile is risk factor of cholesterosis in cholelithiasis patients. Early detection of deranged lipid profile will help in earlier diagnosis of cholesterosis and its management.
References
2. Ruhl, C. E., & Everhart, J. E. (2011). Gallstone disease is associated with increased mortality in the United States. Gastroenterology, 140(2), 508-516.
3. Bansal, A., Akhtar, M., & Bansal, A. K. (2014). A clinical study: prevalence and management of cholelithiasis. International Surgery Journal, 1(3), 134-139.
4. Selvi, T. R., Sinha, P., Subramaniam, P. M., Konapur, P. G., & Prabha, C. V. (2011). A clinicopathological study of cholecystitis with special reference to analysis of cholelithiasis. Int J Basic Med Sci, 2(2), 68-72.
5. Pak, M., & Lindseth, G. (2016). Risk factors for cholelithiasis. Gastroenterology Nursing, 39(4), 297-309.
6. Owen, C. C., & Bilhartz, L. E. (2003, October). Gallbladder polyps, cholesterolosis, adenomyomatosis, and acute acalculous cholecystitis. In Seminars in gastrointestinal disease (Vol. 14, No. 4, pp. 178-188).
7. Raraty, M. G., Sheel, A., & Neoptolemos, J. P. (2018). Epidemiology and etiology of acute biliary pancreatitis. The Pancreas: An Integrated Textbook of Basic Science, Medicine, and Surgery, 146-157.
8. Mohan, H., Punia, R. P. S., Dhawan, S. B., Ahal, S., & Sekhon, M. S. (2005). Morphological spectrum of gallstone disease in 1100 cholecystectomies in North India. Indian journal of surgery, 67(3).
9. Tanaja, J., Lopez, R. A., & Meer, J. M. (2017). Cholelithiasis.
10. Lammert, F., & Sauerbruch, T. (2005). Mechanisms of disease: the genetic epidemiology of gallbladder stones. Nature clinical practice Gastroenterology & hepatology, 2(9), 423-433.
11. Pottakkat, B., Vijayahari, R., Prakash, A., Singh, R. K., Behari, A., Kumar, A., ... & Saxena, R. (2010). Incidence, pattern and management of bile duct injuries during cholecystectomy: experience from a single center. Digestive surgery, 27(5), 375-379.
12. Cirillo, D. J., Wallace, R. B., Rodabough, R. J., Greenland, P., LaCroix, A. Z., Limacher, M. C., & Larson, J. C. (2005). Effect of estrogen therapy on gallbladder disease. Jama, 293(3), 330-339.
13. Moghaddam, T. G., Fakheri, H., Abdi, R., bavar Rostami, F. K., & Bari, Z. (2013). The incidence and outcome of pregnancy-related biliary sludge/stones and potential risk factors. Archives of Iranian medicine, 16(1), 0-0.
14. Fu, X., Gong, K., & Shao, X. (1995). The relationship between serum lipids, apolipoproteins level and bile lipids level, chemical type of stone. Zhonghua Yi Xue Za Zhi, 75(11), 656-9.
15. Han, T., Jiang, Z., Suo, G., & Zhang, S. (2000). Apolipoprotein B‐100 gene Xba I polymorphism and cholesterol gallstone disease. Clinical genetics, 57(4), 304-308.
16. Tang, W. H. (1996). Serum and bile lipid levels in patients with and without gallstones. Journal of gastroenterology, 31, 823-827.
17. Andreotti, G., Chen, J., Gao, Y. T., Rashid, A., Chang, S. C., Shen, M. C., ... & Hsing, A. W. (2008). Serum lipid levels and the risk of biliary tract cancers and biliary stones: a population‐based study in China. International journal of cancer, 122(10), 2322-2329.
18. Ivanchenkova, R. A., & Sharashkina, N. V. (2004). Heterogeneity of low-density lipoproteins in cholesterolosis of the gallbladder and cholelithiasis. Klinicheskaia meditsina, 82(10), 46-49.
19. Ivanchenkova, R. A., Sviridov, A. V., Ozerova, I. N., Perova, N. V., & Grachev, S. V. (2000). High-density lipoproteins in cholesterosis of the gall bladder. Klinicheskaia Meditsina, 78(4), 27-31.
20. Batajoo, H., & Hazra, N. K. (2013). Analysis of serum lipid profile in cholelithiasis patients.
21. Tandon, R. K., Saraya, A., Paul, S., & Kapur, B. M. L. (1996). Dietary habits of gallstone patients in Northern India: a case control study. Journal of clinical gastroenterology, 22(1), 23-27.
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Priya Anjali
Ph.D. Scholar, Department of Biochemistry, Teerthanker Mahaveer Medical College and Research Centre, Moradabad, U.P., India
Dr. Sana Alam
Professor, Department of Biochemistry, Hamdard Institute of Medical Science and Research, New Delhi, India
Dr. Sabina Khan
Professor, Department of Pathology, Hamdard Institute of Medical Science and Research, New Delhi, India
Shazia Bano
Tutor, Department of Biochemistry, Hamdard Institute of Medical Science and Research, New Delhi, India,
Dr. Sanjiv Bansal
Professor and Head, Department of Biochemistry, SGT University, Gurugram Haryana,
Dr. Tanish Baweja
Intern, Department of Medicine, Hamdard Institute of Medical Science and Research, New Delhi, India