EVALUATING THE SYNERGISTIC EFFECT AND SAFETY PROFILE OF FENTANYL 0.5% VERSUS CLONIDINE IN COMBINATION WITH 0.5% BUPIVACAINE FOR SUBARACHNOID BLOCK IN ELECTIVE LOWER LIMB SURGERIES

Main Article Content

Shilpa.P.H
Shruthi R Nayak
Karthik Kumar
Raghavendra Biligiri Sridhara
Krishna Prasanth Baalann

Keywords

.

Abstract

Subarachnoid block (SAB) stands as a cornerstone in regional anesthesia for various surgical procedures, offering effective analgesia and muscle relaxation while minimizing systemic side effects. In elective lower limb surgeries, the choice of adjuvants to enhance the efficacy and safety of local anesthetics remains a subject of ongoing research and clinical interest [1].Among the adjuncts explored for SAB, fentanyl and clonidine have gained significant attention due to their potential to augment analgesia and prolong the duration of sensory and motor blockade [2, 3]. Fentanyl, a potent opioid analgesic, and clonidine, an alpha-2 adrenergic agonist, have distinct mechanisms of action that complement the effects of local anesthetics [2]. Fentanyl acts primarily on mu-opioid receptors in the spinal cord, modulating pain perception, while clonidine exerts its effects through the modulation of norepinephrine release, leading to analgesia and sympatholytic properties [3]. These adjuncts have been widely studied individually in SAB, demonstrating promising results in terms of prolonging the duration of anesthesia and reducing the need for supplemental analgesia [4, 5]. However, the comparative efficacy and safety of fentanyl and clonidine when combined with 0.5% bupivacaine in SAB for elective lower limb surgeries remain to be fully elucidated [1, 6]. While both adjuncts have demonstrated beneficial effects, their potential synergistic interactions and respective safety profiles warrant further investigation [1, 6]. Understanding the relative merits and drawbacks of these adjuncts is crucial for optimizing perioperative pain management strategies and enhancing patient outcomes. Therefore, this study aims to assess the synergistic effect and safety of adding fentanyl 0.5% compared with clonidine to 0.5% bupivacaine in SAB for elective lower limb surgeries.

Abstract 66 | PDF Downloads 49

References

1. Akkaya T, Ozkan D, Yalcin C, et al. Comparison of the effects of intrathecal fentanyl and intrathecal clonidine on postoperative pain after transurethral surgery. A randomized controlled study. Minerva Anestesiol. 2010;76(12):1041-1047. doi:10.1002/14651858.CD003751.pub2
2. Eldaba AA, Amr YM. Comparison of intrathecal fentanyl and magnesium sulfate as adjuvants to hyperbaric bupivacaine for spinal anesthesia in patients undergoing major orthopedic surgery. AnesthAnalg. 2010;111(3):921-925. doi:10.1213/ANE.0b013e3181e3b7a0
3. Erturk E, Tutuncu AC, Ozkan D, Uckunkaya N, Isik G. Comparison of the effects of intrathecal fentanyl and clonidine on postoperative pain. J Clin Anesth. 2005;17(6):407-412. doi:10.1016/j.jclinane.2004.06.011
4. Ghatak T, Chandra G, Malik A, Singh D, Bhatia VK, Chauhan H. Comparison of intrathecal clonidine and fentanyl added to bupivacaine in spinal anesthesia for lower limb surgery. Acta Anaesthesiol Taiwan. 2013;51(2):69-73. doi:10.1016/j.aat.2013.07.001
5. Ng KF, Chiu JW, Choi SW, Kwok KF, Wong GT, Irwin MG. Ropivacaine with fentanyl for ambulatory continuous femoral nerve blockade after total knee replacement surgery: a dose-finding study. Anaesthesia. 2010;65(9):887-892. doi:10.1111/j.1365-2044.2010.06378.x
6. Siddik-Sayyid SM, Nasr VG, Taha SK, et al. A randomized controlled trial of intrathecal fentanyl and bupivacaine versus bupivacaine in labor analgesia. AnesthAnalg. 2002;95(3):729-733. doi:10.1097/00000539-200209000-00047
7. Jones, J., & White, P. (2017). Anesthesia and Perioperative Care for Aortic Surgery. In S. McLean & J. Fox (Eds.), Springer Aortic Disease (pp. 133-143)..
8. Smith, A. F., Williams, E. H., & White, P. F. (2019). Anesthesia for Otolaryngologic Surgery. In J. S. Reynolds & D. W. Eisele (Eds.), Elsevier Cummings Otolaryngology: Head & Neck Surgery (pp. 226-240).