Evaluation of the Efficacy of Platelet Rich Fibrin with Bone Graft in the Reconstruction of Unilateral Alveolar Cleft

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Enas Abdulsattar Abdulmaged
Mohammed Oday Falih


bone graft, alveolar cleft, alloplastic material, autogenous bone graft, platelet rich fibrin.


Background: Alveolar cleft grafting aims to stabilize and restore the continuity of the maxillary arch, provide support for tooth eruption, eliminate oronasal fistulas, and improve the aesthetic outcome. Alveolar cleft reconstruction using alloplastic material has been proposed as a way to speed up surgery, provide a significant amount of bone, and eliminate the requirement for a donor site. Platelet-rich fibrin (PRF), consider an abundant source of autologous cytokines and growth factors, that enable bone regeneration and soft tissue maturation.

Patients and Methods: This research was performed at the Department of Oral and Maxillofacial Surgery at Al-Wasity Teaching Hospital in Iraq, from (November 2020 and June 2022). Twenty patients with a unilateral alveolar cleft, aged 7 to 13, were involved in this study. Two equal groups of patients were created; group I contained ten patients; alveolar cleft reconstructed by the alloplastic bone substitute (QualyBone BCP) with platelet rich fibrin (PRF). While group II contained ten patients, was grafted with an alloplastic bone substitute (QualyBone BCP) only. Cone-beam computerized tomography was used to assess how PRF affects bone healing, as well as the height, density, and bone continuity in both groups.

Results: Six months postoperatively, the height and density of bone growth show a significant difference between the two groups. At the same time interval, the new bone formation in group I was denser and higher than in group II. also, good bone continuity was observed in all patients.

Conclusion: platelet rich fibrin effect on vascularization and regeneration of bony defects. Also, preserve the bone height and increased bone density in a six months period.

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