EFFICACY OF MESOTHERAPY WITH VITAMIN C IN PATIENTS OF MELASMA WITH FITZPATRICK SKIN TYPE IV & V
Main Article Content
Keywords
Mesotherpay, Vitamin C, Melasma
Abstract
Melasma is a skin disorder that is managed through various topical applications. But still dermatologists are in search for a better management plan.
OBJECTIVE:
To determine the outcome of mesotherapy with topical vitamin C in patients with melasma in Fitzpatrick skin type IV & V.
Study Design: Quasi Experimental Study.
Duration of Study: 02 April, 2022 to 02 October, 2022.
Data Collection Procedure:
Data was collected from patients presenting in OPD of Dermatology Department, Sharif medical city hospital, Lahore fulfilling the selection criteria. After approval from the ethical committee of hospital, an informed consent was obtained to include their data in the study. Melasma Area and Severity Index score(MASI) was calculated before first session and after end of third session by using Wood’s light. Microneedling was carried out in vertical, horizontal and both diagonal directions for about ten passes in each direction or till pinpoint bleeding occurs. Pure vitamin C of healer’s pharma was applied over all affected area. At the end of the study, photographs were recorded again to compare with baseline photographs, and outcome calculated on a pre-designed proforma. Data entry and analysis was done by using SPSS 23.
Results: Mean age was 32.50±4.79 years. Majority of the cases were female 84(79.2%). Paired sample T test revealed that mean difference of the pre and post treatment MASI score was 3.83±1.86 with a significant difference.
Conclusion: Mesotherapy with topical vitamin C is effective method in terms of the reduction of the mean MASI score.
References
2. Kaleem S, Ghafoor R, Khan S. Comparison of efficacy of tranexamic acid mesotherapy versus 0.9% normal saline for melasma: a split-face study in a tertiary care hospital of Karachi. Pak J Med Sci. 2020 Jul;36(5):930.
3. Iraji F, Nasimi M, Asilian A, Faghihi G, Mozafarpoor S, Hafezi H. Efficacy of mesotherapy with tranexamic acid and ascorbic acid with and without glutathione in treatment of melasma: a split face comparative trial. J Cosmet Dermatol. 2019 Oct;18(5):1416–21.
4. Jawaid K, Shahid M, Tahir K, Ali N, Tariq A, Hussain A. Frequency of anxiety and depression in patients with melasma. J Pak Assoc Dermatol. 2020 Aug 7;30(1):81–5.
5. Ehsan I, Aman S, Nadeem M, Kazmi A. Efficacy of Q-switched Nd:YAG laser 1,064 nm for the treatment of melasma. J Pak Assoc Dermatol. 2020 Aug 7;30(1):106–10.
6. Ismail ES, Patsatsi A, Abd el‐Maged WM, Nada EE. Efficacy of microneedling with topical vitamin C in the treatment of melasma. J Cosmet Dermatol. 2019 Oct;18(5):1342–7.
7. Ustuner P, Balevi A, Ozdemir M. A split-face, investigator-blinded comparative study on the efficacy and safety of Q-switched Nd:YAG laser plus microneedling with vitamin C versus Q-switched Nd:YAG laser for the treatment of recalcitrant melasma. J Cosmet Laser Ther. 2017 Oct 3;19(7):383–90.
8. Sheth VM, Pandya AG. Melasma: a comprehensive update: part I. J Am Acad Dermatol. 2011;65(4):689–97.
9. Ogbechie-Godec OA, Elbuluk N. Melasma: an up-to-date comprehensive review. Dermatol Ther. 2017 Sep;7(3):305–18.
10. Trivedi MK, Yang FC, Cho BK. A review of laser and light therapy in melasma. Int J Womens Dermatol. 2017 Mar 1;3(1):11–20.
11. Kaur A, Bhalla M. Topical tranexamic acid with microneedling in melasma. Acta Sci Med Sci. 2019;3(4):124–6.
12. Trivedi MK, Yang FC, Cho BK. A review of laser and light therapy in melasma. Int J Womens Dermatol. 2017 Mar 1;3(1):11–20.
13. Amega Ade A, Miot LD, Bonfietti C, Gige TC, Marques ME, Miot HA. Clinical patterns and epidemiological characteristics of facial melasma in Brazilian women. J Eur Acad Dermatol Venereol. 2013;27(2):151–6.
14. Hexsel D, Lacerda DA, Cavalcante AS, Machado Filho CA, Kalil CL, Ayres EL, et al. Epidemiology of melasma in Brazilian patients: a multicenter study. Int J Dermatol. 2014;53(4):440–4.
15. M.K.D. Santos, M.J. Doria-Ruiz and M. Buenviaje-Beloso. Efficacy of Micro-Needling with Topical Vitamin C and E Serum Versus Micro-Needling Alone in Recalcitrant Facial Melasma. AsianJournal of Dermatology, 2022;14: 1-9.
16. Ismail ES, Patsatsi A, Abd el‐ Maged WM, Nada EE. Efficacy of microneedling with topical vitamin C in the treatment of melasma. Journal of cosmetic dermatology. 2019 Oct;18(5):1342-7.
17. Menon A, Eram H, Kamath PR, Goel S, Babu AM. A split-face comparative study of safety and efficacy of microneedling with tranexamic acid versus microneedling with vitamin C in the treatment of melasma. Indian Dermatol Online J. 2020 Jan 1;11(1):41–5.
18. Gul S, Gardezi SA, Arshad A, Ahmad TJ, Aman S, Shaukat S. Microneedling with topical ascorbic acid in the treatment of melasma. Journal of Pakistan Association of Dermatologists. 2023 Jul 2;33(2):547-52.
19. Iraji F, Nasimi M, Asilian A, Faghihi G, Mozafarpoor S, Hafezi H. Efficacy of mesotherapy with tranexamic acid and ascorbic acid with and without glutathione in treatment of melasma: A split face comparative trial. Journal of cosmetic dermatology. 2019 Oct;18(5):1416-21.
20. Fahim M, Khoso H, Khan J, Gul H, Bakhtiar R. Efficacy of Intradermal Tranexamic acid versus topical 5% Magnesium ascorbyl phosphate in the treatment of melasma: A head-to-head comparison. Journal of Pakistan Association of Dermatologists. 2023 Oct 12;33(4):1412-20.
Article Sidebar
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Dr Ayesha Rehman
MBBS, FCPS Dermatology, Sharif Medical City Hospital, Pakistan
Dr Ammara Azeem
MBBS, FCPS Dermatology, Senior Registrar, Abwa Hospital and Research Center, Pakistan
Dr Mehwish
MBBS, Medical Officer, Abwa Hospital and Research Center, Pakistan
Dr Uzma Ahsan
MBBS, FCPS Dermatology, Professor, Sharif Medical City Hospital, Paksitan
Dr Sarah Khan
MBBS, FCPS Dermatology, Sharif Medical City Hospital, Pakistan