INFLAMMATORY MARKERS AND PATHOGENESIS OF OSSIFICATION OF THE POSTERIOR LONGITUDINAL LIGAMENT (OPLL): A PROSPECTIVE STUDY
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Keywords
Ossification of the posterior longitudinal ligament (OPLL), Inflammation, hs-CRP, ESR, Spinal cord compression.
Abstract
Ossification of the posterior longitudinal ligament (OPLL) is a condition characterized by ectopic bone formation within the spinal ligaments, leading to spinal canal narrowing and neurological impairment. This prospective study aimed to evaluate the potential role of inflammation in OPLL by analyzing serum high-sensitivity C-reactive protein (hs-CRP) and erythrocyte sedimentation rate (ESR) levels in OPLL patients and comparing them with control subjects. The study included 95 OPLL patients and 100 controls, with biomarker analysis conducted using immunonephelometric assays. Results showed significantly elevated hs-CRP and ESR levels in OPLL patients compared to controls, with even higher levels in the OPLL progression group. These findings suggest that inflammation may contribute to OPLL pathogenesis and progression, supporting the potential role of anti-inflammatory therapy in its management. Further research is required to establish the precise mechanisms linking inflammation to OPLL development.
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Dr. Mote Srikanth
Assistant Professor, Department of General Medicine, Sri Lakshmi Narayana Institute of Medical Sciences & Hospital, Osudu, Agaram Village, Koodapakkam Post, Puducherry - 605502