CORRELATION BETWEEN SERUM MICRONUTRIENTS AND PSYCHOLOGICAL WELLBEING IN PHASE 1ST MBBS STUDENTS

Main Article Content

Dr. Deva Pragna Prashanthi M.D.
Dr. Shivakrishna Gouroju PhD
Dr. Vineela Rani N.V.N. Chowdary M.D
Dr. Bandaru Aruna Kumari M.D.

Keywords

Phase 1st MBBS, Psychological wellbeing and Micronutrients.

Abstract

Introduction/Background: There is limited literature assessing the combined biochemical and psychological profile of MBBS students. This study seeks to fill that gap by aims to assess the correlation between serum micronutrient levels (magnesium, iron, vit D3, B12, and hemoglobin) and psychological distress (e.g., depression, anxiety, stress) in Phase 1st MBBS students.


Materials and Method: This cross-sectional study was conducted after taking informed consent from the 100 participants (phase 1st MBBS students) a questionnaire was given to evaluate their psychological wellbeing and 5ml venous blood sample was collected in plain tube, analysed for serum micronutrients like magnesium, Iron, Vit D3, B12 and Hemoglobin.


Results and conclusion: The mean ± SD values of magnesium were 1.79 ±0.53, iron was 83.20± 29.62, Vit D3 was 14.64 ± 6.58, Vit B12 was 220.77±45.30 and Hemoglobin was 11.93 ±2.65.  Psycological state was evaluated using mental illness assessment score ranging from 0 to 26.  Students with low serum levels of iron, Vit B12 and Hemoglobin were presented with increased symptoms of depression, anxiety, fatigue, impaired concentration and sleep. Deficiency in magnesium were presented with mood changes and cognitive performance. Deficiency in Vit D3 were presented with mood changes, fatigue and loss of interest in their hobbies. Because of this psychological distress showing effect on academic attendance. This study was showing a strong positive correlation between attendance and psychological score (r = 0.90), with significantly reduced attendance in the severe group (76.77%) compared to the normal group (94.93%). This study will be helpful to evaluate the mental status and in correcting their nutritional deficiency by supplementation of micronutrients and also useful in improving their academic performance.

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References

1. Tardy AL, Pouteau E, Marquez D, Yilmaz C, Scholey A. Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence. Nutrients. 2020 Jan 16;12(1):228.
2. Khanna P, Chattu VK, Aeri BT. Nutritional Aspects of Depression in Adolescents - A Systematic Review. Int J Prev Med. 2019:3;10:42.
3. Kris-Etherton PM, Petersen KS, Hibbeln JR, Hurley D, Kolick V, Peoples S, et.al. Nutrition and behavioral health disorders: depression and anxiety. Nutr Rev. 2021:11;79(3):247-60.
4. Mrozek W, Socha J, Sidorowicz K, Skrok A, Syrytczyk A, Piątkowska-Chmiel I, etal. Pathogenesis and treatment of depression: Role of diet in prevention and therapy. Nutrition. 2023;115:112143.
5. Zielińska M, Łuszczki E, Dereń K. Dietary Nutrient Deficiencies and Risk of Depression (Review Article 2018-2023). Nutrients. 2023 May 23;15(11):2433.
6. Raja S, Balasubramanian G, Jamuna Rani R. Prevalence of depression, anxiety and stress among private medical college students in South India: A cross-sectional study. J Educ Health Promot. 2022 Nov 26;11:373.
7. Kumar SG, Kattimani S, Sarkar S, Kar SS. Prevalence of depression and its relation to stress level among medical students in Puducherry, India. Ind Psychiatry J. 2017 Jan-Jun;26(1):86-90.
8. Kamboj G. N, Bhartiya S. Prevalence of stress, anxiety and depression in undergraduate medical students: a cross sectional study. Int J Community Med Public Health. 2021;8(3):1471-5.
9. Taneja, Neha; Sachdeva, Sandeep; Dwivedi, Nidhi. Assessment of Depression, Anxiety, and Stress among Medical Students Enrolled in a Medical College of New Delhi, India. Indian Journal of Social Psychiatry. 2018:34(2):p 157-62.
10. Barker ME, Blain RJ, Russell JM. The influence of academic examinations on energy and nutrient intake in male university students. Nutr J. 2015;14:98.
11. Rana G, Abraham RA, Sachdev HS, Nair KM, Kumar GT, Agarwal PK et.al. Prevalence and Correlates of Vitamin D Deficiency Among Children and Adolescents From a Nationally Representative Survey in India. Indian Pediatr. 2023;60(3):202-6.
12. Srivani S, Nutakki S, Chowdeswari N, Swathi V, Sreya. Comparative Study of Vitamin B12 and Folic Acid Levels among Vegetarian andNon Vegetarian Medical Students. Biochem Physiol. 2023:12: 410.
13. Warner MJ, Kamran MT. Iron Deficiency Anemia. [Updated 2023 Aug 7]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK448065/
14. Cuciureanu MD, Vink R. Magnesium and stress. In: Vink R, Nechifor M, editors. Magnesium in the Central Nervous System [Internet]. Adelaide (AU): University of Adelaide Press; 2011.
15. Javed, A. , Sharma, T. , & Hazari, R. S. (2017). Evaluation of Prevalence of Anemia and Its Sociodemographic Correlation among Undergraduate Medical College Students - A Cross Sectional Study. World Journal of Nutrition and Health, 5(2), 57-61.
16. Ali AM, Alkhamees AA, Hori H, Kim Y, Kunugi H. The Depression Anxiety Stress Scale 21: Development and Validation of the Depression Anxiety Stress Scale 8-Item in Psychiatric Patients and the General Public for Easier Mental Health Measurement in a Post COVID-19 World. Int J Environ Res Public Health. 2021 Sep 27;18(19):10142.
17. Wu Q, Ren Q, Meng J, Gao WJ, Chang YZ. Brain Iron Homeostasis and Mental Disorders. Antioxidants (Basel). 2023 Nov 13;12(11):1997.
18. Oraibi O, Somaili M, Jaawna E,Alfaraj S, Majhali J, Zuqayl A, et al. Investigating thelink between vitamin d deficiency and depression andanxiety in medical students at Jazan university: across-sectional study. Int J Community Med PublicHealth 2024;11.
19. Mikkelsen K, Stojanovska L, Apostolopoulos V. The Effects of Vitamin B in Depression. Curr Med Chem. 2016;23(38):4317-4337.
20. Hariz A, Bhattacharya PT. Megaloblastic Anemia. [Updated 2023 Apr 3]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK537254/
21. Ankar A, Kumar A. Vitamin B12 Deficiency. [Updated 2024 Sep 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK441923/