ASSESSMENT OF THE ANALYTICAL PERFORMANCE OF POINT-OF-CARE TESTING DEVICES FOR CARDIAC BIOMARKERS
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Keywords
Point-of-Care Testing (POCT); Troponin; CK-MB; BNP; Cardiac Biomarkers; Diagnostic
Abstract
This study evaluated the diagnostic accuracy and agreement of point-of-care testing (POCT) for cardiac biomarkers—Troponin, CK-MB, and BNP/NT-proBNP—compared to standard laboratory methods in 203 patients with cardiac symptoms. POCT showed near-perfect correlation with lab results for Troponin (r = 0.999) and CK-MB (r = 0.989), with minimal measurement bias and consistent performance across devices and genders. While overall diagnostic accuracy was high (91%) and specificity reached 100%, sensitivity was moderate (54%), indicating POCT should complement, not replace, comprehensive clinical assessment. These findings support POCT’s role in fast-paced clinical settings, while highlighting the need for cautious interpretation and further validation..
References
[2] P. Ponikowski et al., "2016 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure: The task force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) developed with the special contribution of the Heart Failure Association (HFA) of the ESC", Eur. Heart J., vol. 37, pp. 2129–2200, 2016.
[3] B. Ziaeian and G. C. Fonarow, "Epidemiology and aetiology of heart failure", Nature Rev. Cardiology, vol. 13, no. 6, pp. 368–378, 2016.
[4] J. Hu et al., "Portable microfluidic and smartphone-based devices for monitoring of cardiovascular diseases at the point of care", Biotechnology Adv., vol. 34, pp. 305–320, 2016.
[5] M. Shephard, A Practical Guide to Global Point-of-Care Testing.
[6] S. L. Chow et al., "Role of biomarkers for the prevention assessment and management of heart failure: A scientific statement from the American Heart Association", Circulation, vol. 135, no. 22, pp. e1054–e1091, 2017.
[7] W. H. W. Tang et al., "National academy of clinical biochemistry laboratory medicine practice guidelines: Clinical utilization of cardiac biomarker testing in heart failure", Circulation, vol. 116, no. 5, pp. e99–109, 2007.
[8] S. Boonkaew et al., "Electrochemical paper-based analytical device for multiplexed, point-of-care detection of cardiovascular disease biomarkers", Sensors and Actuators B: Chemical, vol. 330, 129336, 2021. https://doi.org/10.1016/j.snb.2020.129336
[9] P. Collinson et al., "Cardiac troponin measurement at the point of care: Educational recommendations on analytical and clinical aspects by the IFCC Committee on Clinical Applications of Cardiac Bio-Markers (IFCC C-CB)", Clinical Chemistry and Laboratory Medicine, 2023. https://doi.org/10.1515/cclm-2022-0797
[10] R. D. Crapnell et al., "Electroanalytical point-of-care detection of gold standard and emerging cardiac biomarkers for stratification and monitoring in intensive care medicine – a review", Analytical and Bioanalytical Chemistry, vol. 414, Article 142, 2022. https://doi.org/10.1007/s00216-022-03929-6
[11] A. Clerico et al., "High-sensitivity Point of Care Testing (POCT) methods for cardiac troponins: Analytical features and clinical relevance", Clinical Chemistry and Laboratory Medicine, 2023 (Preprint/In press).
[12] International Federation of Clinical Chemistry and Laboratory Medicine (IFCC), Committee on Clinical Applications of Cardiac Bio-Markers (C-CB), "Educational recommendations on point-of-care cardiac troponin testing", Clinical Chemistry and Laboratory Medicine, 2023. https://doi.org/10.1515/cclm-2022-0797
[13] C. S. Henry et al., "Multiplexed electrochemical detection of CRP, cTnI, and PCT using a paper-based analytical device", Sensors and Actuators B: Chemical, vol. 330, 129336, 2021.
[14] A. Clerico et al., "Implementation and clinical utility of hs-cTnI Point-of-Care Testing for NSTEMI detection: Analytical and practical insights", SIBioC–ELAS Consensus Paper, Italian Society of Clinical Biochemistry, 2023.
[15] "Troponin-1, CK-MB, D-DIMER, AND NT-proBNP LEVELS BEFORE AND AFTER TWO DIFFERENT ANESTHESIA PROTOCOLS IN DOG", Assiut Veterinary Medical Journal, vol. 69, issue 177, pp. 48–57, April 2023. DOI: 10.21608/avmj.2023.177891.1105
[16] S. Hendricks et al., "Higher BNP/NT-pro BNP levels stratify prognosis equally well in patients with and without heart failure: a meta-analysis", ESC Heart Failure, published online 29 June 2022. https://doi.org/10.1002/ehf2.14019
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Abdulmajeed Asiri
lab Specialist, 12aa0040215, Armed Forces Hospital,
Abdulaziz Mohammed Alsharaef
laboratory Department - Armed Forces Hospital South Region
Omar Al Mutawa
laboratory Specialist, Armed Forces Hospital In The Southern Region
Zyad Alrubaie
laboratory Specialist, Armed Forces Hospital
Ahmed Almohammed
laboratory Technician, Armed Forces Hospital In The Southern Region
Saad Mohammad
specialist Laboratory, Armed Forces Hospital In The Southern Region
Abdullah Alqarni
laboratory Specialist, Armed Forces Hospital In The Southern Region
Mohammed Hassan Alqassem
medical Laboratory Specialists, Medical Student In Fourth Year