Association between Vitamin D3 and Glutathione levels in COVID 19 individual

Main Article Content

Khalid Hassan Abdalruda

Keywords

COVID-19 ,Oxidative stress ,Reduced glutathione(GSH) and Vitamin D3

Abstract

Background: COVID-19 is an infectious disease associated with high rate of infected and death specially for older male when they have low levels of glutathione (GSH)  and vitamin D (vit D). The GSH status positively associated with bioavailability of vit D. The GSH deficiency correlated by increased oxidative stress and inflammatory markers which implicate in increase the severity of disease.


Objective: To verify the vitamin D - GSH levels interaction among healthy and COVID- 19 patient.


Method :Control healthy group (166) individual and (171)  COVID 19  patient  were involved in this study. Oxidative stress and antioxidant parameters, Vit D, and inflammatory marker were estimated in both group.


Results: The COVID-19 patient show significant higher level for malondialdehyde (MDA),protein carbonyl group(PC), inturlukin-6 (IL6),Tumor necrosis factor alpha (TNFα) and C-reactive protein (CRP) and significant low level for GSH  and vit D compare to healthy control group, the aged  and male COVID-19 group display significant higher level for MDA,PC and significant low level for GSH compare with younger  and women group.


Conclusion: The COVID-19 patient correlated with higher oxidative stress , inflammatory marker and low level of antioxidant GSH and Vit D which develops by age advancing and especially within  male  .

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