ORTHODONTIC CONSIDERATIONS IN PATIENTS WITH HISTORY OF ORAL SQUAMOUS CELL CARCINOMA (OSCC) TREATMENT
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Keywords
Oral squamous cell carcinoma, orthodontic management, trismus, xerostomia, osteoradionecrosis, radiotherapy, post-cancer rehabilitation
Abstract
This study was intended to assess the orthodontic considerations and treatment possibility in patients who had previous history of treating oral squamous cell carcinoma (OSCC), with special emphasis on the obstacles caused by the post treatment consequences.
Methods: A cross-sectional study was carried out at Frontier Medical and Dental College, Abbottabad, between June 2023 and March 2024. 79 patients had undergone prior treatment of OSCC to be evaluated in terms of demographic factors, tumour, mode of treatment, post-treatment complications and orthodontic possibilities. Data collection was carried out using clinical examination and patient records. A statistical comparison was done in SPSS version 25, where a p-value <0.05 was termed as important
Results: Most patients were male (64.6%) and aged between 40–60 years. The tongue was the most common tumor site, and over half the patients had received surgery combined with chemoradiotherapy. Xerostomia (51.9%), trismus (35.4%), and periodontal compromise (41.8%) were the most frequent complications. Although 53.2% of patients required orthodontic treatment, only 39.2% were considered suitable for fixed appliances due to clinical limitations. Significant associations were observed between treatment history and orthodontic contraindications.
Conclusion: Orthodontic care in OSCC survivors is complex and must account for the long-term effects of oncologic treatment. Careful assessment and tailored treatment planning are essential to ensure safe and effective outcomes in this vulnerable population.
References
2. Alam, M.K., et al., A Systematic Review and Meta-Analysis of the Impact of Cancer and Its Treatment Protocol on the Success of Orthodontic Treatment. Cancers, 2023. 15(22): p. 5387.
3. Mitus-Kenig, M., et al., Quality of life in orthodontic cancer survivor patients—a prospective case–control study. International Journal of Environmental Research and Public Health, 2020. 17(16): p. 5824.
4. Ahmad, P., et al., Risk factors associated with the mortality rate of oral squamous cell carcinoma patients: A 10-year retrospective study. Medicine, 2021. 100(36): p. e27127.
5. Haverman, T.M., et al., Oral chronic graft-versus-host disease: what the general dental practitioner needs to know. The Journal of the American Dental Association, 2020. 151(11): p. 846-856.
6. Sami, A., et al., The role of the microbiome in oral squamous cell carcinoma with insight into the microbiome–treatment axis. International Journal of Molecular Sciences, 2020. 21(21): p. 8061.
7. Menditti, D., et al., Personalized medicine in oral oncology: Imaging methods and biological markers to support diagnosis of oral squamous cell carcinoma (OSCC): A narrative literature review. Journal of Personalized Medicine, 2023. 13(9): p. 1397.
8. Zettermann, P., et al., MALIGNANT TRANSFORMATION OF PROLIFERATIVE VERRUCOUS LEUKOPLAKIA INTO ORAL SQUAMOUS CELL CARCINOMA AFTER A LONG FOLLOW-UP: SERIES OF 3 CASES. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2022. 134(3): p. e116-e117.
9. Yusuf, C.T., et al., Ill-Fitting Dental Appliances and Oral Cancer: A Systematic Review and Case Report. Face, 2023. 4(3): p. 417-425.
10. Spoerl, S., et al., Statin use ameliorates survival in oral squamous cell carcinoma—data from a population-based cohort study applying propensity score matching. Biomedicines, 2023. 11(2): p. 369.
11. Saravana Murthy, P., et al., Evaluating the expression of microRNA‐15a‐5p and YAP1 gene in oral squamous cell carcinoma in comparison with normal tissue: A cross‐sectional study. Journal of Oral Pathology & Medicine, 2023. 52(7): p. 593-600.
12. Zheng, S., et al., RETRACTED ARTICLE: Dihydroartemisinin represses oral squamous cell carcinoma progression through downregulating mitochondrial calcium uniporter. Bioengineered, 2022. 13(1): p. 227-241.
13. Radermacher, A., et al., HLA-E and Its Soluble Form as Indicators of a Sex-Specific Immune Response in Patients with Oral Squamous Cell Carcinoma. International Journal of Molecular Sciences, 2023. 24(23): p. 16699.
14. Khan, A., R.A. Warraich, and S. Ali, Reconstruction of Intra-Oral Defects with Submental Artery Flap: A Comparison of pN+ and pN0 Oral Squamous Cell Carcinoma Patients. Pakistan Journal of Medical & Health Sciences, 2023. 17(09): p. 2-2.
15. Niu, Q., et al., Progress of nanomaterials-based photothermal therapy for oral squamous cell carcinoma. International Journal of Molecular Sciences, 2022. 23(18): p. 10428.
16. Costa, I.F.V.D.J., et al., INTRAMUCOSAL MELANOCYTIC NEVUS: CASE REPORT. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2022. 134(3): p. e109.
17. Cheng, H.-C., et al., Evaluation of factors associated with the risk stratification of survivorship for stage IV squamous cell carcinoma of the oral cavity: A 10-year retrospective study. Journal of the Chinese Medical Association, 2020. 83(5): p. 491-499.
18. Lu, Y., et al., The emerging role of exosomes in oral squamous cell carcinoma. Frontiers in cell and developmental biology, 2021. 9: p. 628103.
19. Maqsood, A., et al., Expression of CD34 and α-SMA markers in oral squamous cell carcinoma differentiation. A histological and histo-chemical study. International Journal of Environmental Research and Public Health, 2021. 18(1): p. 192.
20. Lopes, A.D.A.L.B., et al., SQUAMOUS CELL CARCINOMA IN A NONSMOKER YOUNG PATIENT: A CASE REPORT. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2022. 134(3): p. e109.
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Munawar Manzoor Ali
Associate Professor, Department Of Orthodontics, Azra Naheed Dental College, Superior University, Lahore, Pakistan.
Gulsana Hashmi
Assistant Professor, Department Of Orthodontics, Azra Naheed Dental College, Superior University, Lahore, Pakistan.
Taimur Khan
Associate Professor, Department Of Orthodontics, Frontier Medical And Dental College, Abbottabad, Pakistan.
Usman Yousaf
Associate Professor, Department Of Orthodontics, University College Of Medicine & Dentistry, The University Of Lahore, Lahore, Pakistan.
Junaid Dayar
Assistant Professor, Department Of Orthodontics, Institute Of Dentistry, Cmh Lahore Medical College, Lahore, Pakistan.
Asma Rafi Chaudhry
Associate Professor, Department Of Orthodontics, Institute Of Dentistry, Cmh Lahore Medical College, Lahore, Pakistan.