DEVELOPMENT OF SR METFORMIN HCL TABLET USING FLAX AND CHIA SEED MUCILAGE
Main Article Content
Keywords
Chia seeds, Flex seeds, Metfomin HCl, MCC, Magnesium stearate, in-vitro studies
Abstract
Aim: This work is to Development of SR Metformin HCl tablet using flax and chia seed mucilage.
Methods: This present study was to design of SR Metformin HCl tablets using flax and chia seed mucilage. The mucilage was extracted from flax and chia seeds via hot extraction method. Metformin HCl tablets were prepared using mucilage by wet granulation method and then optimized SR action by in vitro studies.
Results: The formulated tablets were evaluated for physical characteristics like weights variations, hardness, friability, drug content and drug release that fulfilled all the official requirements of tablet dosage form. The release rate of SR tablets were carried out in HCl (pH1.2) followed by phosphate buffer (pH 6.8). In-vitro release study shows that the mucilage based SR formulations (TS9) exhibited the highest correlation value (r2) for Higuchi kinetic model.
Conclusion: In vitro studies indicated that the formulation showed better sustained release action.
References
2. Genuth S, Alberti KG, Bennett P, Buse J, Defronzo R., Kahn R., Kitzmiller J, Knowler WC, Lebovitz H, Lernmark A, Nathan D, Palmer J, Rizza R., Saudek C, Shaw J, Steffes M., Stern M., Tuomilehto J, Zimmet P. Expert Committee on the Diagnosis and Classification of Diabetes Mellitus2, the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care. 2003;26: 3160–3167
3. International Expert Committee. International Expert Committee report on the role of the A1C assay in the diagnosis of diabetes. Diabetes Care 2009; 32:1327– 1334
4. Weiss RF, Fintelmann V. Herbal Medicine. 2nd English edition. New York: Thieme, 2000.
5. Akerele O. Summary of WHO guidelines for the assessment of herbal medicines. Herbal Gram 1993; 28: 13-19.
6. Alves MMM. A reologia. In: De Castro AG, editor. A química e a reologia no processamento de alimentos. Lisboa: Instituto Piaget; 2003.
7. Muñoz LA, et al. Chia seeds: microstructure, mucilage extraction and hydration. J Food Eng. 2012;108:216–224. doi: 10.1016/j.jfoodeng.2011.06.037.
8. USP29-NF24. 2017; 28 (2)
9. Lachmman L, Liberman HA, Konig JL. The Theory and practice of industrial pharmacy. Vargheese publishing house, Bombay.1991; 297-301.
10. Otsuka M, Gao J, Matsuda Y. Effect of Amount of Added Water During Extrusion-Spheronization Process on Pharmaceutical Properties of Granules. Drug Development and Industrial Pharmacy.1994; 2977-2992.
11. De Leersnyder F, Vanhoorne V, Bekaert H, Vercruysse J, Ghijs M, Bostijn N, De Beer T. Breakage and drying behaviour of granules in a continuous fluid bed dryer: Influence of process parameters and wet granule transfer. European Journal of Pharmaceutical Sciences. 2018; 223-232.
12. Kumar A, Singh K, Ahuja M. Xanthan-g-poly (acrylamide): Microwave-assisted synthesis, characterization and in vitro release behavior. Carbohydrate Polymers.2009; 76: 261-267.
13. Mandal S, Kumar Basu S, Biswanath Sa. Ca2+ ion cross-linked interpenetrating network matrix tablets of polyacrylamide-grafted-sodium alginate and sodium alginate for sustained release of diltiazem hydrochloride. Carbohydrate Polymers. 2010; 867-873.
14. Bhagwat Durgacharan A, Kolekar Vandana A, Nadaf Sameer J, Choudhari Prafulla B, More Harinath N, Killedar Suresh G. Acrylamide grafted neem (Azadirachta indica) gum polymer: Screening and exploration as a drug release retardant for tablet formulation. Carbohydrate Polymers. 2020; 229
Article Sidebar
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Dr. Asha Gandhi
Sri Sukhmani Institute of Pharmacy, Derabassi
Himani Dhiman
Swami Vivekanand college of Pharmacy, Banur, Patiala
Amanjeet Singh
Sri Sukhmani Institute of Pharmacy, Derabassi
Krishma Kumari
Swami Devi Dyal Institute of Pharmacy, Barwala, Haryana
Deepshikha
Swami Devi Dyal Institute of Pharmacy, Barwala, Haryana