FREQUENCY OF HYPOTHYROIDISM AMONG HYPONATREMIC PATIENTS
Main Article Content
Keywords
Hyponatremia, hypothyroidism, thyroid function, electrolyte imbalance, euvolemic hyponatremia.
Abstract
Introduction: Hyponatremia is a fairly common electrolyte disorder which is frequently associated with endocrine conditions such as hypothyroidism but whose direct causal relationship is far from clear. They are relevant because their association must be understood for effective diagnosis and management.
Objective: The aim of the study was to determine the frequency of hypothyroidism among hyponatremic patients in a hospital in Pakistan.
Materials and Method: The study done at Aga Khan University Hospital Karachi from February, 2024 to July, 2024 is a descriptive cross-sectional one. Those with known hyponatremia causes were excluded, and patients with serum sodium <135 mmol. Hypothyroidism was assessed by thyroid function tests, and the data were described through descriptive statistics.
Results: Of 150 hyponatremic patients (58.7% male, mean age 52.4 years), 22.7% had hypothyroidism (16.7% overt, 6.0% subclinical). Hypothyroid patients were older (mean age 58.3 years) and more likely female (27.4%). Euvolemic hyponatremia was predominant (70.6%) in hypothyroid patients, with a significant association (p < 0.05).
Conclusion: Hypothyroidism is a notable contributor to hyponatremia, particularly in older females. Routine thyroid screening is recommended for hyponatremic patients to ensure timely diagnosis and treatment.
References
2- Emektar, E., Olcay, H.Ö., Şahin, A., Yaygın, H.E. and Çevik, Y., 2024. Incidence of Hyponatremia in Geriatric Patients Presenting to the Emergency Department with Headache.
3- Khidir, R.J.Y., Ibrahim, B.A.Y., Adam, M.H.M., Hassan, R.M.E., Fedail, A.S.S., Abdulhamid, R.O. and Mohamed, S.O.O., 2022. Prevalence and outcomes of hyponatremia among COVID-19 patients: a systematic review and meta-analysis. International Journal of Health Sciences, 16(5), p.69.
4- Chen, J., 2023. Is there a causal relationship between hypothyroidism and hyponatremia?. Therapeutic Advances in Endocrinology and Metabolism, 14, p.20420188231180983.
5- Alqahtani, H.A., Almagsoodi, A.A., Alshamrani, N.D., Almalki, T.J., Sumaili, A.M., Alshamrani, N. and Sumaili, A., 2021. Common electrolyte and metabolic abnormalities among thyroid patients. Cureus, 13(5).
6- Seethapathy, H., Rusibamayila, N., Chute, D.F., Lee, M., Strohbehn, I., Zubiri, L., Faje, A.T., Reynolds, K.L., Jhaveri, K.D. and Sise, M.E., 2021. Hyponatremia and other electrolyte abnormalities in patients receiving immune checkpoint inhibitors. Nephrology Dialysis Transplantation, 36(12), pp.2241-2247.
7- Yamamoto, Y., Ohta, A., Usui, N., Imai, K., Kagawa, Y. and Takahashi, Y., 2023. Incidence trends and risk factors for hyponatremia in epilepsy patients: a large-scale real-world data study. Heliyon, 9(8).
8- Cao, J.J., Yun, C.H., Xiao, J., Liu, Y., Wei, W. and Zhang, W., 2021. Analysis of the incidence and influencing factors of hyponatremia before 131I treatment of differentiated thyroid carcinoma. World Journal of Clinical Cases, 9(36), p.11173.
9- Ioannou, P., Panagiotakis, S., Tsagkaraki, E., Tsioutis, C., Fragkiadakis, K., Gikas, A. and Filippatos, T.D., 2021. Increased mortality in elderly patients admitted with hyponatremia: a prospective cohort study. Journal of Clinical Medicine, 10(14), p.3059.
10- Kumar, A., Ghosh, M. and Jacob, J.J., 2021. Prevalence of adrenal insufficiency among patients with euvolemic hyponatremia. Endocrine Connections, 10(12), pp.1623-1631.
11- Kumar, A., Singh, J., Hashmat, O., Ameet, P., Budhrani, N. and Sher, K., 2021. Frequency of hyponatremia in patients of tuberculosis bacterial meningitis in a tertiary care hospital. Cureus, 13(3).
12- Kumar, A., Singh, J., Hashmat, O., Ameet, P., Budhrani, N. and Sher, K., 2021. Frequency of hyponatremia in patients of tuberculosis bacterial meningitis in a tertiary care hospital. Cureus, 13(3).
13- Aldahash, R., Binsalih, S., Masuadi, E., Alashaikh, F., Alhamadh, M., Alsugair, S., Alhuntushi, A. and Alkharashi, Y., 2021. Association between thyroid abnormalities & glycemic control among adults with type 1 Diabetes Mellitus: Cross-sectional study in Saudi Arabia. Journal of Health Informatics in Developing Countries, 15(2).
14- Lee, G., Steinberg, S., Shahid, S., Ezenduka, E. and Flores, E., 2025. Hypothyroidism Associated Hyponatremia, A Complicated Presentation.
15- Lin, K., Lu, L., Pei, Z., Mu, S., Huang, S. and Wang, S., 2022. Predictive factors for delayed hyponatremia after transsphenoidal surgery in patients with pituitary adenomas. Endocrine Connections, 11(1).
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Dr Muhammad Ayaz Khan
District Medical Officer, Department of Public Health, Al-Khidmat Hospital Charsadda KPK, Pakistan
Dr Hafiza Amna Benazir
Senior House Officer, Department of General Internal Medicine, Ennis General Hospital Ireland
Dr Amna Khalid
Medical Assistant in Christus Santa Rosa Hospital New Braunfels, Texas
Dr Niaz Ahmed
Professor, Department Medicine, Shaheed Mohtarma Benazir Bhutto Medical College Lyari Karachi and Sindh Government Lyari General Hospital, Pakistan
Dr Dial Das
Associate Professor, Department of Pharmacology, Chandka Medical College, Larkana Sindh, Pakistan
Dr Momin Khan
Associate Professor, Medicine Department, Saidu Group of Teaching Hospital, Pakistan