TITANIUM INCORPORATED HYDROXYAPATITE TOWARDS TOOTH REGENERATION
Main Article Content
Keywords
Titanium, hydroxyapatite, tooth regeneration
Abstract
Aim: To incorporate Titanium and hydroxyapatite towards tooth regeneration
Materials and method: Hydroxyapatite was synthesized by co-precipitation method using calcium nitrate and diammonium hydrogen phosphate in the ratio of 1.67.
Then TiO2 nanoparticles dispersed using a bath sonicator, further introducing this into hydroxyapatite precipitates.Then wash the obtained nanoparticles using DD H2O and ethanol followed by the drying in a hot air oven at 120 °C for 12 h.
Results: According to ASTM standard upto 5% lysis is acceptable, in this case we observed below 0.8 % lysis at the concentration of 10mg/mL. It showed a more compatible nature of the material.
Conclusion: Elongated rod-like morphology showed the structure of TiO2 and small rods as well as globule-like structures connected with the TiO2 rods. Further, Ca, P, O, Ti, and C elements were confirmed from EDS spectra.
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2. Mucalo M. Hydroxyapatite (HAp) for Biomedical Applications. Elsevier; 2015. 404 p.
3. Wang G, Lu Z, Zhao X, Kondyurin A, Zreiqat H. Ordered HAp nanoarchitecture formed on HAp-TCP bioceramics by “nanocarving” and mineralization deposition and its potential use for guiding cell behaviors. J Mater Chem B Mater Biol Med. 2013 May 21;1(19):2455–62.
4. Kumar A, Gori Y, Kumar A, Meena CS, Dutt N. Advanced Materials for Biomedical Applications. CRC Press; 2022. 293 p.
5. Luckey HA. Titanium Alloys in Surgical Implants. ASTM International; 1983. 294 p.
6. Li Y, Shui X, Zhang L, Hu J. Cancellous bone healing around strontium-doped hydroxyapatite in osteoporotic rats previously treated with zoledronic acid [Internet]. Vol. 104, Journal of Biomedical Materials Research Part B: Applied Biomaterials. 2016. p. 476–81. Available from: http://dx.doi.org/10.1002/jbm.b.33417
7. Fu XK, Cao HB, An YL, Zhou HD, Shi YP, Hou GL, et al. Bioinspired Hydroxyapatite Coating Infiltrated with a Graphene Oxide Hybrid Supramolecular Hydrogel Orchestrates Antibacterial and Self-Lubricating Performance. ACS Appl Mater Interfaces. 2022 Jul 20;14(28):31702–14.
8. Jokstad A. Osseointegration and Dental Implants. John Wiley & Sons; 2009. 448 p.
9. Janus M. Application of Titanium Dioxide. BoD – Books on Demand; 2017. 242 p.
10. Parrino F, Palmisano L. Titanium Dioxide (TiO2) and Its Applications. Elsevier; 2020. 730 p.
11. Khurana V, Kwatra D, Shah S, Mandal A, Mitra AK. Emerging Nanotechnology for Stem Cell Therapy [Internet]. Emerging Nanotechnologies for Diagnostics, Drug Delivery and Medical Devices. 2017. p. 85–103. Available from: http://dx.doi.org/10.1016/b978-0-323-42978-8.00005-x
12. Rues S, Schmitter M, Kappel S, Sonntag R, Kretzer JP, Nadorf J. Effect of bone quality and quantity on the primary stability of dental implants in a simulated bicortical placement. Clin Oral Investig. 2021 Mar;25(3):1265–72.
13. Boskey AL, Maresca M, Ullrich W, Doty SB, Butler WT, Prince CW. Osteopontin-hydroxyapatite interactions in vitro: inhibition of hydroxyapatite formation and growth in a gelatin-gel [Internet]. Vol. 22, Bone and Mineral. 1993. p. 147–59. Available from: http://dx.doi.org/10.1016/s0169-6009(08)80225-5
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Mohamed Rifaath
Department of ProsthodonticsSaveetha Dental College and HospitalsSaveetha Institute of Medical and Technical SciencesSaveetha University, Chennai-600 077, India
Dr. Marina francis
Department of ProsthodonticsSaveetha Dental College and HospitalsSaveetha Institute of Medical and Technical SciencesSaveetha University, Chennai-600 077, India
